deferoxamine has been researched along with Porphyrias in 54 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Porphyrias: A diverse group of metabolic diseases characterized by errors in the biosynthetic pathway of HEME in the LIVER, the BONE MARROW, or both. They are classified by the deficiency of specific enzymes, the tissue site of enzyme defect, or the clinical features that include neurological (acute) or cutaneous (skin lesions). Porphyrias can be hereditary or acquired as a result of toxicity to the hepatic or erythropoietic marrow tissues.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The purpose of the present work is to investigate the ability of desferrioxamine (DF) as an iron chelator to revert or decrease a severe experimental porphyria induced by hexachlorobenzene (HCB) in rats; DF treatment started after 17 weeks of HCB intoxication and was continued until the 27th week." | 7.67 | [Evaluation of deferoxamine capacity to revert a severe porphyria induced by hexachlorobenzene]. ( Aldonatti, CA; Billi, SC; San Martín de Viale, LC; Wainstok de Calmanovici, R, 1987) |
| "The effect of desferrioxamine on hexachlorobenzene (HCB)-induced porphyria was studied in female rats in order to investigate the role of iron in the development of this porphyria." | 7.67 | Effect of an iron chelator on the onset of hexachlorobenzene-induced porphyria in rats. ( Aldonatti, CA; Billi, SC; San Martín de Viale, LC; Wainstok de Calmanovici, R, 1986) |
| "The present work deals with the effect of desferrioxamine (DF) on hexachlorobenzene (HCB)-induced porphyria in female rats with the purpose of further investigation of the role of iron in the development of this porphyria." | 7.67 | Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria. ( Aldonatti, CA; Billi, SC; San Martín de Viale, LC; Wainstock de Calmanovici, R, 1986) |
| "Porphyria was induced in vivo in mice using 3,5-diethoxycarbonyl-1,4-dihydrocollidine or in vitro by exposing human liver Huh7 cells and keratinocytes, or their lysates, to protoporphyrin-IX, other porphyrins, or to δ-aminolevulinic acid plus deferoxamine." | 3.91 | Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells. ( Basrur, V; Carter, EL; Herrmann, H; Lehnert, N; Maitra, D; Nesvizhskii, AI; Omary, MB; Osawa, Y; Ragsdale, SW; Richardson, R; Rittié, L; Wolf, MW; Zhang, H, 2019) |
| "The purpose of the present work is to investigate the ability of desferrioxamine (DF) as an iron chelator to revert or decrease a severe experimental porphyria induced by hexachlorobenzene (HCB) in rats; DF treatment started after 17 weeks of HCB intoxication and was continued until the 27th week." | 3.67 | [Evaluation of deferoxamine capacity to revert a severe porphyria induced by hexachlorobenzene]. ( Aldonatti, CA; Billi, SC; San Martín de Viale, LC; Wainstok de Calmanovici, R, 1987) |
| "The effect of desferrioxamine on hexachlorobenzene (HCB)-induced porphyria was studied in female rats in order to investigate the role of iron in the development of this porphyria." | 3.67 | Effect of an iron chelator on the onset of hexachlorobenzene-induced porphyria in rats. ( Aldonatti, CA; Billi, SC; San Martín de Viale, LC; Wainstok de Calmanovici, R, 1986) |
| "The present work deals with the effect of desferrioxamine (DF) on hexachlorobenzene (HCB)-induced porphyria in female rats with the purpose of further investigation of the role of iron in the development of this porphyria." | 3.67 | Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria. ( Aldonatti, CA; Billi, SC; San Martín de Viale, LC; Wainstock de Calmanovici, R, 1986) |
| "Hemochromatosis is a syndrome which, when fully expressed, is manifested by melanoderma , diabetes mellitus, and liver cirrhosis, with iron overload involving parenchymal and reticuloendothelial cells in many organ systems." | 2.36 | Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy. ( Kellermeyer, RW; McLaren, GD; Muir, WA, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 45 (83.33) | 18.7374 |
| 1990's | 8 (14.81) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (1.85) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Maitra, D | 1 |
| Carter, EL | 1 |
| Richardson, R | 1 |
| Rittié, L | 1 |
| Basrur, V | 1 |
| Zhang, H | 1 |
| Nesvizhskii, AI | 1 |
| Osawa, Y | 1 |
| Wolf, MW | 1 |
| Ragsdale, SW | 1 |
| Lehnert, N | 1 |
| Herrmann, H | 1 |
| Omary, MB | 1 |
| HOLZMANN, H | 1 |
| SAUNDERS, SJ | 1 |
| VENTURA, S | 1 |
| COLI, L | 1 |
| WOEHLER, F | 1 |
| Beurey, J | 2 |
| Weber, M | 2 |
| Montet, Y | 1 |
| Jeandidier, P | 1 |
| Barbier, JM | 1 |
| McLaren, GD | 1 |
| Muir, WA | 1 |
| Kellermeyer, RW | 1 |
| Marchesi, L | 1 |
| Di Padova, C | 1 |
| Cainelli, T | 1 |
| Reseghetti, A | 1 |
| Di Padova, F | 1 |
| Rovagnati, P | 1 |
| Cantoni, L | 1 |
| Gibertini, P | 4 |
| Rocchi, E | 6 |
| Cassanelli, M | 6 |
| Pietrangelo, A | 4 |
| Ventura, E | 6 |
| Halliday, JW | 1 |
| Bassett, ML | 1 |
| Lim, LK | 1 |
| Srivastava, G | 1 |
| Brooker, JD | 1 |
| May, BK | 1 |
| Elliott, WH | 1 |
| van Gelder, W | 1 |
| Siersema, PD | 1 |
| Voogd, A | 1 |
| de Jeu-Jaspars, NC | 1 |
| van Eijk, HG | 2 |
| Koster, JF | 1 |
| de Rooy, FW | 1 |
| Wilson, JH | 1 |
| Hahn, M | 1 |
| Gildemeister, OS | 1 |
| Krauss, GL | 1 |
| Pepe, JA | 1 |
| Lambrecht, RW | 2 |
| Donohue, S | 1 |
| Bonkovsky, HL | 2 |
| Kautzsch, E | 1 |
| Piazza, V | 1 |
| Villa, G | 1 |
| Galli, F | 1 |
| Segagni, S | 1 |
| Bovio, G | 1 |
| Poggio, F | 1 |
| Picardi, L | 1 |
| Bianco, L | 1 |
| Salvadeo, A | 1 |
| Barosi, G | 1 |
| Toriyama, T | 1 |
| Kawahara, H | 1 |
| Cable, EE | 1 |
| Cable, JW | 1 |
| Donohue, SE | 1 |
| White, EC | 1 |
| Greene, YJ | 1 |
| Srivastava, KK | 1 |
| Arnold, WN | 1 |
| Borghi, A | 3 |
| Paolillo, F | 1 |
| Pradelli, M | 1 |
| Pellizzardi, S | 1 |
| Vezzosi, A | 1 |
| Gallo, E | 2 |
| Baccarani Contri, M | 1 |
| Stockenhuber, F | 1 |
| Kurz, R | 1 |
| Grimm, G | 1 |
| Moser, G | 1 |
| Balcke, P | 1 |
| Muñoz, JJ | 1 |
| Garcia-Cabezas, J | 1 |
| Martinez-Verano, J | 1 |
| Perez-Oteyza, C | 1 |
| Enriquez de Salamanca, R | 2 |
| De Matteis, F | 1 |
| Harvey, C | 1 |
| Reed, C | 1 |
| Hempenius, R | 1 |
| Wainstok de Calmanovici, R | 2 |
| Billi, SC | 3 |
| Aldonatti, CA | 3 |
| San Martín de Viale, LC | 3 |
| Pantaleoni, M | 1 |
| Jensen, J | 1 |
| Wainstock de Calmanovici, R | 1 |
| Praga, M | 1 |
| Andres, A | 1 |
| Nieto, J | 1 |
| Oliet, A | 1 |
| Perpiña, J | 1 |
| Morales, JM | 1 |
| Bobeck-Rutsaert, MM | 1 |
| Wiltink, WF | 1 |
| den Kelder M, OP | 1 |
| Leijnse, B | 1 |
| Cumming, RL | 1 |
| Goldberg, A | 1 |
| Morrow, J | 1 |
| Smith, JA | 1 |
| Gheorghiu, G | 1 |
| Forsea, D | 1 |
| Nozicková, M | 2 |
| Storck, H | 1 |
| Schwarz, K | 1 |
| Ott, F | 1 |
| Dyerberg, J | 1 |
| Turnbull, A | 1 |
| Thivolet, J | 3 |
| Bondet, P | 2 |
| Perrot, H | 3 |
| Moene, Y | 2 |
| Mallein, R | 1 |
| Sabater, P | 1 |
| Burg, G | 2 |
| Wöhler, F | 1 |
| Taxay, EP | 1 |
| Taljaard, JJ | 1 |
| Shanley, BC | 1 |
| Stewart-Wynne, EG | 1 |
| Deppe, WM | 1 |
| Joubert, SM | 1 |
| Haneke, E | 1 |
| Schwartze, G | 1 |
| Horvat, Z | 1 |
| Bakran, I | 1 |
| Radosević, Z | 1 |
| Votruba, M | 1 |
| Pazderka, J | 1 |
| Bianco, G | 2 |
| Ramello, A | 1 |
| Ricco, G | 1 |
| Matone, S | 1 |
| Walsh, JR | 1 |
| Lobitz, WC | 1 |
| Mahler, DJ | 1 |
| Kingery, FA | 1 |
| Barth, J | 1 |
| Petter, O | 1 |
| Amerio, PL | 1 |
| Garcovich, A | 1 |
| Ormea, F | 1 |
| Gurecki, H | 1 |
| Perello, R | 1 |
| Vadot, J | 1 |
| Schnack, H | 1 |
| Wewalka, F | 1 |
| Mazza, U | 1 |
| Fiorina, L | 1 |
| Prato, V | 1 |
3 reviews available for deferoxamine and Porphyrias
| Article | Year |
|---|---|
Iron overload disorders: natural history, pathogenesis, diagnosis, and therapy.
Topics: Anemia, Hypochromic; Biological Transport; Bloodletting; Chelating Agents; Deferoxamine; Disease Mod | 1983 |
[Deferoxamine-B, a ferriuretic chelate].
Topics: Anemia, Hypochromic; Chemical Phenomena; Chemistry; Deferoxamine; Hemochromatosis; Hemosiderosis; Hu | 1967 |
Iron metabolism in the porphyrias.
Topics: Alcohol Drinking; Amino Acids; Anemia, Hemolytic; Bloodletting; Bone Marrow; Bone Marrow Diseases; D | 1971 |
1 trial available for deferoxamine and Porphyrias
| Article | Year |
|---|---|
A comparative trial of desferrioxamine and hydroxychloroquine for treatment of porphyria cutanea tarda in alcoholic patients.
Topics: Adult; Alcoholism; Clinical Trials as Topic; Deferoxamine; Ferritins; Humans; Hydroxychloroquine; Ir | 1984 |
50 other studies available for deferoxamine and Porphyrias
| Article | Year |
|---|---|
Oxygen and Conformation Dependent Protein Oxidation and Aggregation by Porphyrins in Hepatocytes and Light-Exposed Cells.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Hepatocellular; Cell Line; Deferoxamine; Heme; Hepatocytes; | 2019 |
[On the use of desferrioxamine in porphyria cutanea tarda].
Topics: Animals; Chelating Agents; Deferoxamine; Humans; Hydroxamic Acids; Porifera; Porphyria Cutanea Tarda | 1963 |
IRON METABOLISM IN SYMPTOMATIC PORPHYRIA. A PRELIMINARY COMMUNICATION.
Topics: Alcoholism; Blood Chemical Analysis; Chelating Agents; Deferoxamine; Feces; Hemochromatosis; Hexachl | 1963 |
[RESEARCH ON DESFERRIOXAMINE B. 3. THE CLINICAL USE OF DESFERRIOXAMINE B].
Topics: Anemia; Anemia, Hemolytic; Anemia, Macrocytic; Deferoxamine; Hematologic Diseases; Hemochromatosis; | 1964 |
[TREATMENT OF HEMOCHROMATOSIS].
Topics: Deferoxamine; Drug Therapy; Hemochromatosis; Hemosiderosis; Humans; Porphyrias; Thalassemia | 1965 |
[Porphyria cutanea tarda with hypersideremia: effectiveness of desferrioxamine (Desferal)].
Topics: Deferoxamine; Diagnosis, Differential; Hemochromatosis; Humans; Iron; Male; Middle Aged; Porphyrias | 1966 |
Porphyria cutanea tarda in beta-thalassemia trait carriers.
Topics: Adult; Deferoxamine; Heterozygote; Humans; Liver Diseases; Male; Middle Aged; Porphyrias; Skin Disea | 1984 |
Advances in the treatment of porphyria cutanea tarda. Effectiveness of slow subcutaneous desferrioxamine infusion.
Topics: Adult; Aged; Deferoxamine; Humans; Infusions, Parenteral; Injections, Subcutaneous; Middle Aged; Por | 1984 |
Treatment of iron storage disorders.
Topics: Anemia; Deferoxamine; Hemochromatosis; Humans; Iron; Liver Cirrhosis; Porphyrias; Skin Diseases; Tha | 1980 |
Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.
Topics: 5-Aminolevulinate Synthetase; Allylisopropylacetamide; Animals; Chick Embryo; Cytochrome P-450 Enzym | 1980 |
The effect of desferrioxamine on iron metabolism and lipid peroxidation in hepatocytes of C57BL/10 mice in experimental uroporphyria.
Topics: Animals; Deferoxamine; Iron; Lipid Peroxidation; Liver; Male; Malondialdehyde; Mice; Mice, Inbred C5 | 1993 |
Effects of new anticonvulsant medications on porphyrin synthesis in cultured liver cells: potential implications for patients with acute porphyria.
Topics: Animals; Cells, Cultured; Chick Embryo; Deferoxamine; Dose-Response Relationship, Drug; Liver; Pheno | 1997 |
[Letter: Therapy of hemochromatosis].
Topics: Bloodletting; Deferoxamine; Hemochromatosis; Humans; Porphyrias; Siderosis | 1975 |
Erythropoietin as treatment of haemodialysis-related porphyria cutanea tarda.
Topics: Aged; Deferoxamine; Erythrocytes; Erythropoietin; Humans; Iron; Male; Porphyrias; Porphyrins; Protop | 1992 |
[Small volume plasma exchange therapy in patients with porphyria cutanea tarda on maintenance hemodialysis].
Topics: Deferoxamine; Erythropoietin; Humans; Kidney Diseases; Male; Middle Aged; Plasma Exchange; Porphyria | 1992 |
Porphyrogenic properties of the terpenes camphor, pinene, and thujone (with a note on historic implications for absinthe and the illness of Vincent van Gogh).
Topics: 5-Aminolevulinate Synthetase; Alcoholic Beverages; Animals; Bicyclic Monoterpenes; Camphor; Cells, C | 1992 |
Liver iron overload and desferrioxamine treatment of porphyria cutanea tarda.
Topics: Bloodletting; Chromatography, High Pressure Liquid; Chronic Disease; Deferoxamine; Ferritins; Humans | 1991 |
Successful treatment of hemodialysis-related porphyria cutanea tarda with deferoxamine.
Topics: Deferoxamine; Female; Humans; Middle Aged; Porphyrias; Renal Dialysis; Skin Diseases | 1990 |
Desferrioxamine in the treatment of porphyria cutanea tarda: ineffectiveness of intramuscular administration.
Topics: Adult; Deferoxamine; Humans; Injections, Intramuscular; Male; Middle Aged; Porphyrias; Skin Diseases | 1990 |
Increased oxidation of uroporphyrinogen by an inducible liver microsomal system. Possible relevance to drug-induced uroporphyria.
Topics: Aminolevulinic Acid; Animals; Benzoflavones; Cells, Cultured; Chick Embryo; Cytochrome P-450 CYP1A1; | 1988 |
[Evaluation of deferoxamine capacity to revert a severe porphyria induced by hexachlorobenzene].
Topics: 5-Aminolevulinate Synthetase; Animals; Carboxy-Lyases; Deferoxamine; Hexachlorobenzene; Liver; Porph | 1987 |
Effect of an iron chelator on the onset of hexachlorobenzene-induced porphyria in rats.
Topics: 5-Aminolevulinate Synthetase; Animals; Carboxy-Lyases; Chlorobenzenes; Deferoxamine; Enzyme Inductio | 1986 |
High weekly intravenous doses of desferrioxamine in porphyria cutanea tarda.
Topics: Aged; Deferoxamine; Dose-Response Relationship, Drug; Humans; Infusions, Intravenous; Male; Middle A | 1987 |
Iron removal therapy in porphyria cutanea tarda: phlebotomy versus slow subcutaneous desferrioxamine infusion.
Topics: Adult; Bloodletting; Deferoxamine; Female; Humans; Infusions, Parenteral; Iron; Male; Middle Aged; P | 1986 |
Effect of desferrioxamine on the development of hexachlorobenzene-induced porphyria.
Topics: 5-Aminolevulinate Synthetase; Animals; Body Weight; Carboxy-Lyases; Chlorobenzenes; Deferoxamine; Di | 1986 |
Treatment of hemodialysis-related porphyria cutanea tarda with deferoxamine.
Topics: Adult; Deferoxamine; Humans; Male; Porphyrias; Renal Dialysis; Skin Diseases | 1987 |
Serum ferritin in the assessment of liver iron overload and iron removal therapy in porphyria cutanea tarda.
Topics: Adult; Deferoxamine; Female; Ferritins; Humans; Iron; Liver; Male; Middle Aged; Porphyrias; Skin Dis | 1986 |
Measurement of the labile Iron stores with Singh's technique and chemical determination of Iron contents in organs of rats.
Topics: Animals; Brain Chemistry; Deferoxamine; Erythrocytes; Humans; Iron; Iron Radioisotopes; Kidney; Live | 1973 |
Effect of phenylhydrazine-induced haemolysis on the urinary excretion of iron after desferrioxamine.
Topics: Anemia, Sideroblastic; Animals; Biopsy; Bone Marrow Examination; Deferoxamine; Feces; Guinea Pigs; H | 1967 |
[Treatment of cutaneous porphyrias].
Topics: Adrenocorticotropic Hormone; Anabolic Agents; Deferoxamine; Edetic Acid; Humans; Porphyrias; Skin Di | 1968 |
Biochemical effects of chelation therapy using deferoxamine mesylate on experimental porphyria in rats.
Topics: Animals; Deferoxamine; Male; Porphyrias; Rats | 1972 |
[A case of porphyria cutanea tarda in a 5-year-old child].
Topics: Alkaline Phosphatase; Child, Preschool; Deferoxamine; Humans; Male; Porphyrias; Porphyrins; Transami | 1972 |
[Treatment of late cutaneous porphyrias with iron chelating agents (EDTA, Desferral)].
Topics: Adult; Deferoxamine; Edetic Acid; Humans; Male; Middle Aged; Porphyrias; Skin Diseases | 1967 |
[Clinical and biological effects of chelating agents in porphyria cutanea tarda].
Topics: Adult; Aged; Deferoxamine; Edetic Acid; Feces; Humans; Male; Middle Aged; Porphyrias; Porphyrins | 1968 |
[Treatment of porphyria cutanea tarda by iron chelators (EDTA, Desferral)].
Topics: Adult; Deferoxamine; Edetic Acid; Humans; Male; Middle Aged; Porphyrias | 1967 |
[Therapy of porphyrias].
Topics: Acute Disease; Adenine Nucleotides; Antimalarials; Bicarbonates; Bloodletting; Deferoxamine; Diet Th | 1971 |
Diagnosis of iron storage disease with desferrioxamine (Desferal test).
Topics: Anemia, Macrocytic; Anemia, Sickle Cell; Deferoxamine; Female; Hemochromatosis; Hemosiderosis; Human | 1964 |
[Therapy of porphyrias].
Topics: Acute Disease; Bone Marrow Diseases; Chlorpromazine; Deferoxamine; Erythropoiesis; Humans; Phospholi | 1972 |
Deferoxamine in the treatment of porphyria.
Topics: Deferoxamine; Evaluation Studies as Topic; Female; Hemoglobinometry; Humans; Iron; Levulinic Acids; | 1972 |
Studies on low dose chloroquine therapy and the action of chloroquine in symptomatic porphyria.
Topics: Adult; Animals; Aspartate Aminotransferases; Carbon Tetrachloride; Chloroquine; Deferoxamine; Humans | 1972 |
[Experiences with iron elimination therapy in porphyria cutanea tarda].
Topics: Adult; Bloodletting; Deferoxamine; Female; Humans; Iron; Liver Diseases; Male; Middle Aged; Porphyri | 1971 |
[Treatment of late cutaneous porphyria by desferal].
Topics: Deferoxamine; Female; Humans; Middle Aged; Porphyrias; Skin Diseases | 1969 |
[Quantitative determination of urinary porphyrins using Rimington's and Sveinsson's technic and experience in the therapy of porphyria cutanea tarda using Desferal CIBA].
Topics: Deferoxamine; Fluorometry; Humans; Methods; Porphyrias; Porphyrins; Spectrophotometry | 1969 |
[Therapy of primary siderochromatosis and siderosis: experimental and clinical study].
Topics: Bloodletting; Deferoxamine; Hemochromatosis; Humans; Intestinal Absorption; Iron; Porphyrias; Primar | 1969 |
Phlebotomy therapy in cutaneous porphyria. Effect on iron and trace metals.
Topics: Aged; Bloodletting; Copper; Deferoxamine; Hematopoiesis; Humans; Iron; Liver Function Tests; Magnesi | 1970 |
[Catamnestic studies in porphyria cutanea tarda with special reference to therapy].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adult; Aged; Bloodletting; Deferoxamine; Diabetes Compl | 1971 |
[Treatment of porphyria cutanea tarda with desferrioxamine (Desferal)].
Topics: Deferoxamine; Humans; Male; Porphyrias | 1967 |
[Favorable clinical and biological action of iron chelator in 4 cases of porphyria cutanea tarda. Attempts at interpretation].
Topics: Adult; Aged; Alcoholism; Deferoxamine; Humans; Male; Porphyrias; Siderosis; Skin Diseases | 1968 |
[Demonstration of increased iron storage in the organism with desferrioxamine (desferal test)].
Topics: Deferoxamine; Hemochromatosis; Hemosiderosis; Humans; Iron; Jaundice; Liver Diseases; Porphyrias | 1965 |
[Porphyria cutanea tarda: study of the changes in porphyrin metabolism during desferrioxamine therapy].
Topics: Deferoxamine; Humans; Porphyrias; Porphyrins | 1965 |