deferoxamine has been researched along with Leucocythaemia in 20 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "BACKGROUND This study aimed to investigate the effect of deferoxamine (DFO) on leukemia in vitro, and to explore the underlying molecular mechanism." | 7.88 | Effects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism. ( Su, A; Xu, Y; Yang, D; Yang, Y; Zhang, X, 2018) |
| "BACKGROUND This study aimed to investigate the effect of deferoxamine (DFO) on leukemia in vitro, and to explore the underlying molecular mechanism." | 3.88 | Effects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism. ( Su, A; Xu, Y; Yang, D; Yang, Y; Zhang, X, 2018) |
| "The aim of this study is to investigate the growth-inhibitory and apoptosis-inducing effect of deferoxamine (DFO) combined with arsenic trioxide (ATO) on the human HL-60 xenografts in nude mice and its mechanism." | 1.40 | The growth-inhibitory and apoptosis-inducing effect of deferoxamine combined with arsenic trioxide on HL-60 xenografts in nude mice. ( Liu, Y; Ren, X; Wang, D; Yu, R; Zeng, L, 2014) |
| "Etoposide (VP-16) is an antitumor drug currently in use for the treatment of a number of human cancers." | 1.29 | Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates. ( Gantchev, T; Kagan, V; Stoyanovsky, D; Yalowich, J, 1993) |
| "Deferoxamine is a hydroxylamine which binds ferric ions to form a highly stable complex." | 1.27 | Inhibition of proliferation of human leukaemic cell populations by deferoxamine. ( Foa, P; Lombardi, L; Maiolo, AT; Polli, EE; Villa, L, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (40.00) | 18.7374 |
| 1990's | 6 (30.00) | 18.2507 |
| 2000's | 2 (10.00) | 29.6817 |
| 2010's | 4 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Yang, Y | 1 |
| Xu, Y | 1 |
| Su, A | 1 |
| Yang, D | 1 |
| Zhang, X | 1 |
| Itkonen, O | 1 |
| Vaahtera, L | 1 |
| Parkkinen, J | 1 |
| Yu, R | 1 |
| Wang, D | 1 |
| Ren, X | 1 |
| Zeng, L | 1 |
| Liu, Y | 1 |
| Diamantidis, MD | 1 |
| Papaioannou, M | 1 |
| WALSH, JR | 1 |
| MASS, RE | 1 |
| SMITH, FW | 1 |
| LANGE, V | 1 |
| WILKINSON, JF | 1 |
| Xue, ZH | 1 |
| Jiang, Y | 2 |
| Yu, Y | 2 |
| Wang, LS | 1 |
| Chen, GQ | 2 |
| Zhao, Q | 1 |
| Guo, M | 1 |
| Song, LP | 1 |
| Liu, W | 1 |
| Gambari, R | 1 |
| Raschellà, G | 1 |
| Tripodi, M | 1 |
| Farace, MG | 1 |
| Fantoni, A | 1 |
| Stoyanovsky, D | 1 |
| Yalowich, J | 1 |
| Gantchev, T | 1 |
| Kagan, V | 1 |
| Hrubá, A | 1 |
| Skala, JP | 1 |
| Matĕjcková, S | 1 |
| Fales, I | 1 |
| Vodvárková, S | 1 |
| Starý, J | 1 |
| Kavan, P | 1 |
| Kobylka, P | 1 |
| Chiou, TJ | 1 |
| Chou, YT | 1 |
| Tzeng, WF | 1 |
| Caraglia, M | 1 |
| Tagliaferri, P | 1 |
| Budillon, A | 1 |
| Abbruzzese, A | 1 |
| Abe, Y | 1 |
| Muta, K | 1 |
| Nishimura, J | 1 |
| Nawata, H | 1 |
| Cazzola, M | 1 |
| Bergamaschi, G | 1 |
| Dezza, L | 1 |
| Ponchio, L | 1 |
| Rosti, V | 1 |
| Zappone, E | 1 |
| Ascari, E | 1 |
| Hedley, D | 1 |
| Rugg, C | 1 |
| Musgrove, E | 1 |
| Taylor, I | 1 |
| Kodama, M | 1 |
| Hanada, S | 1 |
| Kuwazuru, Y | 1 |
| Saito, T | 1 |
| Uozumi, K | 1 |
| Makino, T | 1 |
| Terada, A | 1 |
| Hashimoto, S | 1 |
| Tomoyasu, S | 1 |
| Nakamaki, T | 1 |
| Suzuki, K | 1 |
| Tsuruoka, N | 1 |
| Foa, P | 1 |
| Maiolo, AT | 1 |
| Lombardi, L | 1 |
| Villa, L | 1 |
| Polli, EE | 1 |
| Singh, AK | 1 |
2 reviews available for deferoxamine and Leucocythaemia
| Article | Year |
|---|---|
ADVANCES IN TREATMENT OF DISEASES OF THE BLOOD.
Topics: Anemia; Anemia, Aplastic; Anemia, Pernicious; Bone Marrow Transplantation; Deferoxamine; Drug Therap | 1964 |
Role of iron and proteins of iron metabolism in cell growth. Potential for manipulations of cellular iron metabolism in modulating cell proliferation.
Topics: Animals; Antibodies, Monoclonal; Cell Cycle; Cell Division; Deferoxamine; Epitopes; Ferritins; Hemat | 1991 |
18 other studies available for deferoxamine and Leucocythaemia
| Article | Year |
|---|---|
Effects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism.
Topics: A549 Cells; Apoptosis; Cell Survival; Deferoxamine; Humans; Iron; K562 Cells; Leukemia | 2018 |
Comparison of bleomycin-detectable iron and labile plasma iron assays.
Topics: Bleomycin; Deferoxamine; Hematopoietic Stem Cell Transplantation; Humans; Indicators and Reagents; I | 2013 |
The growth-inhibitory and apoptosis-inducing effect of deferoxamine combined with arsenic trioxide on HL-60 xenografts in nude mice.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Ce | 2014 |
Toward adjunctive therapy of acute myeloid leukemia: is it feasible?
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Arsenic Trioxide; Arsenicals; Ce | 2014 |
DESFERRIOXAMINE EFFECT ON IRON EXCRETION IN HEMOCHROMATOSIS.
Topics: Deferoxamine; Hemochromatosis; Hemosiderosis; Humans; Iron; Iron Chelating Agents; Iron Isotopes; Le | 1964 |
Metavanadate suppresses desferrioxamine-induced leukemic cell differentiation with reduced hypoxia-inducible factor-1alpha protein.
Topics: Animals; Blotting, Western; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cell Line, T | 2005 |
Hypoxia-mimetic agents desferrioxamine and cobalt chloride induce leukemic cell apoptosis through different hypoxia-inducible factor-1alpha independent mechanisms.
Topics: Base Sequence; Caspase 3; Caspase 8; Cell Hypoxia; Cell Line, Tumor; Cobalt; Deferoxamine; DNA Prime | 2006 |
Desferrioxamine inhibits induced erythroid differentiation of human leukemic K-562 cells.
Topics: Butyrates; Butyric Acid; Cell Differentiation; Cell Division; Deferoxamine; Erythroblasts; Erythrocy | 1983 |
Tyrosinase-induced phenoxyl radicals of etoposide (VP-16): interaction with reductants in model systems, K562 leukemic cell and nuclear homogenates.
Topics: Ascorbic Acid; Cell Nucleus; Chromatography, High Pressure Liquid; Deferoxamine; Electron Spin Reson | 1993 |
[Purging of hemopoietic progenitor cells in autologous transplantation].
Topics: Adult; Bone Marrow Purging; Child; Cyclophosphamide; Deferoxamine; Etoposide; Hematopoietic Stem Cel | 1997 |
Menadione-induced cell degeneration is related to lipid peroxidation in human cancer cells.
Topics: Calcium; Carcinoma, Hepatocellular; Cell Death; Chelating Agents; Deferoxamine; Dicumarol; Glutathio | 1998 |
Post-translational modifications of eukaryotic initiation factor-5A (eIF-5A) as a new target for anti-cancer therapy.
Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Chelating Agents; Cytarabine; Deferoxamine; Epidermal | 1999 |
Regulation of transferrin receptors by iron in human erythroblasts.
Topics: Blotting, Northern; Deferoxamine; DNA; Endocytosis; Erythroblasts; Hemin; Humans; Iron; Leukemia; Ly | 1992 |
Modulation of transferrin receptor expression by inhibitors of nucleic acid synthesis.
Topics: Animals; Cell Line; Cell Survival; Deferoxamine; DNA Replication; Flow Cytometry; Fluorescence; Huma | 1985 |
[Inhibitory effect of deferoxamine on DNA synthesis in the lymphoid cell lines].
Topics: Deferoxamine; DNA, Neoplasm; Humans; Leukemia; Tumor Cells, Cultured | 1988 |
[Growth inhibition and promotion of differentiation induction in cultured leukemia cell lines by deferoxamine].
Topics: Cell Cycle; Cell Differentiation; Cell Division; Cell Line; Cells, Cultured; Deferoxamine; Humans; L | 1987 |
Inhibition of proliferation of human leukaemic cell populations by deferoxamine.
Topics: Cell Division; Cell Line; Deferoxamine; DNA; Humans; Interphase; Leukemia; Leukemia, Lymphoid; Leuke | 1986 |
A comparison of desferrioxamine-induced sideruria and measurement of labile iron store as indices of body iron status.
Topics: Adult; Anemia, Hypochromic; Anemia, Macrocytic; Autoanalysis; Body Composition; Chelating Agents; De | 1971 |