deferoxamine has been researched along with Myocardial Ischemia in 18 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with deferoxamine (10 mg/kg, n = 7) or dimethylthiourea (10 mg/kg, n = 6) decreased net production of HO." | 5.29 | Hydroxyl radical production during myocardial ischemia and reperfusion in cats. ( Fu, LW; Halliwell, B; Longhurst, JC; O'Neill, CA, 1996) |
| " Two studies were conducted to assess the efficacy of the complexes of desferrioxamine with zinc or gallium to prevent this aspect of reperfusion injury." | 3.71 | The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection. ( Berenshtein, E; Chevion, M; Haverich, A; Karck, M; Sturm, C; Tanaka, S, 2001) |
| "Pretreatment with deferoxamine (10 mg/kg, n = 7) or dimethylthiourea (10 mg/kg, n = 6) decreased net production of HO." | 1.29 | Hydroxyl radical production during myocardial ischemia and reperfusion in cats. ( Fu, LW; Halliwell, B; Longhurst, JC; O'Neill, CA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (77.78) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, H | 1 |
| You, J | 1 |
| Yao, X | 1 |
| Lu, Q | 1 |
| Guo, W | 1 |
| Shen, Y | 1 |
| Yuan, C | 1 |
| Wang, H | 1 |
| Yuan, Z | 1 |
| Huang, HS | 1 |
| Pan, HL | 1 |
| Stahl, GL | 1 |
| Longhurst, JC | 2 |
| Eicher, JC | 1 |
| Gabrielle, F | 1 |
| Abadie, C | 1 |
| Maupoil, V | 1 |
| Wolf, JE | 1 |
| David, M | 1 |
| Rochette, L | 1 |
| Euler, DE | 1 |
| Voogd, A | 2 |
| Sluiter, W | 2 |
| Koster, JF | 2 |
| Ustinova, EE | 2 |
| Schultz, HD | 2 |
| Watanabe, BI | 1 |
| Limm, W | 1 |
| Suehiro, A | 1 |
| Suehiro, G | 1 |
| Premaratne, S | 1 |
| McNamara, JJ | 1 |
| Pucheu, S | 1 |
| Coudray, C | 1 |
| Tresallet, N | 1 |
| Favier, A | 1 |
| de Leiris, J | 1 |
| Hedlund, BE | 1 |
| Hallaway, PE | 1 |
| Sekili, S | 1 |
| McCay, PB | 1 |
| Li, XY | 1 |
| Zughaib, M | 1 |
| Sun, JZ | 1 |
| Tang, L | 1 |
| Thornby, JI | 1 |
| Bolli, R | 1 |
| O'Neill, CA | 1 |
| Fu, LW | 1 |
| Halliwell, B | 1 |
| Shadid, M | 1 |
| Van Bel, F | 1 |
| Steendijk, P | 1 |
| Dorrepaal, CA | 1 |
| Moison, R | 1 |
| Van Der Velde, ET | 1 |
| Baan, J | 1 |
| Powell, SR | 1 |
| Gurzenda, EM | 1 |
| Wingertzahn, MA | 1 |
| Wapnir, RA | 1 |
| Karck, M | 1 |
| Tanaka, S | 1 |
| Berenshtein, E | 1 |
| Sturm, C | 1 |
| Haverich, A | 1 |
| Chevion, M | 1 |
| Sullivan, JL | 1 |
| van Eijk, HG | 1 |
1 review available for deferoxamine and Myocardial Ischemia
| Article | Year |
|---|---|
High-dose systemic iron chelation attenuates reperfusion injury.
Topics: Animals; Deferoxamine; Dogs; Iron; Iron Chelating Agents; Myocardial Ischemia; Myocardial Reperfusio | 1993 |
17 other studies available for deferoxamine and Myocardial Ischemia
| Article | Year |
|---|---|
Superparamagnetic iron oxide nanoparticles promote ferroptosis of ischemic cardiomyocytes.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Autophagy; Deferoxamine; Endopla | 2020 |
Ginsenoside Rg1 inhibits myocardial ischaemia and reperfusion injury
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Deferoxamine; Diabetes Mellitus, Experimental; Extracellul | 2019 |
Ischemia- and reperfusion-sensitive cardiac sympathetic afferents: influence of H2O2 and hydroxyl radicals.
Topics: Animals; Bradykinin; Cats; Deferoxamine; Female; Free Radical Scavengers; Heart Conduction System; H | 1995 |
Experimental preservation of the heart transplant: effects of deferoxamine on functional recovery and lipid peroxidation of the isolated-perfused rat heart subjected to ischemia and reperfusion.
Topics: Animals; Deferoxamine; Heart; In Vitro Techniques; Lipid Peroxidation; Male; Malondialdehyde; Myocar | 1995 |
Role of oxygen-derived free radicals in canine reperfusion arrhythmias.
Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Catalase; Coronary Circulation; Coronar | 1995 |
The increased susceptibility to hydrogen peroxide of the (post-)ischemic rat heart is associated with the magnitude of the low molecular weight iron pool.
Topics: Animals; Catalase; Deferoxamine; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Heart; | 1994 |
Activation of cardiac vagal afferents in ischemia and reperfusion. Prostaglandins versus oxygen-derived free radicals.
Topics: Afferent Pathways; Animals; Deferoxamine; Female; Heart; Hydrogen Peroxide; Indomethacin; Male; Myoc | 1994 |
Failure of deferoxamine to reduce myocardial infarct size in a primate model of ischemia-reperfusion injury.
Topics: Animals; Deferoxamine; Disease Models, Animal; Electrocardiography; Female; Free Radicals; Hydroxyl | 1993 |
Effect of iron overload in the isolated ischemic and reperfused rat heart.
Topics: Animals; Blood Pressure; Catalase; Deferoxamine; Female; Freezing; Glutathione Peroxidase; Heart Rat | 1993 |
Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial "stunning" in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects.
Topics: Animals; Coronary Circulation; Deferoxamine; Dogs; Female; Hemodynamics; Hydroxides; Hydroxyl Radica | 1993 |
Hydroxyl radical production during myocardial ischemia and reperfusion in cats.
Topics: Animals; Cats; Deferoxamine; Female; Free Radical Scavengers; Heart Ventricles; Hydroxyl Radical; La | 1996 |
Renal sympathetic nerve activity during cardiac ischemia and reperfusion in rats.
Topics: Administration, Topical; Animals; Blood Pressure; Capsaicin; Deferoxamine; Denervation; Heart Conduc | 1996 |
Effect of deferoxamine on post-hypoxic-ischemic reperfusion injury of the newborn lamb heart.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Chelating Agents; Deferoxamine; Dehydroascorbic Acid; Fema | 1999 |
Promotion of copper excretion from the isolated rat heart attenuates postischemic cardiac oxidative injury.
Topics: Animals; Antidotes; Chelating Agents; Copper; Deferoxamine; Histidine; Male; Myocardial Ischemia; My | 1999 |
The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection.
Topics: Analysis of Variance; Animals; Cardioplegic Solutions; Deferoxamine; Disease Models, Animal; Drug Sy | 2001 |
Stored iron and myocardial perfusion deficits.
Topics: Animals; Coronary Artery Disease; Deferoxamine; Ferritins; Humans; Hypercholesterolemia; Iron; Iron | 2002 |
Low molecular weight iron and the oxygen paradox in isolated rat hearts.
Topics: Animals; Deferoxamine; Free Radicals; Hypoxia; In Vitro Techniques; Iron; Male; Molecular Weight; My | 1992 |