deferoxamine has been researched along with Maple Syrup Urine Disease in 2 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Maple Syrup Urine Disease: An autosomal recessive inherited disorder with multiple forms of phenotypic expression, caused by a defect in the oxidative decarboxylation of branched-chain amino acids (AMINO ACIDS, BRANCHED-CHAIN). These metabolites accumulate in body fluids and render a maple syrup odor. The disease is divided into classic, intermediate, intermittent, and thiamine responsive subtypes. The classic form presents in the first week of life with ketoacidosis, hypoglycemia, emesis, neonatal seizures, and hypertonia. The intermediate and intermittent forms present in childhood or later with acute episodes of ataxia and vomiting. (From Adams et al., Principles of Neurology, 6th ed, p936)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Because the neurotoxic mechanisms of MSUD are poorly understood, this study aimed to evaluate the effects of chronic administration of a BCAA pool (leucine, isoleucine and valine)." | 1.39 | Chronic administration of branched-chain amino acids impairs spatial memory and increases brain-derived neurotrophic factor in a rat model. ( Bogo, MR; Comim, CM; Ferreira, GC; Gelain, DP; Moreira, JC; Oliveira, GM; Pasquali, MA; Quevedo, J; Scaini, G; Schuck, PF; Streck, EL, 2013) |
| " Here, we investigated whether acute and chronic administration of a BCAA pool causes impairment of acquisition and retention of avoidance memory in young rats." | 1.38 | Antioxidant administration prevents memory impairment in an animal model of maple syrup urine disease. ( Comim, CM; Dominguini, D; Ferreira, GC; Jeremias, IC; Mina, F; Morais, MO; Pescador, B; Quevedo, J; Scaini, G; Schuck, PF; Streck, EL; Teodorak, BP, 2012) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Scaini, G | 2 |
| Teodorak, BP | 1 |
| Jeremias, IC | 1 |
| Morais, MO | 1 |
| Mina, F | 1 |
| Dominguini, D | 1 |
| Pescador, B | 1 |
| Comim, CM | 2 |
| Schuck, PF | 2 |
| Ferreira, GC | 2 |
| Quevedo, J | 2 |
| Streck, EL | 2 |
| Oliveira, GM | 1 |
| Pasquali, MA | 1 |
| Gelain, DP | 1 |
| Moreira, JC | 1 |
| Bogo, MR | 1 |
2 other studies available for deferoxamine and Maple Syrup Urine Disease
| Article | Year |
|---|---|
Antioxidant administration prevents memory impairment in an animal model of maple syrup urine disease.
Topics: Acetylcysteine; Amino Acids, Branched-Chain; Animals; Antioxidants; Deferoxamine; Disease Models, An | 2012 |
Chronic administration of branched-chain amino acids impairs spatial memory and increases brain-derived neurotrophic factor in a rat model.
Topics: Acetylcysteine; Amino Acids, Branched-Chain; Animals; Antioxidants; Brain-Derived Neurotrophic Facto | 2013 |