Page last updated: 2024-10-25

deferoxamine and Multiple Sclerosis, Chronic Progressive

deferoxamine has been researched along with Multiple Sclerosis, Chronic Progressive in 1 studies

Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

Multiple Sclerosis, Chronic Progressive: A form of multiple sclerosis characterized by a progressive deterioration in neurologic function which is in contrast to the more typical relapsing remitting form. If the clinical course is free of distinct remissions, it is referred to as primary progressive multiple sclerosis. When the progressive decline is punctuated by acute exacerbations, it is referred to as progressive relapsing multiple sclerosis. The term secondary progressive multiple sclerosis is used when relapsing remitting multiple sclerosis evolves into the chronic progressive form. (From Ann Neurol 1994;36 Suppl:S73-S79; Adams et al., Principles of Neurology, 6th ed, pp903-914)

Research Excerpts

ExcerptRelevanceReference
" These results suggest that, while the drug is well tolerated, no effect on disease progression can be identified at this dosage level."2.69A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis. ( Fonseca, T; LeVine, SM; Lynch, SG, 2000)

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lynch, SG1
Fonseca, T1
LeVine, SM1

Trials

1 trial available for deferoxamine and Multiple Sclerosis, Chronic Progressive

ArticleYear
A multiple course trial of desferrioxamine in chronic progressive multiple sclerosis.
    Cellular and molecular biology (Noisy-le-Grand, France), 2000, Volume: 46, Issue:4

    Topics: Adult; Deferoxamine; Disease Progression; Female; Humans; Iron Chelating Agents; Magnetic Resonance

2000