deferoxamine has been researched along with Retinal Degeneration in 8 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Retinal Degeneration: A retrogressive pathological change in the retina, focal or generalized, caused by genetic defects, inflammation, trauma, vascular disease, or aging. Degeneration affecting predominantly the macula lutea of the retina is MACULAR DEGENERATION. (Newell, Ophthalmology: Principles and Concepts, 7th ed, p304)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Deferoxamine retinopathy is the informally designated term used to describe a characteristic pattern of outer retinal degeneration in iron-overloaded chronic anemia patients who are treated with deferoxamine." | 5.12 | Iron overload and iron chelating agent exposure in anemia-associated outer retinal degeneration: a case report and review of the literature. ( Belmouhand, M; Eckmann-Hansen, C; Ilginis, T; Larsen, M; Leinøe, EB; Mortensen, BK, 2021) |
| "We report two cases of bilateral macular pattern dystrophy in transfusion dependent patients undergoing chronic chelation therapy with deferoxamine due to thalassemias." | 3.88 | Pattern dystrophies in patients treated with deferoxamine: report of two cases and review of the literature. ( Georgakopoulos, CD; Kostopoulou, EV; Makri, OE; Tsapardoni, F, 2018) |
| "Eight patients (16 eyes) developed ocular toxicity while undergoing intravenous deferoxamine mesylate (Desferal) chelation therapy for transfusional hemosiderosis." | 3.67 | Deferoxamine (Desferal)-induced toxic retinal pigmentary degeneration and presumed optic neuropathy. ( Jiji, R; Lakhanpal, V; Schocket, SS, 1984) |
| "Deferoxamine toxicity was immediately suspected and therapy promptly interrupted." | 1.40 | Spectral domain optical coherence tomography findings in early deferoxamine maculopathy: report of two cases. ( Alami, A; Benghiat, FS; Rasquin, F; Van Bol, L, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (25.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (25.00) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Belmouhand, M | 1 |
| Eckmann-Hansen, C | 1 |
| Ilginis, T | 1 |
| Leinøe, EB | 1 |
| Mortensen, BK | 1 |
| Larsen, M | 1 |
| Georgakopoulos, CD | 1 |
| Tsapardoni, F | 1 |
| Kostopoulou, EV | 1 |
| Makri, OE | 1 |
| Van Bol, L | 1 |
| Alami, A | 1 |
| Benghiat, FS | 1 |
| Rasquin, F | 1 |
| Lakhanpal, V | 1 |
| Schocket, SS | 1 |
| Jiji, R | 1 |
| Mehta, AM | 1 |
| Engstrom, RE | 1 |
| Kreiger, AE | 1 |
| Michon, JJ | 1 |
| Li, ZL | 2 |
| Shioura, N | 1 |
| Anderson, RJ | 1 |
| Tso, MO | 2 |
| Lam, S | 1 |
| Rahi, AH | 1 |
| Hungerford, JL | 1 |
| Ahmed, AI | 1 |
1 review available for deferoxamine and Retinal Degeneration
| Article | Year |
|---|---|
Iron overload and iron chelating agent exposure in anemia-associated outer retinal degeneration: a case report and review of the literature.
Topics: beta-Thalassemia; Deferoxamine; Humans; Iron Chelating Agents; Iron Overload; Retinal Degeneration; | 2021 |
7 other studies available for deferoxamine and Retinal Degeneration
| Article | Year |
|---|---|
Pattern dystrophies in patients treated with deferoxamine: report of two cases and review of the literature.
Topics: Deferoxamine; Electroretinography; Female; Humans; Infusions, Subcutaneous; Middle Aged; Retina; Ret | 2018 |
Spectral domain optical coherence tomography findings in early deferoxamine maculopathy: report of two cases.
Topics: Deferoxamine; Female; Humans; Leukemia, Monocytic, Acute; Middle Aged; Retinal Degeneration; Siderop | 2014 |
Deferoxamine (Desferal)-induced toxic retinal pigmentary degeneration and presumed optic neuropathy.
Topics: Aged; Blood Transfusion; Color Perception; Deferoxamine; Female; Hemosiderosis; Humans; Male; Middle | 1984 |
Deferoxamine-associated retinopathy after subcutaneous injection.
Topics: Aged; Anemia, Refractory; Color Vision Defects; Deferoxamine; Female; Fluorescein Angiography; Fundu | 1994 |
A comparative study of methods of photoreceptor morphometry.
Topics: Animals; Cell Count; Deferoxamine; Image Processing, Computer-Assisted; Light; Models, Biological; P | 1991 |
Desferrioxamine ameliorates retinal photic injury in albino rats.
Topics: Animals; Cell Count; Deferoxamine; Light; Macrophages; Photoreceptor Cells; Pigment Epithelium of Ey | 1991 |
Ocular toxicity of desferrioxamine: light microscopic histochemical and ultrastructural findings.
Topics: Adult; Choroid; Ciliary Body; Deferoxamine; Humans; Iron Chelating Agents; Male; Microscopy, Electro | 1986 |