deferoxamine has been researched along with Malaria in 26 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice." | 7.68 | Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R, 1992) |
| "The mechanism whereby deferoxamine (DF) inhibits the growth of malaria parasites was studied in rats infected with Plasmodium berghei." | 7.67 | Deferoxamine inhibition of malaria is independent of host iron status. ( Hershko, C; Peto, TE, 1988) |
| "Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity." | 6.69 | Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. ( Chantharaksri, U; Dangdoungjai, J; Looareesuiwan, S; Pipitaporn, B; Sibmooh, N; Udomsangpetch, R; Wilairatana, P, 2000) |
| "A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice." | 3.68 | Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R, 1992) |
| "The mechanism whereby deferoxamine (DF) inhibits the growth of malaria parasites was studied in rats infected with Plasmodium berghei." | 3.67 | Deferoxamine inhibition of malaria is independent of host iron status. ( Hershko, C; Peto, TE, 1988) |
| "Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity." | 2.69 | Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. ( Chantharaksri, U; Dangdoungjai, J; Looareesuiwan, S; Pipitaporn, B; Sibmooh, N; Udomsangpetch, R; Wilairatana, P, 2000) |
| "Parasitemia was reduced by all three treatment regimens; however, long-term survival was obtained only by treatment with liposomal DFO (days 7 and 8, 400 mg/kg/day)." | 1.30 | Plasmodium vinckei: optimization of desferrioxamine B delivery in the treatment of murine malaria. ( Eling, WM; Hermsen, CC; Postma, NS; Zuidema, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (38.46) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Obando, D | 1 |
| Liao, V | 1 |
| Lifa, T | 1 |
| Codd, R | 1 |
| Rodrigues, T | 1 |
| Prudêncio, M | 1 |
| Moreira, R | 1 |
| Mota, MM | 1 |
| Lopes, F | 1 |
| Isah, MB | 1 |
| Ibrahim, MA | 1 |
| Gordeuk, VR | 2 |
| Loyevsky, M | 1 |
| Ridley, RG | 1 |
| Omari, A | 1 |
| Garner, P | 1 |
| Huang, F | 1 |
| Tang, LH | 1 |
| Golenser, J | 1 |
| Domb, A | 1 |
| Mordechai-Daniel, T | 1 |
| Leshem, B | 1 |
| Luty, A | 1 |
| Kremsner, P | 1 |
| Pollack, S | 2 |
| Clark, IA | 4 |
| Cowden, WB | 3 |
| Hunt, NH | 3 |
| Maxwell, LE | 2 |
| Mackie, EJ | 2 |
| Hershko, C | 2 |
| Thuma, PE | 1 |
| Brittenham, GM | 1 |
| Postma, NS | 1 |
| Hermsen, CC | 1 |
| Zuidema, J | 1 |
| Eling, WM | 1 |
| Srivastava, PJ | 1 |
| Chandra, S | 2 |
| Arif, AJ | 2 |
| Singh, C | 2 |
| Panday, V | 1 |
| Sibmooh, N | 1 |
| Pipitaporn, B | 1 |
| Wilairatana, P | 1 |
| Dangdoungjai, J | 1 |
| Udomsangpetch, R | 1 |
| Looareesuiwan, S | 1 |
| Chantharaksri, U | 1 |
| Kremsner, PG | 1 |
| Neifer, S | 1 |
| Chaves, MF | 1 |
| Rudolph, R | 1 |
| Bienzle, U | 1 |
| Traore, O | 1 |
| Carnevale, P | 1 |
| Kaptue-Noche, L | 1 |
| M'Bede, J | 1 |
| Desfontaine, M | 1 |
| Elion, J | 1 |
| Labie, D | 1 |
| Nagel, RL | 1 |
| Lytton, SD | 1 |
| Cabantchik, ZI | 1 |
| Libman, J | 1 |
| Shanzer, A | 1 |
| Chaudhri, G | 1 |
| Stahel, E | 1 |
| Mazier, D | 1 |
| Guillouzo, A | 1 |
| Miltgen, F | 1 |
| Landau, I | 1 |
| Mellouk, S | 1 |
| Beaudoin, RL | 1 |
| Langlois, P | 1 |
| Gentilini, M | 1 |
| Peto, TE | 1 |
| Rossan, RN | 1 |
| Davidson, DE | 1 |
| Escajadillo, A | 1 |
| Mathur, PD | 1 |
| Sen, AB | 1 |
| Fritsch, G | 1 |
| Treumer, J | 1 |
| Spira, DT | 1 |
| Jung, A | 1 |
8 reviews available for deferoxamine and Malaria
| Article | Year |
|---|---|
The many faces of the adamantyl group in drug design.
Topics: Adamantane; Animals; Antimalarials; Diabetes Mellitus, Type 2; Drug Design; Humans; Hypoglycemic Age | 2011 |
Targeting the liver stage of malaria parasites: a yet unmet goal.
Topics: Animals; Antimalarials; Humans; Life Cycle Stages; Liver; Malaria; Plasmodium; Structure-Activity Re | 2012 |
The role of antioxidants treatment on the pathogenesis of malarial infections: a review.
Topics: Acetylcysteine; Antimalarials; Antioxidants; Ascorbic Acid; Deferoxamine; Folic Acid; Humans; Malari | 2014 |
Antimalarial effect of iron chelators.
Topics: Animals; Antimalarials; Child; Deferiprone; Deferoxamine; Drug Therapy, Combination; Humans; In Vitr | 2002 |
Malaria in endemic areas.
Topics: Antimalarials; Artemether; Artemisinins; Blood Transfusion; Chloroquine; Deferoxamine; Drug Combinat | 2003 |
[Research progress on iron chelator for malaria therapy].
Topics: Animals; Antimalarials; Deferoxamine; Humans; Iron Chelating Agents; Malaria; Razoxane | 2005 |
Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators.
Topics: Animals; Brain; Cell Division; Chelation Therapy; Deferoxamine; Graft Rejection; Heart; Humans; Iron | 1994 |
Iron chelation therapy for malaria.
Topics: Adult; Animals; Deferoxamine; Erythrocytes; Ferritins; Hemoglobins; Humans; Iron; Iron Chelating Age | 1994 |
2 trials available for deferoxamine and Malaria
| Article | Year |
|---|---|
Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Cyclic N-Oxides; Deferoxamine; Double-Blind Method | 2000 |
Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria.
Topics: Animals; Chloroquine; Deferoxamine; Drug Therapy, Combination; Humans; Malaria; Parasite Egg Count; | 1991 |
16 other studies available for deferoxamine and Malaria
| Article | Year |
|---|---|
Malaria: to kill a parasite.
Topics: Animals; Artemisinins; Calcium-Transporting ATPases; Deferoxamine; Iron; Iron Chelating Agents; Mala | 2003 |
Iron chelators: correlation between effects on Plasmodium spp. and immune functions.
Topics: Aldehydes; Animals; B-Lymphocytes; Cells, Cultured; Deferoxamine; Disease Models, Animal; Humans; Hy | 2006 |
Malaria and iron.
Topics: Deferoxamine; Female; Heme; Humans; Iron Deficiencies; Malaria; Plasmodium; Plasmodium falciparum; P | 1983 |
Activity of divicine in Plasmodium vinckei-infected mice has implications for treatment of favism and epidemiology of G-6-PD deficiency.
Topics: Animals; Deferoxamine; Erythrocytes; Favism; Female; Glucosephosphate Dehydrogenase Deficiency; Glut | 1984 |
Radical-mediated damage to parasites and erythrocytes in Plasmodium vinckei infected mice after injection of t-butyl hydroperoxide.
Topics: Animals; Deferoxamine; Erythrocytes; Female; Free Radicals; Glutathione; Hemolysis; Malaria; Male; M | 1984 |
Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria.
Topics: Alloxan; Animals; Deferoxamine; Erythrocytes; Female; Free Radicals; Hemolysis; Hydrogen Peroxide; M | 1983 |
Plasmodium vinckei: optimization of desferrioxamine B delivery in the treatment of murine malaria.
Topics: Animals; Deferoxamine; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Female; In | 1998 |
Metal chelators/antioxidants: approaches to protect erythrocytic oxidative stress injury during Plasmodium berghei infection in Mastomys coucha.
Topics: Animals; Antioxidants; Catechin; Chelating Agents; Deferoxamine; Erythrocytes; Glutathione; Lipid Pe | 1999 |
Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.
Topics: Animals; Arginine; Chloroquine; Deferoxamine; Female; Immunization; Interferon-gamma; Liver; Malaria | 1992 |
Reversed siderophores as antimalarial agents. II. Selective scavenging of Fe(III) from parasitized erythrocytes by a fluorescent derivative of desferal.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Antimalarials; Cell Membrane Permeability; Chelating Agents; | 1991 |
Possible roles for oxidants, through tumor necrosis factor, in malarial anemia.
Topics: Alloxan; Animals; Antioxidants; Cells, Cultured; Deferoxamine; Hydrogen Peroxide; Lipopolysaccharide | 1989 |
Iron chelators: in vitro inhibitory effect on the liver stage of rodent and human malaria.
Topics: Animals; Cells, Cultured; Deferoxamine; Dihydropyridines; Humans; Iron Chelating Agents; Liver; Mala | 1988 |
Deferoxamine inhibition of malaria is independent of host iron status.
Topics: Animals; Deferoxamine; Erythrocyte Indices; Erythrocytes; Female; Hematocrit; Hemoglobins; Iron; Iro | 1988 |
Desferrioxamine suppresses Plasmodium falciparum in Aotus monkeys.
Topics: Animals; Aotus trivirgatus; Deferoxamine; Malaria; Plasmodium falciparum | 1987 |
Effect of a specific iron chelator, desferrioxamine on the host biochemistry and parasitaemia in mice infected with Plasmodium berghei.
Topics: Aminopyrine N-Demethylase; Animals; Deferoxamine; Iron; Lipid Peroxides; Malaria; Male; Mice; Plasmo | 1985 |
Plasmodium vinckei: suppression of mouse infections with desferrioxamine B.
Topics: Animals; Deferoxamine; Malaria; Mice; Plasmodium; Time Factors | 1985 |