deferoxamine has been researched along with Reperfusion Injury in 109 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Reperfusion Injury: Adverse functional, metabolic, or structural changes in tissues that result from the restoration of blood flow to the tissue (REPERFUSION) following ISCHEMIA.
| Excerpt | Relevance | Reference |
|---|---|---|
| " This study examined the role of deferoxamine (DFX) in brain injury and HT in a rat model of transient focal ischemia with hyperglycemia." | 7.75 | Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia. ( Hua, Y; Keep, RF; Xi, G; Xing, Y, 2009) |
| "This study investigated whether hepatocyte Ca2+ dysregulation after hemorrhagic shock and resuscitation could be modulated by the iron chelator hydroxyethyl starch-conjugated deferoxamine (HES-DFO)." | 7.70 | Starch-deferoxamine conjugate inhibits hepatocyte Ca2+ uptake during hemorrhagic shock and resuscitation. ( Pizanis, A; Rose, S; Silomon, M, 2000) |
| "The dose effect of deferoxamine treatment in attenuation of ischemia-induced reperfusion injury in the skin and muscle of latissimus dorsi myocutaneous flaps was studied in pigs weighing 19." | 7.68 | Deferoxamine attenuates ischemia-induced reperfusion injury in the skin and muscle of myocutaneous flaps in the pig. ( Boyd, B; Davidson, G; Lindsay, WK; Lofchy, NM; Morris, SF; Pang, CY; Zuker, RM, 1993) |
| "Treatment with deferoxamine (iron chelator) did not affect WRN." | 5.39 | N-acetylcysteine ameliorates acute kidney injury but not glomerular hemorrhage in an animal model of warfarin-related nephropathy. ( Brodsky, SV; Hebert, LA; Nadasdy, G; Nadasdy, T; Ozcan, A; Qamri, Z; Rovin, BH; Satoskar, AA; Ware, K, 2013) |
| "Deferoxamine (DFO) is a high-affinity iron chelator approved by the Food and Drug Administration for treating iron overload." | 5.35 | Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. ( Coppes, VG; Frey, WH; Hanson, LR; Hoekman, JD; Marti, DL; Martinez, PM; Matthews, RB; Panter, SS; Rao, RJ; Roeytenberg, A; Sweet, DC, 2009) |
| "Pretreatment with gadolinium chloride, an inhibitor of Kupffer cell function, significantly decreased LDH and PNP efflux during reperfusion by approximately 60% and 50%, respectively." | 5.31 | Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers. ( Bailey, SM; Reinke, LA, 2000) |
| "Experimental studies suggest that deferoxamine (DFO) limits the generation of reactive oxygen species by chelating redox-active iron and thereby may reduce ischemia-reperfusion injury and myocardial infarct (MI) size." | 5.16 | Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction. ( Chan, W; Croft, KD; Dart, AM; Duffy, SJ; Ellims, AH; Kaye, DM; Kingwell, BA; Lefkovits, L; Mori, T; Natoli, A; Taylor, AJ; Wong, C, 2012) |
| "Deferoxamine mesylate is known to ameliorate tissue ischemia-reperfusion injury." | 3.77 | Protective effects of deferoxamine mesylate preconditioning on pancreatic tissue in orthotopic liver autotransplantation in rats. ( Feng, M; Jin, C; Li, Y; Liu, XY; Tao, LD; Zhang, PJ; Zhou, B, 2011) |
| " This study examined the role of deferoxamine (DFX) in brain injury and HT in a rat model of transient focal ischemia with hyperglycemia." | 3.75 | Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia. ( Hua, Y; Keep, RF; Xi, G; Xing, Y, 2009) |
| " Two studies were conducted to assess the efficacy of the complexes of desferrioxamine with zinc or gallium to prevent this aspect of reperfusion injury." | 3.71 | The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection. ( Berenshtein, E; Chevion, M; Haverich, A; Karck, M; Sturm, C; Tanaka, S, 2001) |
| "This study investigated whether hepatocyte Ca2+ dysregulation after hemorrhagic shock and resuscitation could be modulated by the iron chelator hydroxyethyl starch-conjugated deferoxamine (HES-DFO)." | 3.70 | Starch-deferoxamine conjugate inhibits hepatocyte Ca2+ uptake during hemorrhagic shock and resuscitation. ( Pizanis, A; Rose, S; Silomon, M, 2000) |
| "A previous study indicated that hydroxyl radicals are generated in the cat retina during the early reperfusion phase after 90 minutes of ischemia." | 3.69 | Protection of the transiently ischemic cat retina by zinc-desferrioxamine. ( Averbukh, E; Berenshtein, E; Kitrossky, N; Ophir, A, 1994) |
| " To evaluate whether iron chelation with deferoxamine interrupts this process in postischemic skeletal muscle, high-grade partial hindlimb ischemia was created in Sprague-Dawley rats by clamping the infrarenal aorta for 90 min, after which period the clamp was removed and flow was reestablished for 60 min." | 3.68 | Deferoxamine prevents lipid peroxidation and attenuates reoxygenation injury in postischemic skeletal muscle. ( Fantini, GA; Yoshioka, T, 1993) |
| "The dose effect of deferoxamine treatment in attenuation of ischemia-induced reperfusion injury in the skin and muscle of latissimus dorsi myocutaneous flaps was studied in pigs weighing 19." | 3.68 | Deferoxamine attenuates ischemia-induced reperfusion injury in the skin and muscle of myocutaneous flaps in the pig. ( Boyd, B; Davidson, G; Lindsay, WK; Lofchy, NM; Morris, SF; Pang, CY; Zuker, RM, 1993) |
| "The beneficial effect of desferrioxamine and dimethylthiourea suggest that it is intensification of the Fenton reaction by iron which accounts for iron induced aggravation of the reperfusion injury." | 3.68 | Iron availability and free radical induced injury in the isolated ischaemic/reperfused rat heart. ( Beresewicz, A; Czarnowska, E; Karwatowska-Prokopczuk, E, 1992) |
| "Deferoxamine was given both intravenously (30 mg/kg body wt, starting 30 minutes before bypass and extending for the next 4 hours) and as an additive to the cardioplegic solution (250 mg/l)." | 2.67 | Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans. ( Alcindor, LG; Antebi, H; Giudicelli, Y; Menasché, P; Nordmann, R; Perez, G; Piwnica, A; Teiger, E, 1990) |
| "Treatment with deferoxamine (iron chelator) did not affect WRN." | 1.39 | N-acetylcysteine ameliorates acute kidney injury but not glomerular hemorrhage in an animal model of warfarin-related nephropathy. ( Brodsky, SV; Hebert, LA; Nadasdy, G; Nadasdy, T; Ozcan, A; Qamri, Z; Rovin, BH; Satoskar, AA; Ware, K, 2013) |
| "Ischemia/reperfusion injury is a leading cause of acute renal failure triggering an inflammatory response associated with infiltrating macrophages, which determine disease outcome." | 1.38 | Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2. ( Hotter, G; Hughes, J; Jung, M; Kluth, DC; Pérez-Ladaga, A; Sola, A; Viñas, JL; Vinuesa, E, 2012) |
| "Spinal cord ischemia was induced in Sprague-Dawley rats by infrarenal aortic occlusion for 30 min followed by 72 h of reperfusion." | 1.37 | Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats. ( Jiang, DM; Liang, Y; Yang, QH; Yu, XD, 2011) |
| "Deferoxamine-treated animals had reduced total bilirubin, gamma-glutamyl transferase and ammonia levels as well as hepatocyte necrosis and oxidative injury." | 1.36 | Iron chelation for amelioration of liver ischemia-reperfusion injury. ( Arkadopoulos, N; Economou, E; Kalimeris, K; Kostopanagiotou, G; Kouskouni, E; Nastos, C; Pafiti, A; Smyrniotis, V; Theodoraki, K, 2010) |
| "Deferoxamine-treated control myocytes responded similarly." | 1.35 | Hypoxia inducible factor-1 improves the actions of positive inotropic agents in stunned cardiac myocytes. ( Luciano, JA; Scholz, PM; Tan, T; Weiss, HR, 2009) |
| "Deferoxamine (DFO) is a high-affinity iron chelator approved by the Food and Drug Administration for treating iron overload." | 1.35 | Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. ( Coppes, VG; Frey, WH; Hanson, LR; Hoekman, JD; Marti, DL; Martinez, PM; Matthews, RB; Panter, SS; Rao, RJ; Roeytenberg, A; Sweet, DC, 2009) |
| "Deferoxamine treated control myocytes responded similarly." | 1.35 | Hypoxia inducible factor-1 improves the actions of nitric oxide and natriuretic peptides after simulated ischemia-reperfusion. ( Huang, E; Luciano, JA; Scholz, P; Tan, T; Weiss, HR; Zhang, Q, 2008) |
| "Pretreatment with gadolinium chloride, an inhibitor of Kupffer cell function, significantly decreased LDH and PNP efflux during reperfusion by approximately 60% and 50%, respectively." | 1.31 | Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers. ( Bailey, SM; Reinke, LA, 2000) |
| "Preeclampsia is a severe disorder of human pregnancy characterized by generalized activation of maternal endothelial cells." | 1.31 | Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia. ( Burton, GJ; Charnock-Jones, DS; Hung, TH; Skepper, JN, 2002) |
| "Free radical-mediated reperfusion injury has been demonstrated in ischemic neonatal bowel necrosis, but the mechanism of injury remains elusive." | 1.29 | Prevention of postischemic injury in immature intestine by deferoxamine. ( Cobb, LM; Lelli, JL; Pradhan, S, 1993) |
| "Acute testicular torsion is a surgical emergency which requires immediate intervention." | 1.29 | Reperfusion injury following testicular torsion and detorsion in prepubertal rats. ( Blank, ML; Chaudry, IH; Cobb, LM; Havenstein, PJ; O'Neill, PJ; Steigman, CK; Wilde, RA, 1993) |
| "Pretreatment with deferoxamine resulted in a significant decrease in lung leak as compared to animals pretreated with vehicle prior to I/R (DES-I/R = 0." | 1.29 | Desferal attenuates TNF release following hepatic ischemia/reperfusion. ( Campbell, DA; Colletti, LM; Remick, DG, 1994) |
| "Reperfusion injury is a phenomenon complicating microvascular reconstruction." | 1.29 | Limiting impairment of muscle function following ischemia and reperfusion in rabbits. ( Huang, L; Klitzman, B; Panza, W; Serafin, D; Zavitsanos, G, 1996) |
| "Treatment with gadolinium chloride (GdCl3) selectively reduced the capacity of Kupffer cells to generate superoxide by 65% and attenuated liver injury by 73% at 4 h and 58-69% at 24 h." | 1.29 | Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia. ( Farhood, A; Fisher, MA; Jaeschke, H; Liu, P; McGuire, GM; Smith, CW, 1995) |
| " These findings were correlated with the dosage of vitamin E since the vitamin E content was greatly reduced by 46." | 1.29 | Preservation of cortical microcirculation after kidney ischemia-reperfusion: value of an iron chelator. ( Defraigne, JO; Detry, O; Franssen, C; Limet, R; Meurisse, M; Pincemail, J, 1994) |
| "In dogs, gastric dilatation-volvulus (GDV) is characterized by cardiogenic shock, with resulting hypoperfusion." | 1.28 | Treatment of reperfusion injury in dogs with experimentally induced gastric dilatation-volvulus. ( Arkin, TE; Badylak, SF; Hiles, MC; Lantz, GC, 1992) |
| "Reperfusion injury was seen in endothelial cells in the form of swelling that was not prevented by HCA or DFX." | 1.28 | Ultrastructural changes and lipid peroxidation in rat adipomusculocutaneous flap isotransplants after normothermic storage and reperfusion. ( Charlett, A; Fryer, PR; Gower, JD; Green, CJ; Manek, S; Nishikawa, H, 1992) |
| "During anoxia, LDH release was substantially reduced at acidotic pH (pH 6." | 1.28 | Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox. ( Currin, RT; Gores, GJ; Lemasters, JJ; Thurman, RG, 1991) |
| "Reperfusion injury is a limiting factor in lung transplantation." | 1.28 | Iron chelation therapy and lung transplantation. Effects of deferoxamine on lung preservation in canine single lung transplantation. ( Conte, JV; Foegh, ML; Katz, NM; Ramwell, PW; Wallace, RB, 1991) |
| "Frostbite is characterized by acute tissue injury induced by freezing and thawing." | 1.28 | Evidence for an early free radical-mediated reperfusion injury in frostbite. ( Bulkley, GB; Im, MJ; Jesudass, R; Manson, PN; Marzella, L; Narayan, KK, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (3.67) | 18.7374 |
| 1990's | 68 (62.39) | 18.2507 |
| 2000's | 22 (20.18) | 29.6817 |
| 2010's | 11 (10.09) | 24.3611 |
| 2020's | 4 (3.67) | 2.80 |
| Authors | Studies |
|---|---|
| Rodrigo, R | 1 |
| Prieto, JC | 1 |
| Aguayo, R | 1 |
| Ramos, C | 1 |
| Puentes, Á | 1 |
| Gajardo, A | 1 |
| Panieri, E | 1 |
| Rojas-Solé, C | 1 |
| Lillo-Moya, J | 1 |
| Saso, L | 1 |
| Yu, X | 1 |
| Ma, X | 1 |
| Lyu, J | 1 |
| Jiang, N | 1 |
| Lu, Y | 1 |
| Liao, Y | 1 |
| Wang, K | 1 |
| Yu, W | 1 |
| Wang, X | 1 |
| Li, M | 1 |
| Diao, K | 1 |
| Wang, Y | 2 |
| Chen, H | 1 |
| Zhao, Z | 1 |
| Li, Y | 2 |
| Jia, X | 1 |
| Wang, H | 1 |
| Zheng, F | 1 |
| Xia, Z | 1 |
| Han, L | 1 |
| Zhang, M | 1 |
| Kim, KM | 1 |
| Cho, SS | 1 |
| Ki, SH | 1 |
| Ware, K | 1 |
| Qamri, Z | 1 |
| Ozcan, A | 1 |
| Satoskar, AA | 1 |
| Nadasdy, G | 1 |
| Rovin, BH | 1 |
| Hebert, LA | 1 |
| Nadasdy, T | 1 |
| Brodsky, SV | 1 |
| Ayvaz, S | 1 |
| Inan, M | 1 |
| Aksu, B | 1 |
| Karaca, T | 1 |
| Cemek, M | 1 |
| Ayaz, A | 1 |
| Basaran, UN | 1 |
| Pul, M | 1 |
| Trogadas, G | 1 |
| Mastoraki, A | 1 |
| Nastos, C | 3 |
| Kondi-Pafiti, A | 1 |
| Kostopanagiotou, G | 4 |
| Smyrniotis, V | 4 |
| Arkadopoulos, N | 4 |
| Tan, T | 2 |
| Luciano, JA | 2 |
| Scholz, PM | 1 |
| Weiss, HR | 2 |
| Hanson, LR | 1 |
| Roeytenberg, A | 1 |
| Martinez, PM | 1 |
| Coppes, VG | 1 |
| Sweet, DC | 1 |
| Rao, RJ | 1 |
| Marti, DL | 1 |
| Hoekman, JD | 1 |
| Matthews, RB | 1 |
| Frey, WH | 1 |
| Panter, SS | 1 |
| Xing, Y | 1 |
| Hua, Y | 1 |
| Keep, RF | 1 |
| Xi, G | 1 |
| Kalimeris, K | 2 |
| Economou, E | 1 |
| Theodoraki, K | 2 |
| Kouskouni, E | 1 |
| Pafiti, A | 2 |
| Liang, Y | 1 |
| Yang, QH | 1 |
| Yu, XD | 1 |
| Jiang, DM | 1 |
| Papoutsidakis, N | 1 |
| Defterevos, G | 1 |
| Kalogeropoulou, H | 1 |
| Zerva, L | 1 |
| Nomikos, T | 1 |
| Santana-Rodríguez, N | 1 |
| Clavo, B | 1 |
| Llontop, P | 1 |
| López, A | 1 |
| García-Castellano, JM | 1 |
| Machín, RP | 1 |
| Ponce, MA | 1 |
| Fiuza, MD | 1 |
| García-Herrera, R | 1 |
| Brito, Y | 1 |
| Yordi, NA | 1 |
| Chirino, R | 1 |
| Kyriazi, MA | 1 |
| Theodosopoulos, T | 1 |
| Thedosopoulos, T | 1 |
| Tsiantoula, P | 1 |
| Fragulidis, G | 1 |
| Zhang, PJ | 1 |
| Jin, C | 1 |
| Zhou, B | 1 |
| Liu, XY | 1 |
| Tao, LD | 1 |
| Feng, M | 1 |
| Jung, M | 1 |
| Sola, A | 1 |
| Hughes, J | 1 |
| Kluth, DC | 1 |
| Vinuesa, E | 1 |
| Viñas, JL | 1 |
| Pérez-Ladaga, A | 1 |
| Hotter, G | 2 |
| Chan, W | 1 |
| Taylor, AJ | 1 |
| Ellims, AH | 1 |
| Lefkovits, L | 1 |
| Wong, C | 1 |
| Kingwell, BA | 1 |
| Natoli, A | 1 |
| Croft, KD | 1 |
| Mori, T | 1 |
| Kaye, DM | 1 |
| Dart, AM | 1 |
| Duffy, SJ | 1 |
| Park, K | 1 |
| Chung, KY | 1 |
| Sung, SH | 1 |
| Kim, BR | 1 |
| Kim, YS | 1 |
| Ohlmann, A | 1 |
| Giffhorn-Katz, S | 1 |
| Becker, I | 1 |
| Katz, N | 1 |
| Immenschuh, S | 1 |
| Liachenko, S | 1 |
| Tang, P | 1 |
| Xu, Y | 1 |
| Peeters-Scholte, C | 1 |
| Braun, K | 1 |
| Koster, J | 1 |
| Kops, N | 1 |
| Blomgren, K | 1 |
| Buonocore, G | 1 |
| van Buul-Offers, S | 1 |
| Hagberg, H | 1 |
| Nicolay, K | 1 |
| van Bel, F | 1 |
| Groenendaal, F | 1 |
| Nigri, GR | 1 |
| Kossodo, S | 1 |
| Waterman, P | 1 |
| Fungaloi, P | 1 |
| LaMuraglia, GM | 1 |
| Polat, C | 1 |
| Tokyol, C | 1 |
| Kahraman, A | 1 |
| Sabuncuoğlu, B | 1 |
| Yìlmaz, S | 1 |
| Zhang, Q | 1 |
| Huang, E | 1 |
| Scholz, P | 1 |
| Haraldsson, G | 1 |
| Sörensen, V | 1 |
| Nilsson, U | 1 |
| Pettersson, S | 1 |
| Rashid, M | 1 |
| Scherstén, T | 1 |
| Akerlund, S | 1 |
| Jonsson, O | 1 |
| Gehlbach, P | 1 |
| Purple, RL | 1 |
| Lepore, DA | 2 |
| Knight, KR | 3 |
| Bhattacharya, S | 1 |
| Ritz, M | 1 |
| Robbins, SP | 1 |
| Sieg, P | 1 |
| Morrison, WA | 2 |
| O'Brien, BM | 2 |
| Gonzalez-Fajardo, JA | 1 |
| Fernandez, L | 1 |
| Alvarez, T | 1 |
| Vaquero, C | 1 |
| Ozaki, M | 1 |
| Fuchinoue, S | 1 |
| Teraoka, S | 1 |
| Ota, K | 1 |
| Reuter, DG | 1 |
| Tacker, WA | 1 |
| Babbs, CF | 2 |
| Badylak, SF | 2 |
| Voorhees, WD | 1 |
| Konrad, PE | 1 |
| Turnage, RH | 1 |
| Magee, JC | 1 |
| Guice, KS | 1 |
| Myers, SI | 1 |
| Oldham, KT | 1 |
| Ress, AM | 1 |
| Babovic, S | 1 |
| Angel, MF | 2 |
| Im, MJ | 3 |
| Dellon, AL | 1 |
| Manson, PN | 2 |
| Defraigne, JO | 3 |
| Pincemail, J | 3 |
| Detry, O | 3 |
| Franssen, C | 3 |
| Meurisse, M | 3 |
| Limet, R | 3 |
| Lamy, M | 1 |
| Drossos, G | 1 |
| Lazou, A | 1 |
| Panagopoulos, P | 1 |
| Westaby, S | 1 |
| Liu, P | 1 |
| McGuire, GM | 1 |
| Fisher, MA | 1 |
| Farhood, A | 1 |
| Smith, CW | 1 |
| Jaeschke, H | 1 |
| Moore, LE | 1 |
| Traystman, RJ | 2 |
| Sorrenti, V | 1 |
| Di Giacomo, C | 1 |
| Renis, M | 1 |
| Russo, A | 1 |
| La Delfa, C | 1 |
| Perez-Polo, JR | 1 |
| Vanella, A | 1 |
| Hershko, C | 1 |
| Colletti, LM | 1 |
| Remick, DG | 1 |
| Campbell, DA | 1 |
| Baron, P | 2 |
| Gugliuzza, K | 1 |
| Rajaraman, S | 1 |
| Thompson, JC | 1 |
| Ophir, A | 1 |
| Berenshtein, E | 3 |
| Kitrossky, N | 2 |
| Averbukh, E | 1 |
| Blank, ML | 1 |
| O'Neill, PJ | 1 |
| Steigman, CK | 1 |
| Cobb, LM | 2 |
| Wilde, RA | 1 |
| Havenstein, PJ | 1 |
| Chaudry, IH | 1 |
| Qayumi, AK | 2 |
| Janusz, MT | 2 |
| Dorovini-Zis, K | 1 |
| Lyster, DM | 2 |
| Jamieson, WR | 2 |
| Poostizadeh, A | 1 |
| Feeley, EJ | 1 |
| Nikbakht-Sangari, M | 1 |
| Werker, PM | 1 |
| Kon, M | 1 |
| Green, CJ | 3 |
| Franken, RJ | 1 |
| Overgoor, ML | 1 |
| Pi, F | 1 |
| Closa, D | 1 |
| Roselló-Catafau, J | 1 |
| Bulbena, O | 1 |
| Badosa, F | 1 |
| Morris, M | 1 |
| Fernández-Cruz, L | 1 |
| Gelpi, E | 1 |
| Fantini, GA | 1 |
| Yoshioka, T | 1 |
| Egri, L | 2 |
| Lelli, JL | 1 |
| Pradhan, S | 1 |
| Morris, SF | 1 |
| Pang, CY | 1 |
| Lofchy, NM | 1 |
| Davidson, G | 1 |
| Lindsay, WK | 1 |
| Zuker, RM | 1 |
| Boyd, B | 1 |
| Smith, GS | 1 |
| Mercer, DW | 1 |
| Cross, JM | 1 |
| Barreto, JC | 1 |
| Miller, TA | 1 |
| Messent, M | 1 |
| Griffiths, MJ | 1 |
| Quinlan, GJ | 1 |
| Gutteridge, JM | 1 |
| Evans, TW | 1 |
| Zavitsanos, G | 1 |
| Huang, L | 1 |
| Panza, W | 1 |
| Serafin, D | 1 |
| Klitzman, B | 1 |
| Shibuya, K | 1 |
| Edagawa, M | 1 |
| Takenaka, H | 1 |
| Matsuzaki, Y | 1 |
| Shibata, KI | 1 |
| Onitsuka, T | 1 |
| Koga, Y | 1 |
| Hamada, M | 1 |
| Colet, JM | 1 |
| Cetiner, E | 1 |
| Hedlund, BE | 3 |
| Muller, RN | 1 |
| Zhao, G | 1 |
| Ayene, IS | 1 |
| Fisher, AB | 1 |
| Bauer, C | 1 |
| Marzi, I | 1 |
| Larsen, R | 1 |
| Rauen, U | 1 |
| Elling, B | 1 |
| de Groot, H | 1 |
| Hickey, MJ | 1 |
| Hurley, JV | 1 |
| Dailly, E | 1 |
| Urien, S | 1 |
| Tillement, JP | 1 |
| Shimmura, S | 1 |
| Shimoyama, M | 1 |
| Hojo, M | 1 |
| Urayama, K | 1 |
| Tsubota, K | 1 |
| Collard, CD | 1 |
| Agah, A | 1 |
| Stahl, GL | 1 |
| Parkins, CS | 1 |
| Holder, AL | 1 |
| Dennis, MF | 1 |
| Stratford, MR | 1 |
| Chaplin, DJ | 1 |
| Marin, PC | 1 |
| Girotto, JA | 1 |
| Borschel, G | 1 |
| Bickel, KD | 1 |
| Vreugdenhil, PK | 1 |
| Ametani, MS | 1 |
| Haworth, RA | 1 |
| Southard, JH | 1 |
| Kumamoto, Y | 1 |
| Suematsu, M | 1 |
| Shimazu, M | 1 |
| Kato, Y | 1 |
| Sano, T | 1 |
| Makino, N | 1 |
| Hirano, KI | 1 |
| Naito, M | 1 |
| Wakabayashi, G | 1 |
| Ishimura, Y | 1 |
| Kitajima, M | 1 |
| Banin, E | 1 |
| Pe'er, J | 1 |
| Chevion, M | 2 |
| Bailey, SM | 1 |
| Reinke, LA | 1 |
| Feng, Y | 1 |
| LeBlanc, MH | 1 |
| LeBlanc, EB | 1 |
| Parker, CC | 1 |
| Fratkin, JD | 1 |
| Qian, XB | 1 |
| Patel, DM | 1 |
| Huang, M | 1 |
| Smith, EE | 1 |
| Vig, PJ | 1 |
| Chatterjee, PK | 1 |
| Cuzzocrea, S | 1 |
| Brown, PA | 1 |
| Zacharowski, K | 1 |
| Stewart, KN | 1 |
| Mota-Filipe, H | 1 |
| Thiemermann, C | 1 |
| Rose, S | 1 |
| Pizanis, A | 1 |
| Silomon, M | 1 |
| Karck, M | 1 |
| Tanaka, S | 1 |
| Sturm, C | 1 |
| Haverich, A | 1 |
| Sandau, KB | 1 |
| Zhou, J | 1 |
| Kietzmann, T | 1 |
| Brüne, B | 1 |
| Tabuchi, K | 2 |
| Okubo, H | 1 |
| Fujihira, K | 1 |
| Tsuji, S | 2 |
| Hara, A | 2 |
| Kusakari, J | 2 |
| Hung, TH | 2 |
| Skepper, JN | 2 |
| Burton, GJ | 2 |
| Asaka, Y | 1 |
| Charnock-Jones, DS | 1 |
| Lantz, GC | 1 |
| Hiles, MC | 1 |
| Arkin, TE | 1 |
| Nishikawa, H | 1 |
| Gower, JD | 1 |
| Fryer, PR | 2 |
| Charlett, A | 1 |
| Manek, S | 1 |
| Andrews, FJ | 1 |
| Malcontenti, C | 1 |
| O'Brien, PE | 1 |
| Karwatowska-Prokopczuk, E | 1 |
| Czarnowska, E | 1 |
| Beresewicz, A | 1 |
| Kirsch, JR | 1 |
| Helfaer, MA | 1 |
| Lange, DG | 1 |
| Corcoran, PC | 1 |
| Katz, NM | 2 |
| Rajan, SS | 1 |
| Analouei, AR | 1 |
| Foegh, ML | 2 |
| Wallace, RB | 2 |
| Turner, JJ | 1 |
| Rice-Evans, CA | 1 |
| Davies, MJ | 1 |
| Newman, ES | 1 |
| Kunz, R | 1 |
| Schoenberg, MH | 1 |
| Büchler, M | 1 |
| Jost, K | 1 |
| Beger, HG | 1 |
| Maruyama, M | 1 |
| Pieper, GM | 1 |
| Kalyanaraman, B | 1 |
| Hallaway, PE | 2 |
| Gross, GJ | 1 |
| Boros, M | 1 |
| Kaszaki, J | 1 |
| Nagy, S | 1 |
| Suzuki, M | 1 |
| Grisham, MB | 1 |
| Granger, DN | 1 |
| Purucker, E | 1 |
| Hamar, H | 1 |
| Augustin, AJ | 1 |
| Lutz, J | 2 |
| Currin, RT | 1 |
| Gores, GJ | 1 |
| Thurman, RG | 1 |
| Lemasters, JJ | 1 |
| Conte, JV | 1 |
| Ramwell, PW | 1 |
| Jesudass, R | 1 |
| Marzella, L | 1 |
| Bulkley, GB | 2 |
| Narayan, KK | 1 |
| Gomez-Marin, O | 1 |
| Casas, C | 1 |
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| Condie, R | 1 |
| Burke, B | 1 |
| Najarian, JS | 1 |
| Sutherland, DE | 1 |
| Augustin, A | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery: Proposal for Pilot Investigation[NCT02519335] | Phase 1 | 12 participants (Actual) | Interventional | 2014-09-30 | Terminated (stopped due to PI no longer at this facility) | ||
| Use of the Cardioprotectant Dexrazoxane During Congenital Heart Surgery[NCT04997291] | Phase 1 | 12 participants (Anticipated) | Interventional | 2021-04-09 | Recruiting | ||
| Double-blind, Randomized, Placebo Controlled, Dose-finding Phase 2 Clinical Trial of Intravenous Deferoxamine in Patients With Acute Ischemic Stroke Treated With Tissue Plasminogen Activator[NCT00777140] | Phase 2 | 62 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
6 reviews available for deferoxamine and Reperfusion Injury
| Article | Year |
|---|---|
Joint Cardioprotective Effect of Vitamin C and Other Antioxidants against Reperfusion Injury in Patients with Acute Myocardial Infarction Undergoing Percutaneous Coronary Intervention.
Topics: Acetylcysteine; Animals; Antioxidants; Ascorbic Acid; Biomarkers; Deferoxamine; Dose-Response Relati | 2021 |
Emerging roles of ferroptosis in liver pathophysiology.
Topics: Animals; Antineoplastic Agents; Caffeic Acids; Carcinoma, Hepatocellular; Cycloheximide; Cyclohexyla | 2020 |
Role of oxygen free radicals and lipid peroxidation in cerebral reperfusion injury.
Topics: Animals; Cerebrovascular Circulation; Deferoxamine; Free Radicals; Humans; Lipid Peroxidation; Neuro | 1994 |
Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators.
Topics: Animals; Brain; Cell Division; Chelation Therapy; Deferoxamine; Graft Rejection; Heart; Humans; Iron | 1994 |
Evidence for free radical mechanisms of brain injury resulting from ischemia/reperfusion-induced events.
Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Deferoxamine; Free Radical Scavengers; Free Radicals | 1992 |
Role of iron and oxygen radicals in hemorrhage and shock.
Topics: Animals; Deferoxamine; Free Radicals; Hemorrhage; Humans; Iron; Oxygen; Reperfusion Injury; Shock | 1991 |
3 trials available for deferoxamine and Reperfusion Injury
| Article | Year |
|---|---|
Effect of iron chelation on myocardial infarct size and oxidative stress in ST-elevation-myocardial infarction.
Topics: Aged; Angioplasty; Chelating Agents; Coronary Vessels; Deferoxamine; Echocardiography; Electrocardio | 2012 |
Deferoxamine cardioplegia reduces superoxide radical production in human myocardium.
Topics: Aged; Bicarbonates; Calcium Chloride; Cardiac Surgical Procedures; Cardioplegic Solutions; Deferoxam | 1995 |
Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans.
Topics: Cardiopulmonary Bypass; Deferoxamine; Female; Free Radicals; Humans; Iron; Lipid Peroxidation; Lipop | 1990 |
Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans.
Topics: Cardiopulmonary Bypass; Deferoxamine; Female; Free Radicals; Humans; Iron; Lipid Peroxidation; Lipop | 1990 |
Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans.
Topics: Cardiopulmonary Bypass; Deferoxamine; Female; Free Radicals; Humans; Iron; Lipid Peroxidation; Lipop | 1990 |
Iron chelation by deferoxamine inhibits lipid peroxidation during cardiopulmonary bypass in humans.
Topics: Cardiopulmonary Bypass; Deferoxamine; Female; Free Radicals; Humans; Iron; Lipid Peroxidation; Lipop | 1990 |
100 other studies available for deferoxamine and Reperfusion Injury
| Article | Year |
|---|---|
Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation.
Topics: Animals; Brain Injuries; Child; Deferoxamine; Ferroptosis; Humans; Iron; Ischemia; Liver; Liver Tran | 2022 |
Deferoxamine attenuates visual impairment in retinal ischemia‒reperfusion via inhibiting ferroptosis.
Topics: Animals; Deferoxamine; Ferritins; Ferroptosis; Glutathione; Humans; Rats; Reactive Oxygen Species; R | 2023 |
N-acetylcysteine ameliorates acute kidney injury but not glomerular hemorrhage in an animal model of warfarin-related nephropathy.
Topics: Acetylcysteine; Acute Kidney Injury; Animals; Creatinine; Deferoxamine; Erythrocytes; Male; Nephrect | 2013 |
Desferrioxamine effectively attenuates testicular tissue at the end of 3 h of ischemia but not in an equal period of reperfusion.
Topics: Animals; Deferoxamine; Disease Models, Animal; Follow-Up Studies; Male; Rats; Rats, Sprague-Dawley; | 2014 |
Comparative Effects of Ischemic Preconditioning and Iron Chelation in Hepatectomy.
Topics: Animals; Deferoxamine; Female; Hepatectomy; Iron Chelating Agents; Ischemic Preconditioning; Liver D | 2015 |
Hypoxia inducible factor-1 improves the actions of positive inotropic agents in stunned cardiac myocytes.
Topics: Animals; Antifungal Agents; Calcium Signaling; Cardiotonic Agents; Ciclopirox; Colforsin; Deferoxami | 2009 |
Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Brain; Brain Ischemia; Deferoxamine; Dose-Res | 2009 |
Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Chemistry; Brain Edema; Deferoxamine; Hemoglo | 2009 |
Iron chelation for amelioration of liver ischemia-reperfusion injury.
Topics: Adult; Aged; Aged, 80 and over; Animals; Deferoxamine; Disease Models, Animal; Female; Humans; Iron | 2010 |
Additive effect of tetramethylpyrazine and deferoxamine in the treatment of spinal cord injury caused by aortic cross-clamping in rats.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aorta, Abdominal; Deferoxamine; Disease Models, An | 2011 |
Antioxidant treatment attenuates intestinal mucosal damage and gut barrier dysfunction after major hepatectomy. Study in a porcine model.
Topics: Animals; Antioxidants; Deferoxamine; Disease Models, Animal; Dose-Response Relationship, Drug; Femal | 2011 |
Estradiol worsens the syndrome of ischemia-reperfusion injury in an experimental lung transplantation model.
Topics: Animals; Antioxidants; Chi-Square Distribution; Deferoxamine; Disease Models, Animal; Estradiol; Gra | 2011 |
Evaluation of ischemia-reperfusion liver injury by near-infrared spectroscopy in an experimental swine model: the effect of desferoxamine.
Topics: Animals; Antioxidants; Apoptosis; Biopsy; Caspase 3; Deferoxamine; Female; Hepatectomy; Infusions, I | 2011 |
Protective effects of deferoxamine mesylate preconditioning on pancreatic tissue in orthotopic liver autotransplantation in rats.
Topics: Amylases; Animals; Deferoxamine; Hypoxia-Inducible Factor 1, alpha Subunit; Immunohistochemistry; Li | 2011 |
Infusion of IL-10-expressing cells protects against renal ischemia through induction of lipocalin-2.
Topics: Acute Kidney Injury; Adoptive Transfer; Animals; Blood Urea Nitrogen; Cell Survival; Deferoxamine; D | 2012 |
Protective effect of desferrioxamine during canine liver transplantation: significance of peritransplant liver biopsy.
Topics: Animals; Biopsy; Deferoxamine; Dogs; Female; Iron Chelating Agents; Liver; Liver Function Tests; Liv | 2003 |
Regulation of heme oxygenase-1 gene expression by anoxia and reoxygenation in primary rat hepatocyte cultures.
Topics: Allopurinol; Animals; Antioxidants; beta Carotene; Cell Hypoxia; Cells, Cultured; Cycloheximide; Dac | 2003 |
Deferoxamine improves early postresuscitation reperfusion after prolonged cardiac arrest in rats.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Deferoxamine; Heart Arrest; He | 2003 |
Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia.
Topics: Allopurinol; Animals; Animals, Newborn; Brain; Caspase 3; Caspases; Deferoxamine; Enzyme Inhibitors; | 2003 |
Free radical attenuation prevents thrombosis and enables photochemical inhibition of vein graft intimal hyperplasia.
Topics: Animals; Antibodies, Monoclonal; Blood Vessel Prosthesis; Blood Vessel Prosthesis Implantation; Cell | 2004 |
The effects of desferrioxamine and quercetin on hepatic ischemia-reperfusion induced renal disturbance.
Topics: Animals; Blood Urea Nitrogen; Creatinine; Deferoxamine; Glutathione; Kidney; Liver; Male; Malondiald | 2006 |
Hypoxia inducible factor-1 improves the actions of nitric oxide and natriuretic peptides after simulated ischemia-reperfusion.
Topics: Animals; Cyclic GMP-Dependent Protein Kinases; Deferoxamine; Hypoxia-Inducible Factor 1, alpha Subun | 2008 |
Effect of pre-treatment with desferrioxamine and mannitol on radical production and kidney function after ischaemia-reperfusion. A study on rabbit kidneys.
Topics: Animals; Deferoxamine; Free Radicals; Kidney; Kidney Glomerulus; Kidney Tubules; Mannitol; Rabbits; | 1995 |
Enhancement of retinal recovery by conjugated deferoxamine after ischemia-reperfusion.
Topics: Animals; Blood-Retinal Barrier; Cats; Deferoxamine; Disease Models, Animal; Electroretinography; Flu | 1994 |
Drug mixture which improves survival of ischemic rabbit epigastric skin flaps.
Topics: Adenosine Triphosphate; Animals; Deferoxamine; Dextrans; Drug Combinations; Epoprostenol; Heparin; I | 1994 |
Preservation of cortical microcirculation after kidney ischemia-reperfusion: value of an iron chelator.
Topics: Animals; Deferoxamine; Ischemia; Kidney Cortex; Microcirculation; Rabbits; Renal Circulation; Reperf | 1995 |
The in vivo cytoprotection of ascorbic acid against ischemia/reoxygenation injury of rat liver.
Topics: Adenosine Triphosphate; Alanine Transaminase; Animals; Ascorbic Acid; Aspartate Aminotransferases; D | 1995 |
Preliminary results of deferoxamine and L1 treatment of spinal cord ischemia.
Topics: Animals; Deferiprone; Deferoxamine; Dogs; Iron Chelating Agents; Ischemia; Pyridones; Reperfusion In | 1995 |
Complement activation by the hydroxyl radical during intestinal reperfusion.
Topics: Animals; Chemotactic Factors; Complement Activation; Complement C5a; Deferoxamine; Disease Models, A | 1994 |
Free radical damage in acute nerve compression.
Topics: Animals; Antioxidants; Deferoxamine; Diabetes Mellitus, Experimental; Diabetic Neuropathies; Female; | 1995 |
Preservation of cortical microcirculation after kidney ischemia-reperfusion: value of an iron chelator.
Topics: Animals; Constriction; Deferoxamine; Ischemia; Kidney Cortex; Laser-Doppler Flowmetry; Microcirculat | 1994 |
Direct evidence of free radical production after ischaemia and reperfusion and protective effect of desferrioxamine: ESR and vitamin E studies.
Topics: Animals; Deferoxamine; Dose-Response Relationship, Drug; Electron Spin Resonance Spectroscopy; Free | 1994 |
Activation of Kupffer cells and neutrophils for reactive oxygen formation is responsible for endotoxin-enhanced liver injury after hepatic ischemia.
Topics: Animals; Antibodies, Monoclonal; CD11 Antigens; Chromans; Deferoxamine; Gadolinium; Ischemia; Kupffe | 1995 |
Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: effect of drugs with different molecular mechanisms.
Topics: Allopurinol; Animals; Antioxidants; Brain Ischemia; Deferoxamine; Diltiazem; Lipid Peroxidation; Mal | 1994 |
Desferal attenuates TNF release following hepatic ischemia/reperfusion.
Topics: Alanine Transaminase; Animals; Deferoxamine; Disease Models, Animal; Liver; Liver Diseases; Lung Dis | 1994 |
Ceruloplasmin and deferoxamine prevent ischemia-reperfusion damage in kidney transplantation.
Topics: Animals; Ceruloplasmin; Deferoxamine; Dogs; Kidney Transplantation; Organ Preservation; Reperfusion | 1994 |
Protection of the transiently ischemic cat retina by zinc-desferrioxamine.
Topics: Animals; Cats; Deferoxamine; Electroretinography; Fundus Oculi; Hydroxybenzoates; Hydroxyl Radical; | 1994 |
Reperfusion injury following testicular torsion and detorsion in prepubertal rats.
Topics: Animals; Deferoxamine; Diltiazem; Male; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sodium Chlor | 1993 |
Additive effect of allopurinol and deferoxamine in the prevention of spinal cord injury caused by aortic crossclamping.
Topics: Allopurinol; Animals; Aorta, Thoracic; Constriction; Deferoxamine; Drug Therapy, Combination; Female | 1994 |
Neither desferrioxamine nor lipoic acid enhances the cold ischaemic tolerance of epigastric free flaps in rats.
Topics: Adipose Tissue; Animals; Citrates; Cold Temperature; Deferoxamine; Free Radicals; Graft Survival; Hy | 1993 |
Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation.
Topics: Animals; Deferoxamine; Diterpenes; Eicosanoids; Ginkgolides; Lactones; Male; Pancreas Transplantatio | 1994 |
Deferoxamine prevents lipid peroxidation and attenuates reoxygenation injury in postischemic skeletal muscle.
Topics: Animals; Deferoxamine; Electrophysiology; Hindlimb; Ischemia; Lipid Peroxides; Male; Muscles; Rats; | 1993 |
[Examination of the reperfusion damage to a striated muscle: possible pathomechanism and prevention].
Topics: Animals; Catalase; Deferoxamine; Drug Evaluation, Preclinical; Ischemia; Methylprednisolone; Muscles | 1993 |
Prevention of postischemic injury in immature intestine by deferoxamine.
Topics: Animals; Constriction; Deferoxamine; Intestines; Ischemia; Male; Mesenteric Arteries; Rats; Rats, Sp | 1993 |
Deferoxamine attenuates ischemia-induced reperfusion injury in the skin and muscle of myocutaneous flaps in the pig.
Topics: Animals; Biopsy; Deferoxamine; Male; Microscopy, Electron; Muscles; Reperfusion Injury; Skin; Surgic | 1993 |
Gastric injury induced by ethanol and ischemia-reperfusion in the rat. Differing roles for lipid peroxidation and oxygen radicals.
Topics: Allopurinol; Animals; Antioxidants; Catalase; Deferoxamine; Dimethyl Sulfoxide; Ethanol; Free Radica | 1996 |
Ischaemia--reperfusion injury in the rat is modulated by superoxide generation and leads to an augmentation of the hypoxic pulmonary vascular response.
Topics: Animals; Arginine; Catalase; Deferoxamine; Ischemia; Linolenic Acids; Lung; Male; NG-Nitroarginine M | 1996 |
Limiting impairment of muscle function following ischemia and reperfusion in rabbits.
Topics: Animals; Calcium Channel Blockers; Deferoxamine; Dimethyl Sulfoxide; Forelimb; Free Radical Scavenge | 1996 |
Protection of isolated lung from reperfusion injuries by rinsing with high colloidal osmotic solution with deferoaxmine.
Topics: Animals; Blood Pressure; Colloids; Deferoxamine; Hypothermia, Induced; Lipid Peroxides; Lung; Male; | 1996 |
Assessment of microvascular integrity in the isolated perfused rat liver by contrast-enhanced MRI. Attenuation of reperfusion injury by conjugated deferoxamine.
Topics: Alanine Transaminase; Animals; Chelating Agents; Deferoxamine; Hydroxyethyl Starch Derivatives; Imag | 1996 |
Role of iron in ischemia-reperfusion oxidative injury of rat lungs.
Topics: Animals; Deferoxamine; Ferric Compounds; Ferrous Compounds; Hydroxyquinolines; In Vitro Techniques; | 1997 |
[Deferoxamine-conjugated hydroxyethyl starch reduces reperfusion injury to the liver following hemorrhagic shock].
Topics: Animals; Antioxidants; Blood Volume; Cell Adhesion; Chelating Agents; Deferoxamine; Female; Glutathi | 1997 |
Injury to cultured liver endothelial cells after cold preservation: mediation by reactive oxygen species that are released independently of the known trigger hypoxia/reoxygenation.
Topics: Animals; Cell Hypoxia; Cell Line; Cell Size; Cell Survival; Cryopreservation; Cyclic N-Oxides; Defer | 1997 |
Influence of postischemic administration of oxyradical antagonists on ischemic injury to rabbit skeletal muscle.
Topics: Allopurinol; Animals; Catalase; Deferoxamine; Enzyme Inhibitors; Female; Free Radical Scavengers; Ma | 1996 |
Chain-breaking antioxidants and ferriheme-bound drugs are synergistic inhibitors of erythrocyte membrane peroxidation.
Topics: Adult; Amidines; Antioxidants; Ascorbic Acid; Chloroquine; Deferoxamine; Drug Synergism; Erythrocyte | 1998 |
Reoxygenation injury in a cultured corneal epithelial cell line protected by the uptake of lactoferrin.
Topics: Blotting, Western; Cell Hypoxia; Cell Line; Cell Survival; Cells, Cultured; Coloring Agents; Deferox | 1998 |
Complement activation following reoxygenation of hypoxic human endothelial cells: role of intracellular reactive oxygen species, NF-kappaB and new protein synthesis.
Topics: Cell Hypoxia; Cells, Cultured; Complement Activation; Complement C3b; Deferoxamine; Dose-Response Re | 1998 |
Involvement of oxygen free radicals in ischaemia-reperfusion injury to murine tumours: role of nitric oxide.
Topics: Adenocarcinoma; Animals; Catalase; Deferoxamine; Endothelium, Vascular; Female; Free Radical Scaveng | 1998 |
Effects of hydroxyethyl-starch-bound deferoxamine on ischemia/reperfusion injury in chronic nerve compression.
Topics: Animals; Deferoxamine; Hydroxyethyl Starch Derivatives; Iron Chelating Agents; Male; Malondialdehyde | 1998 |
Biphasic mechanism for hypothermic induced loss of protein synthesis in hepatocytes.
Topics: Adenosine; Allopurinol; Animals; Antioxidants; Chromans; Cryopreservation; Cytosol; Deferoxamine; Di | 1999 |
Kupffer cell-independent acute hepatocellular oxidative stress and decreased bile formation in post-cold-ischemic rat liver.
Topics: Animals; Antioxidants; Ascorbic Acid; Bile; Clodronic Acid; Cold Temperature; Deferoxamine; Fluoresc | 1999 |
Gallium-desferrioxamine protects the cat retina against injury after ischemia and reperfusion.
Topics: Adenine Nucleotides; Animals; Cats; Deferoxamine; Electroretinography; Energy Metabolism; Guanine Nu | 2000 |
Ischemia-reperfusion injury of rabbit kidney: comparative effects of desferrioxamine and N-acetylcysteine as antioxidants.
Topics: Acetylcysteine; Animals; Antioxidants; Aspartate Aminotransferases; Deferoxamine; Glutathione; Ische | 2000 |
Antioxidants and gadolinium chloride attenuate hepatic parenchymal and endothelial cell injury induced by low flow ischemia and reperfusion in perfused rat livers.
Topics: Animals; Antioxidants; Blood Flow Velocity; Catalase; Deferoxamine; Endothelium, Vascular; Gadoliniu | 2000 |
Desmethyl tirilazad improves neurologic function after hypoxic ischemic brain injury in piglets.
Topics: Animals; Animals, Newborn; Antioxidants; Asphyxia Neonatorum; Brain; Deferoxamine; Dose-Response Rel | 2000 |
Tempol, a membrane-permeable radical scavenger, reduces oxidant stress-mediated renal dysfunction and injury in the rat.
Topics: Acute Kidney Injury; Animals; Cell Membrane Permeability; Cell Separation; Cells, Cultured; Chelatin | 2000 |
Starch-deferoxamine conjugate inhibits hepatocyte Ca2+ uptake during hemorrhagic shock and resuscitation.
Topics: Animals; Calcium; Deferoxamine; Disease Models, Animal; Hemodynamics; Hydroxyethyl Starch Derivative | 2000 |
The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection.
Topics: Analysis of Variance; Animals; Cardioplegic Solutions; Deferoxamine; Disease Models, Animal; Drug Sy | 2001 |
Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide.
Topics: Androstadienes; Arsenicals; Deferoxamine; Genistein; Hypoxia-Inducible Factor 1, alpha Subunit; Infl | 2001 |
Protection of outer hair cells from reperfusion injury by an iron chelator and a nitric oxide synthase inhibitor in the guinea pig cochlea.
Topics: Animals; Deferoxamine; Enzyme Inhibitors; Free Radicals; Guinea Pigs; Hair Cells, Auditory, Outer; H | 2001 |
In vitro ischemia-reperfusion injury in term human placenta as a model for oxidative stress in pathological pregnancies.
Topics: Aldehydes; Cyclic N-Oxides; Deferoxamine; Female; Fluorescent Antibody Technique; Heat-Shock Protein | 2001 |
Ischemia-reperfusion injury of the cochlea: effects of an iron chelator and nitric oxide synthase inhibitors.
Topics: Action Potentials; Animals; Auditory Threshold; Blood Flow Velocity; Blood Pressure; Cochlea; Defero | 2001 |
Hypoxia-reoxygenation: a potent inducer of apoptotic changes in the human placenta and possible etiological factor in preeclampsia.
Topics: Apoptosis; Caspase 3; Caspases; Cell Hypoxia; Cell Nucleus; Chorionic Villi; Culture Techniques; Cyt | 2002 |
Treatment of reperfusion injury in dogs with experimentally induced gastric dilatation-volvulus.
Topics: Animals; Deferoxamine; Dimethyl Sulfoxide; Disease Models, Animal; Dog Diseases; Dogs; Gastric Dilat | 1992 |
Ultrastructural changes and lipid peroxidation in rat adipomusculocutaneous flap isotransplants after normothermic storage and reperfusion.
Topics: Adipose Tissue; Animals; Citrates; Deferoxamine; Hypertonic Solutions; Lipid Peroxidation; Microscop | 1992 |
Pharmacologic interventions for prevention of spinal cord injury caused by aortic crossclamping.
Topics: Allopurinol; Animals; Aorta; Aortic Aneurysm; Constriction; Deferoxamine; Free Radicals; Paraplegia; | 1992 |
Sequence of gastric mucosal injury following ischemia and reperfusion. Role of reactive oxygen metabolites.
Topics: Allopurinol; Animals; Catalase; Deferoxamine; Free Radicals; Gastric Mucosa; Ischemia; Male; Oxygen; | 1992 |
Iron availability and free radical induced injury in the isolated ischaemic/reperfused rat heart.
Topics: Allopurinol; Animals; Biological Availability; Deferoxamine; Ferric Compounds; Ferrous Compounds; Fr | 1992 |
Platelet activating factor antagonist enhances lung preservation in a canine model of single lung allotransplantation.
Topics: Adenosine; Allopurinol; Animals; Deferoxamine; Diterpenes; Dogs; Ginkgolides; Glutathione; Insulin; | 1992 |
The formation of free radicals by cardiac myocytes under oxidative stress and the effects of electron-donating drugs.
Topics: Acetylcysteine; Animals; Deferoxamine; Electron Spin Resonance Spectroscopy; Free Radicals; In Vitro | 1991 |
Oxygen radicals in liver ischemia and reperfusion--experimental data.
Topics: Allopurinol; Animals; Deferoxamine; Electron Spin Resonance Spectroscopy; Fatty Acids, Nonesterified | 1991 |
Effects of hydroxyethyl starch conjugated deferoxamine on myocardial functional recovery following coronary occlusion and reperfusion in dogs.
Topics: Animals; Coronary Circulation; Deferoxamine; Deoxyribose; Dogs; Dose-Response Relationship, Drug; El | 1991 |
Histamine release during intestinal ischemia-reperfusion: role of iron ions and hydrogen peroxide.
Topics: Animals; Deferoxamine; Dogs; Female; Histamine; Histamine Release; Hydrogen Peroxide; Intestinal Muc | 1991 |
Leukocyte-endothelial cell adhesive interactions: role of xanthine oxidase-derived oxidants.
Topics: Animals; Catalase; Cats; Cell Adhesion; Cell Communication; Deferoxamine; Dose-Response Relationship | 1991 |
Differences in glutathione status and lipid peroxidation of red and white muscles: alterations following ischemia and reperfusion.
Topics: Animals; Catalase; Deferoxamine; Glutathione; Glutathione Disulfide; Lipid Peroxidation; Male; Methy | 1991 |
Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox.
Topics: Animals; Antioxidants; Cell Survival; Deferoxamine; Hydrogen-Ion Concentration; Hypoxia; L-Lactate D | 1991 |
Iron chelation therapy and lung transplantation. Effects of deferoxamine on lung preservation in canine single lung transplantation.
Topics: Animals; Deferoxamine; Dogs; Lung; Lung Compliance; Lung Transplantation; Organ Preservation; Oxygen | 1991 |
Evidence for an early free radical-mediated reperfusion injury in frostbite.
Topics: Allopurinol; Animals; Deferoxamine; Disease Models, Animal; Ear; Free Radicals; Freezing; Frostbite; | 1991 |
Renal preservation after warm ischemia using oxygen free radical scavengers to prevent reperfusion injury.
Topics: Animals; Ceruloplasmin; Creatinine; Deferoxamine; Dogs; Free Radical Scavengers; Hot Temperature; Is | 1991 |
Severity of oxygen free radical effects after ischemia and reperfusion in intestinal tissue and the influence of different drugs.
Topics: Allopurinol; Animals; Catalase; Deferoxamine; Free Radicals; Hemoglobins; Intestinal Mucosa; Intesti | 1990 |
Ultrastructural changes in rat lungs after 48 h cold storage with and without reperfusion.
Topics: Allopurinol; Animals; Basement Membrane; Cryopreservation; Deferoxamine; Endothelium, Vascular; Epop | 1990 |
The effects of an iron chelator on cellular injury induced by vascular stasis caused by hypothermia.
Topics: Animals; Creatine Kinase; Deferoxamine; Hindlimb; Hydroxides; Hydroxyl Radical; Hypothermia, Induced | 1990 |
Iron depletion or chelation reduces ischemia/reperfusion-induced edema in gerbil brains.
Topics: Animals; Brain; Brain Chemistry; Brain Edema; Brain Ischemia; Deferoxamine; Female; Gerbillinae; Hem | 1990 |
Intracellular iron redistribution. An important determinant of reperfusion damage to rabbit kidneys.
Topics: Animals; Cold Temperature; Deferoxamine; Ferric Compounds; Iron; Kidney; Kidney Transplantation; Lip | 1990 |
Inhibition of the compartment syndrome by the ablation of free radical-mediated reperfusion injury.
Topics: Allopurinol; Animals; Blood Pressure; Compartment Syndromes; Deferoxamine; Free Radicals; Ischemia; | 1990 |
The reduction of radiation damage to the spinal cord by post-irradiation administration of vasoactive drugs.
Topics: Animals; Deferoxamine; Dipyridamole; Male; Necrosis; Radiation Injuries, Experimental; Rats; Reperfu | 1990 |
Prevention of postischaemic lipid peroxidation and liver cell injury by iron chelation.
Topics: Animals; Deferoxamine; Ischemia; Lipid Peroxidation; Liver; Male; Rats; Rats, Inbred Strains; Reperf | 1989 |
The effect of deferoxamine on tolerance to secondary ischaemia caused by venous obstruction.
Topics: Animals; Deferoxamine; Graft Occlusion, Vascular; Male; Rats; Rats, Inbred Strains; Reperfusion Inju | 1989 |
Comparative analysis of pharmacological agents following small bowel ischemia.
Topics: Acute Disease; Allopurinol; Animals; Deferoxamine; Drug Combinations; Free Radicals; Intestinal Dise | 1988 |
The post treatment experiment: an operational definition of reperfusion injury.
Topics: Allopurinol; Animals; Creatine Kinase; Deferoxamine; Disease Models, Animal; Heart Arrest; Ischemia; | 1988 |