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deferoxamine and Malaria

deferoxamine has been researched along with Malaria in 26 studies

Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

Malaria: A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.

Research Excerpts

ExcerptRelevanceReference
"A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice."7.68Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R, 1992)
"The mechanism whereby deferoxamine (DF) inhibits the growth of malaria parasites was studied in rats infected with Plasmodium berghei."7.67Deferoxamine inhibition of malaria is independent of host iron status. ( Hershko, C; Peto, TE, 1988)
"Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity."6.69Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. ( Chantharaksri, U; Dangdoungjai, J; Looareesuiwan, S; Pipitaporn, B; Sibmooh, N; Udomsangpetch, R; Wilairatana, P, 2000)
"A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice."3.68Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R, 1992)
"The mechanism whereby deferoxamine (DF) inhibits the growth of malaria parasites was studied in rats infected with Plasmodium berghei."3.67Deferoxamine inhibition of malaria is independent of host iron status. ( Hershko, C; Peto, TE, 1988)
"Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity."2.69Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. ( Chantharaksri, U; Dangdoungjai, J; Looareesuiwan, S; Pipitaporn, B; Sibmooh, N; Udomsangpetch, R; Wilairatana, P, 2000)
"Parasitemia was reduced by all three treatment regimens; however, long-term survival was obtained only by treatment with liposomal DFO (days 7 and 8, 400 mg/kg/day)."1.30Plasmodium vinckei: optimization of desferrioxamine B delivery in the treatment of murine malaria. ( Eling, WM; Hermsen, CC; Postma, NS; Zuidema, J, 1998)

Research

Studies (26)

TimeframeStudies, this research(%)All Research%
pre-199010 (38.46)18.7374
1990's7 (26.92)18.2507
2000's6 (23.08)29.6817
2010's3 (11.54)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Liu, J1
Obando, D1
Liao, V1
Lifa, T1
Codd, R1
Rodrigues, T1
PrudĂȘncio, M1
Moreira, R1
Mota, MM1
Lopes, F1
Isah, MB1
Ibrahim, MA1
Gordeuk, VR2
Loyevsky, M1
Ridley, RG1
Omari, A1
Garner, P1
Huang, F1
Tang, LH1
Golenser, J1
Domb, A1
Mordechai-Daniel, T1
Leshem, B1
Luty, A1
Kremsner, P1
Pollack, S2
Clark, IA4
Cowden, WB3
Hunt, NH3
Maxwell, LE2
Mackie, EJ2
Hershko, C2
Thuma, PE1
Brittenham, GM1
Postma, NS1
Hermsen, CC1
Zuidema, J1
Eling, WM1
Srivastava, PJ1
Chandra, S2
Arif, AJ2
Singh, C2
Panday, V1
Sibmooh, N1
Pipitaporn, B1
Wilairatana, P1
Dangdoungjai, J1
Udomsangpetch, R1
Looareesuiwan, S1
Chantharaksri, U1
Kremsner, PG1
Neifer, S1
Chaves, MF1
Rudolph, R1
Bienzle, U1
Traore, O1
Carnevale, P1
Kaptue-Noche, L1
M'Bede, J1
Desfontaine, M1
Elion, J1
Labie, D1
Nagel, RL1
Lytton, SD1
Cabantchik, ZI1
Libman, J1
Shanzer, A1
Chaudhri, G1
Stahel, E1
Mazier, D1
Guillouzo, A1
Miltgen, F1
Landau, I1
Mellouk, S1
Beaudoin, RL1
Langlois, P1
Gentilini, M1
Peto, TE1
Rossan, RN1
Davidson, DE1
Escajadillo, A1
Mathur, PD1
Sen, AB1
Fritsch, G1
Treumer, J1
Spira, DT1
Jung, A1

Reviews

8 reviews available for deferoxamine and Malaria

ArticleYear
The many faces of the adamantyl group in drug design.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:6

    Topics: Adamantane; Animals; Antimalarials; Diabetes Mellitus, Type 2; Drug Design; Humans; Hypoglycemic Age

2011
Targeting the liver stage of malaria parasites: a yet unmet goal.
    Journal of medicinal chemistry, 2012, Feb-09, Volume: 55, Issue:3

    Topics: Animals; Antimalarials; Humans; Life Cycle Stages; Liver; Malaria; Plasmodium; Structure-Activity Re

2012
The role of antioxidants treatment on the pathogenesis of malarial infections: a review.
    Parasitology research, 2014, Volume: 113, Issue:3

    Topics: Acetylcysteine; Antimalarials; Antioxidants; Ascorbic Acid; Deferoxamine; Folic Acid; Humans; Malari

2014
Antimalarial effect of iron chelators.
    Advances in experimental medicine and biology, 2002, Volume: 509

    Topics: Animals; Antimalarials; Child; Deferiprone; Deferoxamine; Drug Therapy, Combination; Humans; In Vitr

2002
Malaria in endemic areas.
    Clinical evidence, 2003, Issue:9

    Topics: Antimalarials; Artemether; Artemisinins; Blood Transfusion; Chloroquine; Deferoxamine; Drug Combinat

2003
[Research progress on iron chelator for malaria therapy].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 2005, Aug-30, Volume: 23, Issue:4

    Topics: Animals; Antimalarials; Deferoxamine; Humans; Iron Chelating Agents; Malaria; Razoxane

2005
Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators.
    Bailliere's clinical haematology, 1994, Volume: 7, Issue:4

    Topics: Animals; Brain; Cell Division; Chelation Therapy; Deferoxamine; Graft Rejection; Heart; Humans; Iron

1994
Iron chelation therapy for malaria.
    Advances in experimental medicine and biology, 1994, Volume: 356

    Topics: Adult; Animals; Deferoxamine; Erythrocytes; Ferritins; Hemoglobins; Humans; Iron; Iron Chelating Age

1994

Trials

2 trials available for deferoxamine and Malaria

ArticleYear
Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria.
    Biological & pharmaceutical bulletin, 2000, Volume: 23, Issue:11

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; Cyclic N-Oxides; Deferoxamine; Double-Blind Method

2000
Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria.
    American journal of hematology, 1991, Volume: 37, Issue:3

    Topics: Animals; Chloroquine; Deferoxamine; Drug Therapy, Combination; Humans; Malaria; Parasite Egg Count;

1991

Other Studies

16 other studies available for deferoxamine and Malaria

ArticleYear
Malaria: to kill a parasite.
    Nature, 2003, Aug-21, Volume: 424, Issue:6951

    Topics: Animals; Artemisinins; Calcium-Transporting ATPases; Deferoxamine; Iron; Iron Chelating Agents; Mala

2003
Iron chelators: correlation between effects on Plasmodium spp. and immune functions.
    The Journal of parasitology, 2006, Volume: 92, Issue:1

    Topics: Aldehydes; Animals; B-Lymphocytes; Cells, Cultured; Deferoxamine; Disease Models, Animal; Humans; Hy

2006
Malaria and iron.
    British journal of haematology, 1983, Volume: 53, Issue:2

    Topics: Deferoxamine; Female; Heme; Humans; Iron Deficiencies; Malaria; Plasmodium; Plasmodium falciparum; P

1983
Activity of divicine in Plasmodium vinckei-infected mice has implications for treatment of favism and epidemiology of G-6-PD deficiency.
    British journal of haematology, 1984, Volume: 57, Issue:3

    Topics: Animals; Deferoxamine; Erythrocytes; Favism; Female; Glucosephosphate Dehydrogenase Deficiency; Glut

1984
Radical-mediated damage to parasites and erythrocytes in Plasmodium vinckei infected mice after injection of t-butyl hydroperoxide.
    Clinical and experimental immunology, 1984, Volume: 56, Issue:3

    Topics: Animals; Deferoxamine; Erythrocytes; Female; Free Radicals; Glutathione; Hemolysis; Malaria; Male; M

1984
Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria.
    Infection and immunity, 1983, Volume: 39, Issue:1

    Topics: Alloxan; Animals; Deferoxamine; Erythrocytes; Female; Free Radicals; Hemolysis; Hydrogen Peroxide; M

1983
Plasmodium vinckei: optimization of desferrioxamine B delivery in the treatment of murine malaria.
    Experimental parasitology, 1998, Volume: 89, Issue:3

    Topics: Animals; Deferoxamine; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Female; In

1998
Metal chelators/antioxidants: approaches to protect erythrocytic oxidative stress injury during Plasmodium berghei infection in Mastomys coucha.
    Pharmacological research, 1999, Volume: 40, Issue:3

    Topics: Animals; Antioxidants; Catechin; Chelating Agents; Deferoxamine; Erythrocytes; Glutathione; Lipid Pe

1999
Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.
    European journal of immunology, 1992, Volume: 22, Issue:11

    Topics: Animals; Arginine; Chloroquine; Deferoxamine; Female; Immunization; Interferon-gamma; Liver; Malaria

1992
Reversed siderophores as antimalarial agents. II. Selective scavenging of Fe(III) from parasitized erythrocytes by a fluorescent derivative of desferal.
    Molecular pharmacology, 1991, Volume: 40, Issue:4

    Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Antimalarials; Cell Membrane Permeability; Chelating Agents;

1991
Possible roles for oxidants, through tumor necrosis factor, in malarial anemia.
    Progress in clinical and biological research, 1989, Volume: 313

    Topics: Alloxan; Animals; Antioxidants; Cells, Cultured; Deferoxamine; Hydrogen Peroxide; Lipopolysaccharide

1989
Iron chelators: in vitro inhibitory effect on the liver stage of rodent and human malaria.
    The American journal of tropical medicine and hygiene, 1988, Volume: 39, Issue:3

    Topics: Animals; Cells, Cultured; Deferoxamine; Dihydropyridines; Humans; Iron Chelating Agents; Liver; Mala

1988
Deferoxamine inhibition of malaria is independent of host iron status.
    The Journal of experimental medicine, 1988, Jul-01, Volume: 168, Issue:1

    Topics: Animals; Deferoxamine; Erythrocyte Indices; Erythrocytes; Female; Hematocrit; Hemoglobins; Iron; Iro

1988
Desferrioxamine suppresses Plasmodium falciparum in Aotus monkeys.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1987, Volume: 184, Issue:2

    Topics: Animals; Aotus trivirgatus; Deferoxamine; Malaria; Plasmodium falciparum

1987
Effect of a specific iron chelator, desferrioxamine on the host biochemistry and parasitaemia in mice infected with Plasmodium berghei.
    Indian journal of malariology, 1985, Volume: 22, Issue:1

    Topics: Aminopyrine N-Demethylase; Animals; Deferoxamine; Iron; Lipid Peroxides; Malaria; Male; Mice; Plasmo

1985
Plasmodium vinckei: suppression of mouse infections with desferrioxamine B.
    Experimental parasitology, 1985, Volume: 60, Issue:2

    Topics: Animals; Deferoxamine; Malaria; Mice; Plasmodium; Time Factors

1985