deferoxamine has been researched along with Leukemia in 20 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Leukemia: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
| Excerpt | Relevance | Reference |
|---|---|---|
| "BACKGROUND This study aimed to investigate the effect of deferoxamine (DFO) on leukemia in vitro, and to explore the underlying molecular mechanism." | 7.88 | Effects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism. ( Su, A; Xu, Y; Yang, D; Yang, Y; Zhang, X, 2018) |
| "BACKGROUND This study aimed to investigate the effect of deferoxamine (DFO) on leukemia in vitro, and to explore the underlying molecular mechanism." | 3.88 | Effects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism. ( Su, A; Xu, Y; Yang, D; Yang, Y; Zhang, X, 2018) |
| "The aim of this study is to investigate the growth-inhibitory and apoptosis-inducing effect of deferoxamine (DFO) combined with arsenic trioxide (ATO) on the human HL-60 xenografts in nude mice and its mechanism." | 1.40 | The growth-inhibitory and apoptosis-inducing effect of deferoxamine combined with arsenic trioxide on HL-60 xenografts in nude mice. ( Liu, Y; Ren, X; Wang, D; Yu, R; Zeng, L, 2014) |
| "Etoposide (VP-16) is an antitumor drug currently in use for the treatment of a number of human cancers." | 1.29 | Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates. ( Gantchev, T; Kagan, V; Stoyanovsky, D; Yalowich, J, 1993) |
| "Deferoxamine is a hydroxylamine which binds ferric ions to form a highly stable complex." | 1.27 | Inhibition of proliferation of human leukaemic cell populations by deferoxamine. ( Foa, P; Lombardi, L; Maiolo, AT; Polli, EE; Villa, L, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Xu, Y | 1 |
| Su, A | 1 |
| Yang, D | 1 |
| Zhang, X | 1 |
| Itkonen, O | 1 |
| Vaahtera, L | 1 |
| Parkkinen, J | 1 |
| Yu, R | 1 |
| Wang, D | 1 |
| Ren, X | 1 |
| Zeng, L | 1 |
| Liu, Y | 1 |
| Diamantidis, MD | 1 |
| Papaioannou, M | 1 |
| WALSH, JR | 1 |
| MASS, RE | 1 |
| SMITH, FW | 1 |
| LANGE, V | 1 |
| WILKINSON, JF | 1 |
| Xue, ZH | 1 |
| Jiang, Y | 2 |
| Yu, Y | 2 |
| Wang, LS | 1 |
| Chen, GQ | 2 |
| Zhao, Q | 1 |
| Guo, M | 1 |
| Song, LP | 1 |
| Liu, W | 1 |
| Gambari, R | 1 |
| Raschellà, G | 1 |
| Tripodi, M | 1 |
| Farace, MG | 1 |
| Fantoni, A | 1 |
| Stoyanovsky, D | 1 |
| Yalowich, J | 1 |
| Gantchev, T | 1 |
| Kagan, V | 1 |
| Hrubá, A | 1 |
| Skala, JP | 1 |
| Matĕjcková, S | 1 |
| Fales, I | 1 |
| Vodvárková, S | 1 |
| Starý, J | 1 |
| Kavan, P | 1 |
| Kobylka, P | 1 |
| Chiou, TJ | 1 |
| Chou, YT | 1 |
| Tzeng, WF | 1 |
| Caraglia, M | 1 |
| Tagliaferri, P | 1 |
| Budillon, A | 1 |
| Abbruzzese, A | 1 |
| Abe, Y | 1 |
| Muta, K | 1 |
| Nishimura, J | 1 |
| Nawata, H | 1 |
| Cazzola, M | 1 |
| Bergamaschi, G | 1 |
| Dezza, L | 1 |
| Ponchio, L | 1 |
| Rosti, V | 1 |
| Zappone, E | 1 |
| Ascari, E | 1 |
| Hedley, D | 1 |
| Rugg, C | 1 |
| Musgrove, E | 1 |
| Taylor, I | 1 |
| Kodama, M | 1 |
| Hanada, S | 1 |
| Kuwazuru, Y | 1 |
| Saito, T | 1 |
| Uozumi, K | 1 |
| Makino, T | 1 |
| Terada, A | 1 |
| Hashimoto, S | 1 |
| Tomoyasu, S | 1 |
| Nakamaki, T | 1 |
| Suzuki, K | 1 |
| Tsuruoka, N | 1 |
| Foa, P | 1 |
| Maiolo, AT | 1 |
| Lombardi, L | 1 |
| Villa, L | 1 |
| Polli, EE | 1 |
| Singh, AK | 1 |
2 reviews available for deferoxamine and Leukemia
| Article | Year |
|---|---|
ADVANCES IN TREATMENT OF DISEASES OF THE BLOOD.
Topics: Anemia; Anemia, Aplastic; Anemia, Pernicious; Bone Marrow Transplantation; Deferoxamine; Drug Therap | 1964 |
Role of iron and proteins of iron metabolism in cell growth. Potential for manipulations of cellular iron metabolism in modulating cell proliferation.
Topics: Animals; Antibodies, Monoclonal; Cell Cycle; Cell Division; Deferoxamine; Epitopes; Ferritins; Hemat | 1991 |
18 other studies available for deferoxamine and Leukemia
| Article | Year |
|---|---|
Effects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism.
Topics: A549 Cells; Apoptosis; Cell Survival; Deferoxamine; Humans; Iron; K562 Cells; Leukemia | 2018 |
Comparison of bleomycin-detectable iron and labile plasma iron assays.
Topics: Bleomycin; Deferoxamine; Hematopoietic Stem Cell Transplantation; Humans; Indicators and Reagents; I | 2013 |
The growth-inhibitory and apoptosis-inducing effect of deferoxamine combined with arsenic trioxide on HL-60 xenografts in nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Ce | 2014 |
Toward adjunctive therapy of acute myeloid leukemia: is it feasible?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Ce | 2014 |
DESFERRIOXAMINE EFFECT ON IRON EXCRETION IN HEMOCHROMATOSIS.
Topics: Deferoxamine; Hemochromatosis; Hemosiderosis; Humans; Iron; Iron Chelating Agents; Iron Isotopes; Le | 1964 |
Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1alpha protein.
Topics: Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cell Line, T | 2005 |
Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms.
Topics: Base Sequence; Caspase 3; Caspase 8; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; DNA Prime | 2006 |
Desferrioxamine inhibits induced erythroid differentiation of human leukemic K-562 cells.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Cell Division; Deferoxamine; Erythroblasts; Erythrocy | 1983 |
Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates.
Topics: Ascorbic Acid; Cell Nucleus; Chromatography, High Pressure Liquid; Deferoxamine; Electron Spin Reson | 1993 |
[Purging of hemopoietic progenitor cells in autologous transplantation].
Topics: Adult; Bone Marrow Purging; Child; Cyclophosphamide; Deferoxamine; Etoposide; Hematopoietic Stem Cel | 1997 |
Menadione-induced cell degeneration is related to lipid peroxidation in human cancer cells.
Topics: Calcium; Carcinoma, Hepatocellular; Cell Death; Chelating Agents; Deferoxamine; Dicumarol; Glutathio | 1998 |
Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anti-cancer therapy.
Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Chelating Agents; Cytarabine; Deferoxamine; Epidermal | 1999 |
Regulation of transferrin receptors by iron in human erythroblasts.
Topics: Blotting, Northern; Deferoxamine; DNA; Endocytosis; Erythroblasts; Hemin; Humans; Iron; Leukemia; Ly | 1992 |
Modulation of transferrin receptor expression by inhibitors of nucleic acid synthesis.
Topics: Animals; Cell Line; Cell Survival; Deferoxamine; DNA Replication; Flow Cytometry; Fluorescence; Huma | 1985 |
[Inhibitory effect of deferoxamine on DNA synthesis in the lymphoid cell lines].
Topics: Deferoxamine; DNA, Neoplasm; Humans; Leukemia; Tumor Cells, Cultured | 1988 |
[Growth inhibition and promotion of differentiation induction in cultured leukemia cell lines by deferoxamine].
Topics: Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Deferoxamine; Humans; L | 1987 |
Inhibition of proliferation of human leukaemic cell populations by deferoxamine.
Topics: Cell Division; Cell Line; Deferoxamine; DNA; Humans; Interphase; Leukemia; Leukemia, Lymphoid; Leuke | 1986 |
A comparison of desferrioxamine-induced sideruria and measurement of labile iron store as indices of body iron status.
Topics: Adult; Anemia, Hypochromic; Anemia, Macrocytic; Autoanalysis; Body Composition; Chelating Agents; De | 1971 |