deferoxamine has been researched along with Pulmonary Fibrosis in 11 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Pulmonary Fibrosis: A process in which normal lung tissues are progressively replaced by FIBROBLASTS and COLLAGEN causing an irreversible loss of the ability to transfer oxygen into the bloodstream via PULMONARY ALVEOLI. Patients show progressive DYSPNEA finally resulting in death.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Eight patients with transfusion-dependent thalassemia major were given continuous intravenous infusions of the chelator, deferoxamine mesylate, to reduce iron overload." | 7.68 | Pulmonary syndrome in patients with thalassemia major receiving intravenous deferoxamine infusions. ( Freedman, MH; Grisaru, D; MacLusky, I; Olivieri, N; Thorner, PS, 1990) |
| "Eight patients with transfusion-dependent thalassemia major were given continuous intravenous infusions of the chelator, deferoxamine mesylate, to reduce iron overload." | 3.68 | Pulmonary syndrome in patients with thalassemia major receiving intravenous deferoxamine infusions. ( Freedman, MH; Grisaru, D; MacLusky, I; Olivieri, N; Thorner, PS, 1990) |
| "However, its role in pulmonary fibrosis, a fatal lung disease with unknown etiology, is largely unknown." | 1.62 | Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis. ( Cheng, H; Feng, D; Gao, L; Li, C; Li, X; Liu, W; Luo, Z; Tang, S; Wu, X; Yue, S, 2021) |
| "Deferoxamine pretreatment and daily injections resulted in a significant reduction in lung collagen content and lung lipid peroxidation 21 days after intratracheal bleomycin compared with bleomycin treatment alone." | 1.27 | Modulation of the development of bleomycin-induced fibrosis by deferoxamine. ( Barton, JC; Briggs, DD; Butler, TW; Chandler, DB; Fulmer, JD; Grizzle, WE, 1988) |
| "Deferoxamine pretreatment and daily injection for 21 days after intratracheally administered bleomycin resulted in a 33% reduction in lung collagen accumulation compared with that after bleomycin treatment alone." | 1.27 | The effect of deferoxamine on bleomycin-induced lung fibrosis in the hamster. ( Chandler, DB; Fulmer, JD, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (54.55) | 18.7374 |
| 1990's | 3 (27.27) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Cheng, H | 1 |
| Feng, D | 1 |
| Li, X | 1 |
| Gao, L | 1 |
| Tang, S | 1 |
| Liu, W | 1 |
| Wu, X | 1 |
| Yue, S | 1 |
| Li, C | 1 |
| Luo, Z | 1 |
| Jack, CI | 1 |
| Jackson, MJ | 1 |
| Johnston, ID | 1 |
| Hind, CR | 1 |
| Kim, KA | 1 |
| Park, CY | 1 |
| Lim, Y | 1 |
| Lee, KH | 1 |
| Castriota Scanderbeg, A | 1 |
| Izzi, GC | 1 |
| Butturini, A | 1 |
| Benaglia, G | 1 |
| Freedman, MH | 2 |
| Grisaru, D | 1 |
| Olivieri, N | 1 |
| MacLusky, I | 1 |
| Thorner, PS | 1 |
| Cross, CE | 1 |
| Warren, D | 1 |
| Gerriets, JE | 1 |
| Wilson, DW | 1 |
| Halliwell, B | 1 |
| Last, JA | 1 |
| Kennedy, JI | 1 |
| Chandler, DB | 3 |
| Jackson, RM | 1 |
| Fulmer, JD | 3 |
| Butler, TW | 1 |
| Briggs, DD | 1 |
| Grizzle, WE | 1 |
| Barton, JC | 1 |
| Ward, HE | 1 |
| Hicks, M | 1 |
| Nicholson, A | 1 |
| Berend, N | 1 |
| Bentur, Y | 1 |
| Koren, G | 1 |
2 reviews available for deferoxamine and Pulmonary Fibrosis
| Article | Year |
|---|---|
Recent advances in particulate-induced pulmonary fibrosis; for the application of possible strategy experimentally and clinically.
Topics: Adrenal Cortex Hormones; Animals; Antioxidants; Blood Proteins; Chelating Agents; Cytokines; Deferox | 2000 |
Biological and toxic properties of deferoxamine.
Topics: Cataract; Cell Division; Deferoxamine; DNA; Drug Hypersensitivity; Hearing Disorders; Humans; Pulmon | 1989 |
9 other studies available for deferoxamine and Pulmonary Fibrosis
| Article | Year |
|---|---|
Iron deposition-induced ferroptosis in alveolar type II cells promotes the development of pulmonary fibrosis.
Topics: Animals; Bleomycin; Cation Transport Proteins; Deferoxamine; Disease Models, Animal; Ferroptosis; Ge | 2021 |
Serum indicators of free radical activity in idiopathic pulmonary fibrosis.
Topics: Aged; Antibodies, Antinuclear; C-Reactive Protein; Deferoxamine; Disease Progression; Female; Free R | 1996 |
Pulmonary syndrome and intravenous high-dose desferrioxamine.
Topics: Adolescent; Child; Deferoxamine; Humans; Infusions, Intravenous; Pulmonary Fibrosis; Thalassemia | 1990 |
Pulmonary syndrome in patients with thalassemia major receiving intravenous deferoxamine infusions.
Topics: Adolescent; Adult; Child; Child, Preschool; Deferoxamine; Drug Hypersensitivity; Female; Humans; Imm | 1990 |
Deferoxamine injection does not affect bleomycin-induced lung fibrosis in rats.
Topics: Animals; Bleomycin; Body Weight; Collagen; Deferoxamine; Lung; Male; Organ Size; Pulmonary Fibrosis; | 1985 |
Reduction in bleomycin-induced lung hydroxyproline content by an iron chelating agent.
Topics: Animals; Bleomycin; Chelating Agents; Cricetinae; Deferoxamine; Hydroxyproline; Iron; Lung; Male; Me | 1986 |
Modulation of the development of bleomycin-induced fibrosis by deferoxamine.
Topics: Animals; Bleomycin; Collagen; Cricetinae; Deferoxamine; Hydroxides; Hydroxyl Radical; Lipid Peroxide | 1988 |
Deferoxamine infusion does not inhibit bleomycin-induced lung damage in the rat.
Topics: Animals; Bleomycin; Deferoxamine; Infusion Pumps; Iron; Lung; Lung Diseases; Osmolar Concentration; | 1988 |
The effect of deferoxamine on bleomycin-induced lung fibrosis in the hamster.
Topics: Animals; Bleomycin; Collagen; Cricetinae; Deferoxamine; Lung; Lymphocytes; Male; Mesocricetus; Pulmo | 1985 |