deferoxamine has been researched along with Primary Myelofibrosis in 8 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Primary Myelofibrosis: A de novo myeloproliferation arising from an abnormal stem cell. It is characterized by the replacement of bone marrow by fibrous tissue, a process that is mediated by CYTOKINES arising from the abnormal clone.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Adult patients with transfusional hemosiderosis were given ascorbic acid and treated with the iron chelator, desferrioxamine B." | 3.65 | Treatment of iron overload in adults with continuous parenteral desferrioxamine. ( Bunn, HF; Cooper, B; Moloney, WC; Nathan, DG; Propper, RD; Rosenthal, DS, 1977) |
| "Here, we discuss a patient with primary myelofibrosis and related transfusion-dependent anemia who received chelation therapy with the once-daily oral iron chelator, deferasirox." | 1.34 | Correction of anemia in a transfusion-dependent patient with primary myelofibrosis receiving iron chelation therapy with deferasirox (Exjade, ICL670). ( Alberti, D; Angelucci, E; Deplano, S; Di Tucci, AA; Murru, R; Rabault, B, 2007) |
| "Acute myelofibrosis (AMF) was diagnosed in a 59-yr-old black male in September 1978, on the basis of pancytopenia, lack of hepatosplenomegaly, fibrosis of the marrow, and paucity of teardrop red blood cells in the peripheral blood." | 1.26 | Karyotypic polymorphism in acute myelofibrosis. ( Koppitch, F; Mahmood, S; Mayeda, K; Nemitz, B; Shah, I, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (62.50) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| UNSELD, DW | 1 |
| Di Tucci, AA | 1 |
| Murru, R | 1 |
| Alberti, D | 1 |
| Rabault, B | 1 |
| Deplano, S | 1 |
| Angelucci, E | 1 |
| Shah, I | 1 |
| Mayeda, K | 1 |
| Koppitch, F | 1 |
| Mahmood, S | 1 |
| Nemitz, B | 1 |
| Lewinski, UH | 1 |
| Floru, S | 1 |
| Cohen, AM | 1 |
| Mittelmann, M | 1 |
| Cooper, B | 2 |
| Bunn, HF | 2 |
| Propper, RD | 2 |
| Nathan, DG | 2 |
| Rosenthal, DS | 2 |
| Moloney, WC | 2 |
| Marsh, JH | 1 |
| Hundert, M | 1 |
| Schulman, P | 1 |
| Bianco, G | 1 |
| Gallo, E | 1 |
| Ramello, A | 1 |
| Ricco, G | 1 |
| Matone, S | 1 |
8 other studies available for deferoxamine and Primary Myelofibrosis
| Article | Year |
|---|---|
[A NEW TEST ("DESFERAL TEST") FOR THE DEMONSTRATION OF PATHOLOGICAL IRON DEPOSITS IN THE ORGANISM].
Topics: Deferoxamine; Diagnosis, Differential; Hemochromatosis; Hemosiderosis; Hepatitis; Hepatitis A; Human | 1964 |
Correction of anemia in a transfusion-dependent patient with primary myelofibrosis receiving iron chelation therapy with deferasirox (Exjade, ICL670).
Topics: Anemia; Blood Transfusion; Deferoxamine; Humans; Iron Chelating Agents; Primary Myelofibrosis | 2007 |
Karyotypic polymorphism in acute myelofibrosis.
Topics: Acute Disease; Blood Transfusion; Bone Marrow Cells; Chromosomes, Human, 1-3; Chromosomes, Human, 4- | 1982 |
Recombinant human erythropoietin in the treatment of myelodysplastic syndromes--response patterns.
Topics: Aged; Aged, 80 and over; Anemia, Refractory; Anemia, Sideroblastic; Blood Transfusion; Chelation The | 1994 |
Treatment of iron overload in adults with continuous parenteral desferrioxamine.
Topics: Adult; Aged; Ascorbic Acid; Biopsy, Needle; Deferoxamine; Female; Ferritins; Hemosiderosis; Humans; | 1977 |
Evaluation of continuous desferrioxamine administration in adults with transfusional hemosiderosis.
Topics: Adult; Anemia, Sideroblastic; Ascorbic Acid; Deferoxamine; Drug Administration Schedule; Female; Hem | 1977 |
Deferoxamine-induced restoration of haematopoiesis in myelofibrosis secondary to myelodysplasia.
Topics: Aged; Deferoxamine; Hematopoiesis; Humans; Male; Myelodysplastic Syndromes; Primary Myelofibrosis | 1990 |
[Therapy of primary siderochromatosis and siderosis: experimental and clinical study].
Topics: Bloodletting; Deferoxamine; Hemochromatosis; Humans; Intestinal Absorption; Iron; Porphyrias; Primar | 1969 |