deferoxamine has been researched along with Melanoma in 11 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Melanoma: A malignant neoplasm derived from cells that are capable of forming melanin, which may occur in the skin of any part of the body, in the eye, or, rarely, in the mucous membranes of the genitalia, anus, oral cavity, or other sites. It occurs mostly in adults and may originate de novo or from a pigmented nevus or malignant lentigo. Melanomas frequently metastasize widely, and the regional lymph nodes, liver, lungs, and brain are likely to be involved. The incidence of malignant skin melanomas is rising rapidly in all parts of the world. (Stedman, 25th ed; from Rook et al., Textbook of Dermatology, 4th ed, p2445)
| Excerpt | Relevance | Reference |
|---|---|---|
| "The mechanism of action of the clinically used iron(III) chelator, desferrioxamine (DFO), on preventing iron (Fe) uptake from transferrin (Tf) has been investigated using the human melanoma cell line SK-MEL-28." | 7.69 | The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell. ( Baker, E; Ponka, P; Richardson, D, 1994) |
| "The effect of ferric ammonium citrate (FAC) and desferrioxamine (DFO) on membrane iron and transferrin uptake have been investigated using SK-MEL-28 human melanoma cells which express the membrane-bound transferrin homologue, melanotransferrin, at high concentrations." | 7.68 | The effect of desferrioxamine and ferric ammonium citrate on the uptake of iron by the membrane iron-binding component of human melanoma cells. ( Baker, E; Richardson, DR, 1992) |
| "The effects of ferric ammonium citrate (FAC) and desferrioxamine (DFO) on iron (Fe), and transferrin (Tf) uptake have been investigated using SK-MEL-28 human melanoma cells, which express the Tf homologue, melanotransferrin, in high concentrations." | 7.68 | Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate. ( Baker, E; Richardson, D, 1992) |
| "The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations." | 7.68 | The release of iron and transferrin from the human melanoma cell. ( Baker, E; Richardson, DR, 1991) |
| "The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations." | 7.68 | The uptake of iron and transferrin by the human malignant melanoma cell. ( Baker, E; Richardson, DR, 1990) |
| "The mechanism of action of the clinically used iron(III) chelator, desferrioxamine (DFO), on preventing iron (Fe) uptake from transferrin (Tf) has been investigated using the human melanoma cell line SK-MEL-28." | 3.69 | The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell. ( Baker, E; Ponka, P; Richardson, D, 1994) |
| "The effect of ferric ammonium citrate (FAC) and desferrioxamine (DFO) on membrane iron and transferrin uptake have been investigated using SK-MEL-28 human melanoma cells which express the membrane-bound transferrin homologue, melanotransferrin, at high concentrations." | 3.68 | The effect of desferrioxamine and ferric ammonium citrate on the uptake of iron by the membrane iron-binding component of human melanoma cells. ( Baker, E; Richardson, DR, 1992) |
| "The effects of ferric ammonium citrate (FAC) and desferrioxamine (DFO) on iron (Fe), and transferrin (Tf) uptake have been investigated using SK-MEL-28 human melanoma cells, which express the Tf homologue, melanotransferrin, in high concentrations." | 3.68 | Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate. ( Baker, E; Richardson, D, 1992) |
| "The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations." | 3.68 | The release of iron and transferrin from the human melanoma cell. ( Baker, E; Richardson, DR, 1991) |
| "The human melanoma cell line, SK-MEL-28, expresses high levels of melanotransferrin." | 3.68 | The uptake of inorganic iron complexes by human melanoma cells. ( Baker, E; Richardson, D, 1991) |
| "The role of the transferrin homologue, melanotransferrin (p97), in iron metabolism has been studied using the human melanoma cell line, SK-MEL-28, which expresses this antigen in high concentrations." | 3.68 | The uptake of iron and transferrin by the human malignant melanoma cell. ( Baker, E; Richardson, DR, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 7 (63.64) | 18.2507 |
| 2000's | 1 (9.09) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, SA | 1 |
| Son, YO | 1 |
| Kook, SH | 1 |
| Choi, KC | 1 |
| Lee, JC | 1 |
| Ameri, K | 1 |
| Hammond, EM | 1 |
| Culmsee, C | 1 |
| Raida, M | 1 |
| Katschinski, DM | 1 |
| Wenger, RH | 1 |
| Wagner, E | 1 |
| Davis, RJ | 1 |
| Hai, T | 1 |
| Denko, N | 1 |
| Harris, AL | 1 |
| Iinuma, S | 1 |
| Farshi, SS | 1 |
| Ortel, B | 1 |
| Hasan, T | 1 |
| Richardson, D | 3 |
| Ponka, P | 1 |
| Baker, E | 6 |
| Hoffer, PB | 1 |
| Samuel, A | 1 |
| Bushberg, JT | 1 |
| Thakur, M | 1 |
| Richardson, DR | 3 |
| Hedley, D | 1 |
| Rugg, C | 1 |
| Musgrove, E | 1 |
| Taylor, I | 1 |
11 other studies available for deferoxamine and Melanoma
| Article | Year |
|---|---|
Ascorbic acid increases the activity and synthesis of tyrosinase in B16F10 cells through activation of p38 mitogen-activated protein kinase.
Topics: alpha-MSH; Animals; Anti-Inflammatory Agents, Non-Steroidal; Ascorbic Acid; Deferoxamine; Disease Mo | 2011 |
Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway.
Topics: Acetylcysteine; Activating Transcription Factor 3; Amino Acids, Dicarboxylic; Basic Helix-Loop-Helix | 2007 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; | 1994 |
The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell.
Topics: Cell Division; Cell Membrane; Cell Membrane Permeability; Deferoxamine; Ferric Compounds; Humans; Io | 1994 |
Desferoxamine mesylate (Desferal): a contrast-enhancing agent for gallium-37 imaging.
Topics: Abscess; Animals; Deferoxamine; Drug Interactions; Gallium Radioisotopes; Image Enhancement; Melanom | 1979 |
The effect of desferrioxamine and ferric ammonium citrate on the uptake of iron by the membrane iron-binding component of human melanoma cells.
Topics: Cell Membrane; Deferoxamine; Ferric Compounds; Humans; Iron; Melanoma; Quaternary Ammonium Compounds | 1992 |
Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate.
Topics: Biological Transport; Culture Media; Deferoxamine; Ferric Compounds; Humans; Iron; Kinetics; Melanom | 1992 |
The release of iron and transferrin from the human melanoma cell.
Topics: Antigens, Neoplasm; Cell Line; Deferoxamine; Humans; Iron; Iron Chelating Agents; Isoniazid; Kinetic | 1991 |
The uptake of inorganic iron complexes by human melanoma cells.
Topics: Ammonium Chloride; Antibodies, Monoclonal; Antigens, Neoplasm; Cell Membrane; Citrates; Citric Acid; | 1991 |
The uptake of iron and transferrin by the human malignant melanoma cell.
Topics: Antigens, Neoplasm; Binding Sites; Cell Membrane; Deferoxamine; Endocytosis; Humans; Iodine Radioiso | 1990 |
Modulation of transferrin receptor expression by inhibitors of nucleic acid synthesis.
Topics: Animals; Cell Line; Cell Survival; Deferoxamine; DNA Replication; Flow Cytometry; Fluorescence; Huma | 1985 |