deferoxamine has been researched along with Proteinuria in 12 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Proteinuria: The presence of proteins in the urine, an indicator of KIDNEY DISEASES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "There are limited studies on renal involvement in beta-thalassemia, mainly involving patients on deferoxamine, reporting both glomerular and tubular dysfunction." | 7.76 | Renal dysfunction in patients with beta-thalassemia major receiving iron chelation therapy either with deferoxamine and deferiprone or with deferasirox. ( Athanassiou-Metaxa, M; Economou, M; Papachristou, F; Printza, N; Teli, A; Tsatra, I; Tzimouli, V, 2010) |
| "A single intravenous injection of puromycin aminonucleoside (PAN) results in marked proteinuria and glomerular morphological changes that are similar to minimal change disease in humans." | 7.67 | Evidence suggesting a role for hydroxyl radical in puromycin aminonucleoside-induced proteinuria. ( Shah, SV; Thakur, V; Walker, PD, 1988) |
| "There are limited studies on renal involvement in beta-thalassemia, mainly involving patients on deferoxamine, reporting both glomerular and tubular dysfunction." | 3.76 | Renal dysfunction in patients with beta-thalassemia major receiving iron chelation therapy either with deferoxamine and deferiprone or with deferasirox. ( Athanassiou-Metaxa, M; Economou, M; Papachristou, F; Printza, N; Teli, A; Tsatra, I; Tzimouli, V, 2010) |
| " In a separate in vivo study, the iron chelator, deferoxamine, prevented the increase in the bleomycin-detectable iron in glomeruli and provided complete protection against proteinuria." | 3.69 | Role of 'catalytic' iron in an animal model of minimal change nephrotic syndrome. ( Baliga, R; Shah, SV; Ueda, N, 1996) |
| "A single intravenous injection of puromycin aminonucleoside (PAN) results in marked proteinuria and glomerular morphological changes that are similar to minimal change disease in humans." | 3.67 | Evidence suggesting a role for hydroxyl radical in puromycin aminonucleoside-induced proteinuria. ( Shah, SV; Thakur, V; Walker, PD, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (50.00) | 18.7374 |
| 1990's | 4 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gelosa, P | 1 |
| Pignieri, A | 1 |
| Gianazza, E | 1 |
| Criniti, S | 1 |
| Guerrini, U | 1 |
| Cappellini, MD | 1 |
| Banfi, C | 1 |
| Tremoli, E | 1 |
| Sironi, L | 1 |
| Economou, M | 1 |
| Printza, N | 1 |
| Teli, A | 1 |
| Tzimouli, V | 1 |
| Tsatra, I | 1 |
| Papachristou, F | 1 |
| Athanassiou-Metaxa, M | 1 |
| Nankivell, BJ | 1 |
| Chen, J | 1 |
| Boadle, RA | 1 |
| Harris, DC | 1 |
| Ueda, N | 1 |
| Baliga, R | 1 |
| Shah, SV | 3 |
| Sumboonnanonda, A | 1 |
| Malasit, P | 1 |
| Tanphaichitr, VS | 1 |
| Ong-ajyooth, S | 1 |
| Sunthornchart, S | 1 |
| Pattanakitsakul, S | 1 |
| Petrarat, S | 1 |
| Assateerawatt, A | 1 |
| Vongjirad, A | 1 |
| Yoshioka, T | 1 |
| Ichikawa, I | 1 |
| Fogo, A | 1 |
| Rehan, A | 1 |
| Wiggins, RC | 1 |
| Kunkel, RG | 1 |
| Till, GO | 1 |
| Johnson, KJ | 1 |
| Thakur, V | 1 |
| Walker, PD | 1 |
| Ploeg, RJ | 1 |
| Vreugdenhil, P | 1 |
| Goossens, D | 1 |
| McAnulty, JF | 1 |
| Southard, JH | 1 |
| Belzer, FO | 1 |
| Boyce, NW | 1 |
| Holdsworth, SR | 1 |
| Dagg, JH | 1 |
| Smith, JA | 1 |
| Goldberg, A | 1 |
1 trial available for deferoxamine and Proteinuria
| Article | Year |
|---|---|
Renal tubular function in beta-thalassemia.
Topics: Adolescent; Amino Acids; beta-Thalassemia; Blood Transfusion; Child; Child, Preschool; Deferoxamine; | 1998 |
11 other studies available for deferoxamine and Proteinuria
| Article | Year |
|---|---|
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats.
Topics: Animals; Blood Pressure; Deferoxamine; Disease Models, Animal; Hemolysis; Homeostasis; Hypertension, | 2013 |
Renal dysfunction in patients with beta-thalassemia major receiving iron chelation therapy either with deferoxamine and deferiprone or with deferasirox.
Topics: Adolescent; Adult; Benzoates; beta 2-Microglobulin; beta-Thalassemia; Biomarkers; Chelation Therapy; | 2010 |
The role of tubular iron accumulation in the remnant kidney.
Topics: Animals; Creatinine; Deferoxamine; Disease Models, Animal; Electron Probe Microanalysis; Ferric Comp | 1994 |
Role of 'catalytic' iron in an animal model of minimal change nephrotic syndrome.
Topics: Animals; Bleomycin; Deferoxamine; Disease Models, Animal; Iron; Kidney Glomerulus; Kidney Tubules; M | 1996 |
Reactive oxygen metabolites cause massive, reversible proteinuria and glomerular sieving defect without apparent ultrastructural abnormality.
Topics: Animals; Catalase; Deferoxamine; Dextrans; Free Radicals; Hydrogen Peroxide; Kidney Glomerulus; Male | 1991 |
Glomerular injury and proteinuria in rats after intrarenal injection of cobra venom factor. Evidence for the role of neutrophil-derived oxygen free radicals.
Topics: Animals; Catalase; Complement Activation; Deferoxamine; Dimethyl Sulfoxide; Elapid Venoms; Free Radi | 1986 |
Evidence suggesting a role for hydroxyl radical in passive Heymann nephritis in rats.
Topics: Animals; Antibodies, Anti-Idiotypic; Benzoates; Benzoic Acid; Deferoxamine; Free Radicals; Hydroxide | 1988 |
Evidence suggesting a role for hydroxyl radical in puromycin aminonucleoside-induced proteinuria.
Topics: Animals; Benzoates; Benzoic Acid; Deferoxamine; Dimethyl Sulfoxide; Hydroxides; Hydroxyl Radical; Ma | 1988 |
Effect of pharmacologic agents on the function of the hypothermically preserved dog kidney during normothermic reperfusion.
Topics: Allopurinol; Animals; Ca(2+) Mg(2+)-ATPase; Calcium-Transporting ATPases; Catalase; Cold Temperature | 1988 |
Hydroxyl radical mediation of immune renal injury by desferrioxamine.
Topics: Acute Kidney Injury; Animals; Antibodies; Basement Membrane; Deferoxamine; Dose-Response Relationshi | 1986 |
Urinary excretion of iron.
Topics: Adolescent; Adult; Aged; Anemia, Hypochromic; Animals; Child; Deferoxamine; Female; Hemoglobinuria; | 1966 |