deferoxamine and Plasmodium falciparum Malaria studies

deferoxamine and Plasmodium falciparum Malaria

Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

Research Excerpts

Excerpt	Relevance	Reference
"Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity."	6.69	Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. ( Chantharaksri, U; Dangdoungjai, J; Looareesuiwan, S; Pipitaporn, B; Sibmooh, N; Udomsangpetch, R; Wilairatana, P, 2000)
"Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity."	2.69	Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. ( Chantharaksri, U; Dangdoungjai, J; Looareesuiwan, S; Pipitaporn, B; Sibmooh, N; Udomsangpetch, R; Wilairatana, P, 2000)
"Dexrazoxane was recently approved to protect humans from doxorubucin-induced cardiotoxicity."	1.30	Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. ( Boehme, P; Gordeuk, VR; John, C; Loyevsky, M; Sacci, JB; Weglicki, W, 1999)

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	10 (66.67)	18.2507
2000's	5 (33.33)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

10 (66.67)

18.2507

2000's

5 (33.33)

29.6817

2010's

0 (0.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Gordeuk, VR	6
Loyevsky, M	2
Omari, A	1
Garner, P	1
Pradines, B	1
Tall, A	1
Ramiandrasoa, F	1
Spiegel, A	1
Sokhna, C	1
Fusai, T	1
Mosnier, J	1
Daries, W	1
Trape, JF	1
Kunesch, G	1
Parzy, D	1
Rogier, C	1
Thuma, PE	3
Brittenham, GM	4
Thompson, DF	1
Biemba, G	1
Zulu, S	2
Simwanza, G	2
Kalense, P	1
M'Hango, A	1
Parry, D	2
Poltera, AA	2
Looareesuwan, S	2
Wilairatana, P	2
Vannaphan, S	1
Taylor, TE	1
Meshnick, SR	1
Sacci, JB	1
Boehme, P	1
Weglicki, W	1
John, C	1
Sibmooh, N	1
Pipitaporn, B	1
Dangdoungjai, J	1
Udomsangpetch, R	1
Looareesuiwan, S	1
Chantharaksri, U	1
Fritsche, G	1
Larcher, C	1
Schennach, H	1
Weiss, G	2
Bunnag, D	1
Viravan, C	1
Harinasuta, KT	1
Schindléry, C	1
Wyler, DJ	1
Gangarossa, S	1
Schilirò, G	1
Russo, R	1
Fuchs, D	1
Werner-Felmayer, G	1
Wachter, H	1
Mhangu, A	1
Flesch, G	1

Studies

Gordeuk, VR

Loyevsky, M

Omari, A

Garner, P

Pradines, B

Tall, A

Ramiandrasoa, F

Spiegel, A

Sokhna, C

Fusai, T

Mosnier, J

Daries, W

Trape, JF

Kunesch, G

Parzy, D

Rogier, C

Thuma, PE

Brittenham, GM

Thompson, DF

Biemba, G

Zulu, S

Simwanza, G

Kalense, P

M'Hango, A

Parry, D

Poltera, AA

Looareesuwan, S

Wilairatana, P

Vannaphan, S

Taylor, TE

Meshnick, SR

Sacci, JB

Boehme, P

Weglicki, W

John, C

Sibmooh, N

Pipitaporn, B

Dangdoungjai, J

Udomsangpetch, R

Looareesuiwan, S

Chantharaksri, U

Fritsche, G

Larcher, C

Schennach, H

Weiss, G

Bunnag, D

Viravan, C

Harinasuta, KT

Schindléry, C

Wyler, DJ

Gangarossa, S

Schilirò, G

Russo, R

Fuchs, D

Werner-Felmayer, G

Wachter, H

Mhangu, A

Flesch, G

Reviews

4 reviews available for deferoxamine and Plasmodium falciparum Malaria

Article	Year
Antimalarial effect of iron chelators. Advances in experimental medicine and biology, 2002, Volume: 509 Topics: Animals; Antimalarials; Child; Deferiprone; Deferoxamine; Drug Therapy, Combination; Humans; In Vitr	2002
Malaria in endemic areas. Clinical evidence, 2003, Issue:9 Topics: Antimalarials; Artemether; Artemisinins; Blood Transfusion; Chloroquine; Deferoxamine; Drug Combinat	2003
Iron chelation therapy for malaria. Advances in experimental medicine and biology, 1994, Volume: 356 Topics: Adult; Animals; Deferoxamine; Erythrocytes; Ferritins; Hemoglobins; Humans; Iron; Iron Chelating Age	1994
Deferoxamine treatment of malaria. The Annals of pharmacotherapy, 1994, Volume: 28, Issue:5 Topics: Animals; Chloroquine; Clinical Trials as Topic; Deferoxamine; Drug Resistance; Drug Therapy, Combina	1994

Article

Year

Antimalarial effect of iron chelators.

Advances in experimental medicine and biology, 2002, Volume: 509

Topics: Animals; Antimalarials; Child; Deferiprone; Deferoxamine; Drug Therapy, Combination; Humans; In Vitr

2002

Malaria in endemic areas.

Clinical evidence, 2003, Issue:9

Topics: Antimalarials; Artemether; Artemisinins; Blood Transfusion; Chloroquine; Deferoxamine; Drug Combinat

2003

Iron chelation therapy for malaria.

Advances in experimental medicine and biology, 1994, Volume: 356

Topics: Adult; Animals; Deferoxamine; Erythrocytes; Ferritins; Hemoglobins; Humans; Iron; Iron Chelating Age

1994

Deferoxamine treatment of malaria.

The Annals of pharmacotherapy, 1994, Volume: 28, Issue:5

Topics: Animals; Chloroquine; Clinical Trials as Topic; Deferoxamine; Drug Resistance; Drug Therapy, Combina

1994

Trials

6 trials available for deferoxamine and Plasmodium falciparum Malaria

Article	Year
Iron chelation as a chemotherapeutic strategy for falciparum malaria. The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:2 Topics: Adult; Animals; Deferoxamine; Female; Humans; Infusion Pumps; Malaria, Falciparum; Male; Plasmodium	1993
Co-administration of desferrioxamine B with artesunate in malaria: an assessment of safety and tolerance. Annals of tropical medicine and parasitology, 1996, Volume: 90, Issue:5 Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Deferoxamine; Drug Therapy, Combination;	1996
Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:11 Topics: Animals; Antimalarials; Artemisinins; Artesunate; Cyclic N-Oxides; Deferoxamine; Double-Blind Method	2000
Plasmodicidal effect of desferrioxamine B in human vivax or falciparum malaria from Thailand. Acta tropica, 1992, Volume: 52, Issue:1 Topics: Adult; Deferoxamine; Follow-Up Studies; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Thailand	1992
Bark, weeds, and iron chelators--drugs for malaria. The New England journal of medicine, 1992, Nov-19, Volume: 327, Issue:21 Topics: Antimalarials; Child; Deferoxamine; Humans; Malaria, Cerebral; Malaria, Falciparum	1992
Iron chelation with desferrioxamine B in adults with asymptomatic Plasmodium falciparum parasitemia. Blood, 1992, Jan-15, Volume: 79, Issue:2 Topics: Adolescent; Adult; Animals; Deferoxamine; Erythrocytes; Female; Humans; Iron Chelating Agents; Malar	1992

Article

Year

Iron chelation as a chemotherapeutic strategy for falciparum malaria.

The American journal of tropical medicine and hygiene, 1993, Volume: 48, Issue:2

Topics: Adult; Animals; Deferoxamine; Female; Humans; Infusion Pumps; Malaria, Falciparum; Male; Plasmodium

1993

Co-administration of desferrioxamine B with artesunate in malaria: an assessment of safety and tolerance.

Annals of tropical medicine and parasitology, 1996, Volume: 90, Issue:5

Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Deferoxamine; Drug Therapy, Combination;

1996

Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria.

Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:11

Topics: Animals; Antimalarials; Artemisinins; Artesunate; Cyclic N-Oxides; Deferoxamine; Double-Blind Method

2000

Plasmodicidal effect of desferrioxamine B in human vivax or falciparum malaria from Thailand.

Acta tropica, 1992, Volume: 52, Issue:1

Topics: Adult; Deferoxamine; Follow-Up Studies; Humans; Malaria, Falciparum; Malaria, Vivax; Male; Thailand

1992

Bark, weeds, and iron chelators--drugs for malaria.

The New England journal of medicine, 1992, Nov-19, Volume: 327, Issue:21

Topics: Antimalarials; Child; Deferoxamine; Humans; Malaria, Cerebral; Malaria, Falciparum

1992

Iron chelation with desferrioxamine B in adults with asymptomatic Plasmodium falciparum parasitemia.

Blood, 1992, Jan-15, Volume: 79, Issue:2

Topics: Adolescent; Adult; Animals; Deferoxamine; Erythrocytes; Female; Humans; Iron Chelating Agents; Malar

1992

Other Studies

5 other studies available for deferoxamine and Plasmodium falciparum Malaria

Article	Year
In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum. The Journal of antimicrobial chemotherapy, 2006, Volume: 57, Issue:6 Topics: Animals; Antimalarials; Deferoxamine; Doxycycline; Drug Resistance; Humans; Inhibitory Concentration	2006
Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. Experimental parasitology, 1999, Volume: 91, Issue:2 Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Deferoxamine; Erythrocytes; Ethylene	1999
Regulatory interactions between iron and nitric oxide metabolism for immune defense against Plasmodium falciparum infection. The Journal of infectious diseases, 2001, May-01, Volume: 183, Issue:9 Topics: Animals; Cells, Cultured; Coculture Techniques; Deferoxamine; Erythrocytes; Humans; Interferon-gamma	2001
Desferrioxamine in the treatment of plasmodium falciparum malaria. American journal of hematology, 1992, Volume: 41, Issue:1 Topics: Animals; Child; Deferoxamine; Female; Humans; Malaria, Falciparum	1992
Therapy of Plasmodium falciparum parasitemia with desferrioxamine. Blood, 1992, Aug-01, Volume: 80, Issue:3 Topics: Animals; Deferoxamine; Humans; Interferon-gamma; Malaria, Falciparum; Plasmodium falciparum	1992

Article

Year

In vitro activity of iron-binding compounds against Senegalese isolates of Plasmodium falciparum.

The Journal of antimicrobial chemotherapy, 2006, Volume: 57, Issue:6

Topics: Animals; Antimalarials; Deferoxamine; Doxycycline; Drug Resistance; Humans; Inhibitory Concentration

2006

Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures.

Experimental parasitology, 1999, Volume: 91, Issue:2

Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Deferoxamine; Erythrocytes; Ethylene

1999

Regulatory interactions between iron and nitric oxide metabolism for immune defense against Plasmodium falciparum infection.

The Journal of infectious diseases, 2001, May-01, Volume: 183, Issue:9

Topics: Animals; Cells, Cultured; Coculture Techniques; Deferoxamine; Erythrocytes; Humans; Interferon-gamma

2001

Desferrioxamine in the treatment of plasmodium falciparum malaria.

American journal of hematology, 1992, Volume: 41, Issue:1

Topics: Animals; Child; Deferoxamine; Female; Humans; Malaria, Falciparum

1992

Therapy of Plasmodium falciparum parasitemia with desferrioxamine.

Blood, 1992, Aug-01, Volume: 80, Issue:3

Topics: Animals; Deferoxamine; Humans; Interferon-gamma; Malaria, Falciparum; Plasmodium falciparum

1992