deferoxamine has been researched along with Parasitemia in 5 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Parasitemia: The presence of parasites (especially malarial parasites) in the blood. (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "DFO is known to reduce the intensity of Trypanosoma cruzi infections in mice even during a course of therapy that is not effective in maintaining anaemia or low iron levels." | 1.37 | Trypanosoma cruzi: desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect. ( Arantes, JM; Araújo, MS; Carneiro, CM; de Abreu Vieira, PM; de Carvalho, AT; Elói-Santos, SM; Francisco, AF; Martins-Filho, OA; Pedrosa, ML; Silva, M; Tafuri, WL, 2011) |
| " In the present study, the effects of benznidazole (BZ) therapy in combination with the iron chelator desferrioxamine (DFO) on the development of infection in mice inoculated with Trypanosoma cruzi Y strain have been investigated." | 1.35 | Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice. ( Arantes, JM; Bahia, MT; Carneiro, CM; de Abreu Vieira, PM; de Lana, M; Francisco, AF; Martins, HR; Pedrosa, ML; Silva, M; Tafuri, WL; Veloso, VM, 2008) |
| "Parasitemia was reduced by all three treatment regimens; however, long-term survival was obtained only by treatment with liposomal DFO (days 7 and 8, 400 mg/kg/day)." | 1.30 | Plasmodium vinckei: optimization of desferrioxamine B delivery in the treatment of murine malaria. ( Eling, WM; Hermsen, CC; Postma, NS; Zuidema, J, 1998) |
| "Dexrazoxane was recently approved to protect humans from doxorubucin-induced cardiotoxicity." | 1.30 | Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures. ( Boehme, P; Gordeuk, VR; John, C; Loyevsky, M; Sacci, JB; Weglicki, W, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Francisco, AF | 2 |
| de Abreu Vieira, PM | 2 |
| Arantes, JM | 3 |
| Pedrosa, ML | 3 |
| Martins, HR | 2 |
| Silva, M | 2 |
| Veloso, VM | 2 |
| de Lana, M | 2 |
| Bahia, MT | 2 |
| Tafuri, WL | 3 |
| Carneiro, CM | 3 |
| Araújo, MS | 1 |
| de Carvalho, AT | 1 |
| Martins-Filho, OA | 1 |
| Elói-Santos, SM | 1 |
| Postma, NS | 1 |
| Hermsen, CC | 1 |
| Zuidema, J | 1 |
| Eling, WM | 1 |
| Loyevsky, M | 1 |
| Sacci, JB | 1 |
| Boehme, P | 1 |
| Weglicki, W | 1 |
| John, C | 1 |
| Gordeuk, VR | 1 |
5 other studies available for deferoxamine and Parasitemia
| Article | Year |
|---|---|
Trypanosoma cruzi: effect of benznidazole therapy combined with the iron chelator desferrioxamine in infected mice.
Topics: Analysis of Variance; Animals; Chagas Disease; Deferoxamine; Disease Models, Animal; Drug Therapy, C | 2008 |
Trypanosoma cruzi: desferrioxamine decreases mortality and parasitemia in infected mice through a trypanostatic effect.
Topics: Animals; Blood Cells; Chagas Disease; Deferoxamine; Ferritins; Iron; Male; Mice; Parasitemia; Sidero | 2011 |
Trypanosoma cruzi: treatment with the iron chelator desferrioxamine reduces parasitemia and mortality in experimentally infected mice.
Topics: Animals; Chagas Disease; Deferoxamine; Hemoglobins; Iron; Liver; Male; Mice; Parasitemia; Siderophor | 2007 |
Plasmodium vinckei: optimization of desferrioxamine B delivery in the treatment of murine malaria.
Topics: Animals; Deferoxamine; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Female; In | 1998 |
Plasmodium falciparum and Plasmodium yoelii: effect of the iron chelation prodrug dexrazoxane on in vitro cultures.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Deferoxamine; Erythrocytes; Ethylene | 1999 |