deferoxamine has been researched along with Sensitivity and Specificity in 33 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Sensitivity and Specificity: Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Two studies were conducted to assess the efficacy of the complexes of desferrioxamine with zinc or gallium to prevent this aspect of reperfusion injury." | 3.71 | The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection. ( Berenshtein, E; Chevion, M; Haverich, A; Karck, M; Sturm, C; Tanaka, S, 2001) |
| "Current thalassemia major treatment includes blood transfusion and iron chelation, which is associated with growth disturbances and radiographic changes in the long bone metaphyses." | 2.78 | Deferoxamine-induced dysplasia-like skeletal abnormalities at radiography and MRI. ( Esmail, RI; Lotfy, HM; Magdy, RE; Seif El Dien, HM, 2013) |
| "Thirteen patients with type 1 diabetes underwent PET using nitrogen-13 ammonia at rest and during sympathetic stimulation with the cold pressor test (CPT)." | 2.70 | Deferoxamine improves coronary vascular responses to sympathetic stimulation in patients with type 1 diabetes mellitus. ( Bengel, FM; Drzezga, AE; Hattori, N; Nekolla, SG; Rihl, J; Schnell, O; Schwaiger, M; Standl, E, 2002) |
| "Aiming at a safe method in the diagnosis of aluminium-related bone disease (ARBD)/aluminium overload the low-dose desferrioxamine (DFO) test was developed." | 2.68 | Use of the low-dose desferrioxamine test to diagnose and differentiate between patients with aluminium-related bone disease, increased risk for aluminium toxicity, or aluminium overload. ( Barsoum, RS; Couttenye, MM; D'Haese, PC; De Broe, ME; Digenis, P; Fagalde, A; Goodman, WG; Lamberts, LV; Lemoniatou, E; Sotornik, I, 1995) |
| " Fifty-three patients ingested a median toxic dose of elemental iron of 40." | 1.51 | Minimum ingested iron cut-off triggering serious iron toxicity in children. ( Halil, H; Karacan, CD; Polat, E; Tuygun, N, 2019) |
| "Deferoxamine treatment decreased intracellular iron, suppressed nuclear factor-κB activation, and induced apoptosis." | 1.51 | The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety. ( Buchman, SR; Cohen, MS; Donneys, A; Lynn, JV; Nelson, NS; Ranganathan, K; Subramanian, C; Urlaub, KM, 2019) |
| "Our findings suggest that DFO administration may be safe and useful for ameliorating cisplatin-induced nephrotoxicity." | 1.31 | Experimental study on effects of deferoxamine mesilate in ameliorating cisplatin-induced nephrotoxicity. ( Dokucu, AI; Ece, A; Ozdemir, E; Oztürk, H; Uzunlar, AK; Yaldiz, M, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (33.33) | 18.2507 |
| 2000's | 13 (39.39) | 29.6817 |
| 2010's | 9 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Halil, H | 1 |
| Tuygun, N | 1 |
| Polat, E | 1 |
| Karacan, CD | 1 |
| Lynn, JV | 1 |
| Urlaub, KM | 1 |
| Ranganathan, K | 1 |
| Donneys, A | 2 |
| Nelson, NS | 2 |
| Subramanian, C | 1 |
| Cohen, MS | 1 |
| Buchman, SR | 2 |
| Seif El Dien, HM | 1 |
| Esmail, RI | 1 |
| Magdy, RE | 1 |
| Lotfy, HM | 1 |
| Qiu, D | 1 |
| Chan, GC | 2 |
| Chu, J | 1 |
| Chan, Q | 1 |
| Ha, SY | 2 |
| Moseley, ME | 1 |
| Khong, PL | 2 |
| Page, EE | 1 |
| Deshpande, SS | 1 |
| Felice, PA | 1 |
| Tchanque-Fossuo, CN | 1 |
| Spiegel, JP | 1 |
| Houghton, JL | 1 |
| Zeglis, BM | 1 |
| Abdel-Atti, D | 1 |
| Aggeler, R | 1 |
| Sawada, R | 1 |
| Agnew, BJ | 1 |
| Scholz, WW | 1 |
| Lewis, JS | 1 |
| Su, BL | 1 |
| Moniotte, N | 1 |
| Nivarlet, N | 1 |
| Chen, LH | 1 |
| Fu, ZY | 1 |
| Desmet, J | 1 |
| Li, J | 1 |
| Brown, GC | 1 |
| Patton, WN | 1 |
| Tapp, HE | 1 |
| Taylor, DJ | 1 |
| St Pierre, TG | 1 |
| Shervedani, RK | 1 |
| Akrami, Z | 1 |
| Hattori, N | 1 |
| Schnell, O | 1 |
| Bengel, FM | 1 |
| Rihl, J | 1 |
| Nekolla, SG | 1 |
| Drzezga, AE | 1 |
| Standl, E | 1 |
| Schwaiger, M | 1 |
| Zhang, Q | 1 |
| Huang, X | 1 |
| Hoffband, AV | 1 |
| Monsen, T | 1 |
| Olofsson, C | 1 |
| Granström, S | 1 |
| Wiström, J | 1 |
| Ooi, GC | 1 |
| Chan, KN | 1 |
| Chan, KL | 1 |
| Lam, W | 1 |
| Ng, I | 1 |
| Al-Ghamdi, SS | 1 |
| Chatterjee, PK | 1 |
| Raftery, MJ | 1 |
| Thiemermann, C | 1 |
| Yaqoob, MM | 1 |
| Christoforidis, A | 1 |
| Haritandi, A | 1 |
| Tsatra, I | 1 |
| Tsitourides, I | 1 |
| Karyda, S | 1 |
| Athanassiou-Metaxa, M | 1 |
| Antunes, AL | 1 |
| Secchi, C | 1 |
| Reiter, KC | 1 |
| Perez, LR | 1 |
| de Freitas, AL | 1 |
| D'Azevedo, PA | 1 |
| Matthews, RS | 1 |
| Moeslinger, T | 1 |
| Brunner, M | 1 |
| Spieckermann, PG | 1 |
| Hou, JW | 1 |
| Wu, MH | 1 |
| Lin, KH | 1 |
| Lue, HC | 1 |
| Lindsay, JA | 1 |
| Aravena-Román, MA | 1 |
| Riley, TV | 1 |
| D'Haese, PC | 1 |
| Couttenye, MM | 1 |
| Goodman, WG | 1 |
| Lemoniatou, E | 1 |
| Digenis, P | 1 |
| Sotornik, I | 1 |
| Fagalde, A | 1 |
| Barsoum, RS | 1 |
| Lamberts, LV | 1 |
| De Broe, ME | 1 |
| He, P | 1 |
| Zeng, M | 1 |
| Curry, FE | 1 |
| Vyoral, D | 1 |
| Petrák, J | 1 |
| Hradilek, A | 1 |
| Callaway, JK | 1 |
| Beart, PM | 1 |
| Jarrott, B | 1 |
| Powars, DR | 1 |
| Wong, WY | 1 |
| Vachon, LA | 1 |
| Karck, M | 1 |
| Tanaka, S | 1 |
| Berenshtein, E | 1 |
| Sturm, C | 1 |
| Haverich, A | 1 |
| Chevion, M | 1 |
| Chan, YL | 1 |
| Chu, CW | 1 |
| Chik, KW | 1 |
| Pang, LM | 1 |
| Shing, MK | 1 |
| Li, CK | 1 |
| Rose, C | 1 |
| Cambier, N | 1 |
| Mahieu, M | 1 |
| Ernst, O | 1 |
| Fenaux, P | 1 |
| Ozdemir, E | 1 |
| Dokucu, AI | 1 |
| Uzunlar, AK | 1 |
| Ece, A | 1 |
| Yaldiz, M | 1 |
| Oztürk, H | 1 |
| DeVita, MV | 1 |
| Rasenas, LL | 1 |
| Bansal, M | 1 |
| Gleim, GW | 1 |
| Zabetakis, PM | 1 |
| Gardenswartz, MH | 1 |
| Michelis, MF | 1 |
| Uehara, K | 1 |
| Hori, K | 1 |
| Nakano, M | 1 |
| Koga, S | 1 |
| Boswell, TC | 1 |
| Wilcox, MH | 1 |
| Spencer, RC | 1 |
1 review available for deferoxamine and Sensitivity and Specificity
| Article | Year |
|---|---|
[Iron overload and myelodysplastic syndromes].
Topics: Administration, Oral; Aged; Biopsy; Chelation Therapy; Deferiprone; Deferoxamine; Erythrocyte Transf | 2001 |
4 trials available for deferoxamine and Sensitivity and Specificity
| Article | Year |
|---|---|
Deferoxamine-induced dysplasia-like skeletal abnormalities at radiography and MRI.
Topics: Adolescent; Adult; beta-Thalassemia; Bone Diseases, Developmental; Chelating Agents; Child; Child, P | 2013 |
Deferoxamine improves coronary vascular responses to sympathetic stimulation in patients with type 1 diabetes mellitus.
Topics: Ammonia; Cold Temperature; Coronary Circulation; Coronary Vessels; Deferoxamine; Diabetes Mellitus, | 2002 |
Four-year evaluation of myocardial and liver iron assessed prospectively with serial MRI scans in young patients with beta-thalassaemia major: comparison between different chelation regimens.
Topics: Adolescent; Adult; beta-Thalassemia; Chelation Therapy; Child; Deferiprone; Deferoxamine; Drug Thera | 2007 |
Use of the low-dose desferrioxamine test to diagnose and differentiate between patients with aluminium-related bone disease, increased risk for aluminium toxicity, or aluminium overload.
Topics: Adult; Aged; Aluminum; Bone Diseases; Deferoxamine; Dose-Response Relationship, Drug; Female; Humans | 1995 |
28 other studies available for deferoxamine and Sensitivity and Specificity
| Article | Year |
|---|---|
Minimum ingested iron cut-off triggering serious iron toxicity in children.
Topics: Adolescent; Child; Deferoxamine; Eating; Female; Humans; Iron; Male; Poisoning; Retrospective Studie | 2019 |
The Role of Deferoxamine in Irradiated Breast Reconstruction: A Study of Oncologic Safety.
Topics: Analysis of Variance; Apoptosis; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deferoxamine; | 2019 |
MR quantitative susceptibility imaging for the evaluation of iron loading in the brains of patients with β-thalassemia major.
Topics: Adolescent; Adult; beta-Thalassemia; Brain; Chelating Agents; Deferoxamine; Female; Humans; Iron; Ir | 2014 |
Targeting angiogenesis as a therapeutic means to reinforce osteocyte survival and prevent nonunions in the aftermath of radiotherapy.
Topics: Analysis of Variance; Animals; Biopsy, Needle; Cell Survival; Cells, Cultured; Deferoxamine; Disease | 2015 |
Site-specifically labeled CA19.9-targeted immunoconjugates for the PET, NIRF, and multimodal PET/NIRF imaging of pancreatic cancer.
Topics: Animals; Antibodies, Monoclonal; CA-19-9 Antigen; Cell Line, Tumor; Deferoxamine; Disease Models, An | 2015 |
Fl-DFO molecules@mesoporous silica materials: highly sensitive and selective nanosensor for dosing with iron ions.
Topics: Deferoxamine; Fluorescein; Iron; Models, Molecular; Nanostructures; Porosity; Sensitivity and Specif | 2011 |
Spin density projection-assisted R2 magnetic resonance imaging of the liver in the management of body iron stores in patients receiving multiple red blood cell transfusions: an audit and retrospective study in South Australia.
Topics: Adolescent; Adult; Aged; Benzoates; Chelation Therapy; Child; Deferasirox; Deferoxamine; Erythrocyte | 2012 |
Gold-deferrioxamine nanometric interface for selective recognition of Fe(III) using square wave voltammetry and electrochemical impedance spectroscopy methods.
Topics: Biosensing Techniques; Deferoxamine; Dielectric Spectroscopy; Electrochemical Techniques; Ferric Com | 2013 |
Induction of ferritin and lipid peroxidation by coal samples with different prevalence of coal workers' pneumoconiosis: role of iron in the coals.
Topics: Cells, Cultured; Coal; Coal Mining; Deferoxamine; Dust; Ferritins; Humans; Lipid Peroxidation; Lung; | 2002 |
A sensitive test for early myocardial iron loading.
Topics: beta-Thalassemia; Cardiomyopathies; Deferoxamine; Humans; Iron Chelating Agents; Iron Overload; Magn | 2003 |
A preliminary evaluation of a new selective agar supplemented with desferrioxamine for detection of methicillin-resistant Staphylococcus aureus.
Topics: Agar; Culture Media; Deferoxamine; Iron Chelating Agents; Methicillin Resistance; Microbiological Te | 2003 |
Magnetic resonance screening of iron status in transfusion-dependent beta-thalassaemia patients.
Topics: Adolescent; Adult; beta-Thalassemia; Case-Control Studies; Deferoxamine; Female; Ferritins; Humans; | 2004 |
Role of cytochrome P4502E1 activation in proximal tubular cell injury induced by hydrogen peroxide.
Topics: Allyl Compounds; Animals; Apoptosis; Cells, Cultured; Cytochrome P-450 CYP2E1; Cytochrome P-450 CYP2 | 2004 |
Feasible identification of Staphylococcus epidermidis using desferrioxamine and fosfomycin disks.
Topics: Bacterial Typing Techniques; Coagulase; Deferoxamine; Feasibility Studies; Fosfomycin; Humans; Sensi | 2008 |
Artemia salina as a test organism for measuring superoxide-mediated toxicity.
Topics: Animals; Artemia; Biological Assay; Deferoxamine; Dimethyl Sulfoxide; Drug Evaluation, Preclinical; | 1995 |
Spectrophotometric determination of dehydroascorbic acid in biological samples.
Topics: 3T3 Cells; Animals; Ascorbic Acid; Chromatography, High Pressure Liquid; Deferoxamine; Dehydroascorb | 1994 |
Prognostic significance of left ventricular diastolic indexes in beta-thalassemia major.
Topics: Adolescent; Adult; Age Factors; beta-Thalassemia; Child; Child, Preschool; Deferoxamine; Diastole; E | 1994 |
Identification of Staphylococcus epidermidis and Staphylococcus hominis from blood cultures by testing susceptibility to desferrioxamine.
Topics: Bacteremia; Coagulase; Deferoxamine; Evaluation Studies as Topic; Humans; Microbial Sensitivity Test | 1993 |
Effect of nitric oxide synthase inhibitors on basal microvessel permeability and endothelial cell [Ca2+]i.
Topics: Animals; Calcium; Capillary Permeability; Deferoxamine; Endothelium, Vascular; Enzyme Inhibitors; Ex | 1997 |
Separation of cellular iron containing compounds by electrophoresis.
Topics: Animals; Autoradiography; Deferoxamine; Electrophoresis, Polyacrylamide Gel; Iron; Iron Chelating Ag | 1998 |
A reliable procedure for comparison of antioxidants in rat brain homogenates.
Topics: Animals; Antioxidants; Brain; Brain Chemistry; Chromans; Deferoxamine; Ferric Compounds; Inhibitory | 1998 |
Incomplete cerebral infarctions are not silent.
Topics: Adolescent; Anemia, Sickle Cell; Blood Flow Velocity; Bone Marrow Transplantation; Brain Damage, Chr | 2001 |
The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection.
Topics: Analysis of Variance; Animals; Cardioplegic Solutions; Deferoxamine; Disease Models, Animal; Drug Sy | 2001 |
Deferoxamine-induced dysplasia of the knee: sonographic features and diagnostic performance compared with magnetic resonance imaging.
Topics: Adolescent; beta-Thalassemia; Blood Transfusion; Bone Diseases, Developmental; Chelating Agents; Chi | 2001 |
Experimental study on effects of deferoxamine mesilate in ameliorating cisplatin-induced nephrotoxicity.
Topics: Animals; Biopsy, Needle; Cisplatin; Deferoxamine; Disease Models, Animal; Dose-Response Relationship | 2002 |
Assessment of renal osteodystrophy in hemodialysis patients.
Topics: Absorptiometry, Photon; Alkaline Phosphatase; Aluminum; Biopsy; Calcium; Chronic Kidney Disease-Mine | 1992 |
Highly sensitive chemiluminescence method for determining myeloperoxidase in human polymorphonuclear leukocytes.
Topics: Deferoxamine; Free Radicals; Humans; Hydrogen Peroxide; Imidazoles; Neutrophils; Oxygen; Peroxidase; | 1991 |
Susceptibility of coagulase-negative staphylococci to desferrioxamine.
Topics: Deferoxamine; Diagnosis, Differential; Humans; Sensitivity and Specificity; Staphylococcal Infection | 1991 |