deferoxamine has been researched along with Leukemia L 1210 in 14 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Deoxyguanosine or deoxyadenosine combined with HAG-IQ inhibited cell growth in an additive manner; three-drug combinations, HAG-IQ plus either deoxyguanosine/8-aminoguanosine or deoxyadenosine/deoxycoformycin, were strongly synergistic." | 1.27 | Effects of N-hydroxy-N'-aminoguanidine isoquinoline in combination with other inhibitors of ribonucleotide reductase on L1210 cells. ( Cory, JG; Lien, EJ; Weckbecker, A; Weckbecker, G, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (57.14) | 18.7374 |
| 1990's | 5 (35.71) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lee, DH | 1 |
| Jang, PS | 1 |
| Chung, NG | 1 |
| Cho, B | 1 |
| Jeong, DC | 1 |
| Kim, HK | 1 |
| Sato, A | 4 |
| Bacon, PE | 3 |
| Cory, JG | 6 |
| Carter, GL | 2 |
| Montgomery, JA | 1 |
| Cory, AH | 1 |
| Rappa, G | 1 |
| Lorico, A | 1 |
| Liu, MC | 1 |
| Lin, TS | 1 |
| Sartorelli, AC | 1 |
| Lin, F | 3 |
| Girotti, AW | 4 |
| Geiger, PG | 2 |
| Korytowski, W | 1 |
| Thomas, JP | 1 |
| Weckbecker, G | 1 |
| Weckbecker, A | 1 |
| Lien, EJ | 1 |
| Bergeron, RJ | 1 |
| Ingeno, MJ | 1 |
| Basset, P | 1 |
| Quesneau, Y | 1 |
| Zwiller, J | 1 |
| Brockman, RW | 1 |
1 review available for deferoxamine and Leukemia L 1210
| Article | Year |
|---|---|
Biochemical aspects of drug combinations.
Topics: Alkylating Agents; Animals; Antineoplastic Agents; Bleomycin; Camptothecin; Cell Division; Cytarabin | 1974 |
13 other studies available for deferoxamine and Leukemia L 1210
| Article | Year |
|---|---|
Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status.
Topics: Animals; Antineoplastic Agents; Apoptosis; Benzoates; Cell Line, Tumor; Chlorides; Crosses, Genetic; | 2013 |
Studies on the differential mechanisms of inhibition of ribonucleotide reductase by specific inhibitors of the non-heme iron subunit.
Topics: Anaerobiosis; Animals; Catalase; Cell Division; Cells, Cultured; Deferoxamine; Guanazole; Humans; Hy | 1984 |
Effects of biochemical modulation of drug combinations directed at the ribonucleotide reductase site on leukemia L1210 cell growth in culture.
Topics: Adenine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cells, Cultured; De | 1983 |
Synergistic inhibition of leukemia L1210 cell growth in vitro by combinations of 2-fluoroadenine nucleosides and hydroxyurea or 2,3-dihydro-1H-pyrazole[2,3-a]imidazole.
Topics: Animals; Cell Survival; Cytidine; Deferoxamine; Deoxyadenosines; Deoxycytidine; Drug Synergism; Hydr | 1984 |
Effects of combinations of drugs having different modes of action at the ribonucleotide reductase site on growth of L1210 cells in culture.
Topics: Adenine; Animals; Antineoplastic Agents; Deferoxamine; Deoxyadenosines; Hydroxyurea; Kinetics; Leuke | 1982 |
Structure-function relationships for a new series of pyridine-2-carboxaldehyde thiosemicarbazones on ribonucleotide reductase activity and tumor cell growth in culture and in vivo.
Topics: Acetylation; Animals; Antineoplastic Agents; Cell Division; Cytidine; Deferoxamine; DNA; Ferric Comp | 1995 |
Photodynamic action of merocyanine 540 on leukemia cells: iron-stimulated lipid peroxidation and cell killing.
Topics: Animals; Cell Survival; Clone Cells; Deferoxamine; Dose-Response Relationship, Drug; Dose-Response R | 1993 |
Hyperresistance of leukemia cells to photodynamic inactivation after long-term exposure to hemin.
Topics: Animals; Antidotes; Apoferritins; Cell Survival; Deferoxamine; Drug Resistance; Enzyme Induction; Fe | 1996 |
Lipid peroxidation in photodynamically stressed mammalian cells: use of cholesterol hydroperoxides as mechanistic reporters.
Topics: Animals; Butylated Hydroxytoluene; Cell Survival; Cholesterol; Chromatography, High Pressure Liquid; | 1997 |
Lethal damage to murine L1210 cells by exogenous lipid hydroperoxides: protective role of glutathione-dependent selenoperoxidases.
Topics: Animals; Butylated Hydroxytoluene; Cell Survival; Cell-Free System; Cholesterol; Deferoxamine; Dose- | 1991 |
Effects of N-hydroxy-N'-aminoguanidine isoquinoline in combination with other inhibitors of ribonucleotide reductase on L1210 cells.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Deferoxamine; Deoxyguanosine | 1988 |
Microbial iron chelator-induced cell cycle synchronization in L1210 cells: potential in combination chemotherapy.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Cycle; Cell Division; Cell Survival; D | 1987 |
Iron-induced L1210 cell growth: evidence of a transferrin-independent iron transport.
Topics: Animals; Biological Transport; Cell Survival; Cells, Cultured; Deferoxamine; DNA; Iron; Leukemia L12 | 1986 |