deferoxamine has been researched along with Liver Failure, Acute in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Liver Failure, Acute: A form of rapid-onset LIVER FAILURE, also known as fulminant hepatic failure, caused by severe liver injury or massive loss of HEPATOCYTES. It is characterized by sudden development of liver dysfunction and JAUNDICE. Acute liver failure may progress to exhibit cerebral dysfunction even HEPATIC COMA depending on the etiology that includes hepatic ISCHEMIA, drug toxicity, malignant infiltration, and viral hepatitis such as post-transfusion HEPATITIS B and HEPATITIS C.
| Excerpt | Relevance | Reference |
|---|---|---|
| "N-acetylcysteine plus deferoxamine treatment significantly attenuated hepatic and central nervous system oxidative damage after acute hepatic failure induced by CCl4." | 7.72 | Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. ( Andrades, M; Dal-Pizzol, F; Martins, MR; Menna-Barreto, S; Moreira, JC; Quevedo, J; Reinke, A; Ritter, C; Rocha, J, 2004) |
| "N-acetylcysteine plus deferoxamine treatment significantly attenuated hepatic and central nervous system oxidative damage after acute hepatic failure induced by CCl4." | 3.72 | Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats. ( Andrades, M; Dal-Pizzol, F; Martins, MR; Menna-Barreto, S; Moreira, JC; Quevedo, J; Reinke, A; Ritter, C; Rocha, J, 2004) |
| "Treatment with deferoxamine was prompt and followed by empiric N-acetylcysteine once liver injury was apparent." | 1.33 | Acute liver failure due to iron overdose in an adult. ( Daram, SR; Hayashi, PH, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (83.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yamada, N | 1 |
| Karasawa, T | 1 |
| Kimura, H | 1 |
| Watanabe, S | 1 |
| Komada, T | 1 |
| Kamata, R | 1 |
| Sampilvanjil, A | 1 |
| Ito, J | 1 |
| Nakagawa, K | 1 |
| Kuwata, H | 1 |
| Hara, S | 1 |
| Mizuta, K | 1 |
| Sakuma, Y | 1 |
| Sata, N | 1 |
| Takahashi, M | 1 |
| Arkadopoulos, N | 1 |
| Vlahakos, D | 2 |
| Kostopanagiotou, G | 1 |
| Panagopoulos, D | 2 |
| Karvouni, E | 1 |
| Routsi, C | 2 |
| Kalimeris, K | 1 |
| Andreadou, I | 1 |
| Kouskouni, E | 1 |
| Smyrniotis, V | 2 |
| Kostopanagiotou, GG | 1 |
| Kalimeris, KA | 1 |
| Arkadopoulos, NP | 1 |
| Pafiti, A | 1 |
| Lekka, ME | 1 |
| Nakos, G | 1 |
| Ritter, C | 1 |
| Reinke, A | 1 |
| Andrades, M | 1 |
| Martins, MR | 1 |
| Rocha, J | 1 |
| Menna-Barreto, S | 1 |
| Quevedo, J | 1 |
| Moreira, JC | 1 |
| Dal-Pizzol, F | 1 |
| Daram, SR | 1 |
| Hayashi, PH | 1 |
| Venkat-Raman, N | 1 |
| Venkata-Krishnan, RV | 1 |
| Howarth, ES | 1 |
6 other studies available for deferoxamine and Liver Failure, Acute
| Article | Year |
|---|---|
Ferroptosis driven by radical oxidation of n-6 polyunsaturated fatty acids mediates acetaminophen-induced acute liver failure.
Topics: Acetaminophen; alpha-Tocopherol; Animals; Antioxidants; Coenzyme A Ligases; Cyclohexylamines; Cycloo | 2020 |
Iron chelation attenuates intracranial pressure and improves survival in a swine model of acute liver failure.
Topics: Animals; Brain; Central Venous Pressure; Cytokines; Deferoxamine; Disease Models, Animal; Female; In | 2008 |
Desferrioxamine attenuates minor lung injury following surgical acute liver failure.
Topics: Acute Lung Injury; Analysis of Variance; Animals; Bronchoalveolar Lavage Fluid; Catalase; Deferoxami | 2009 |
Protective effect of N-acetylcysteine and deferoxamine on carbon tetrachloride-induced acute hepatic failure in rats.
Topics: Acetylcysteine; Animals; Antioxidants; Carbon Tetrachloride; Deferoxamine; Hydrocarbons; Inflammatio | 2004 |
Acute liver failure due to iron overdose in an adult.
Topics: Adolescent; Alanine Transaminase; Deferoxamine; Drug Overdose; Female; Humans; Iron; Iron Chelating | 2005 |
Successful pregnancy outcome following maternal intravenous immunoglobulin treatment in a woman with recurrent perinatal haemochromatosis.
Topics: Acetylcysteine; Adult; Deferoxamine; Diagnosis, Differential; Female; Ferritins; Fetal Diseases; Fre | 2006 |