deferoxamine has been researched along with Leg Ulcer in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Leg Ulcer: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The possible healing effect of deferoxamine and pentoxifylline on persisting lower limb ulcers was studied in 51 patients with thalassemia major." | 9.07 | Effect of pentoxifylline on treatment of lower limb ulcers in patients with thalassemia major. ( Angastiniotis, C; Angelides, NS; Pavlides, N, 1992) |
| "The possible healing effect of deferoxamine and pentoxifylline on persisting lower limb ulcers was studied in 51 patients with thalassemia major." | 5.07 | Effect of pentoxifylline on treatment of lower limb ulcers in patients with thalassemia major. ( Angastiniotis, C; Angelides, NS; Pavlides, N, 1992) |
| "Thalassemia intermedia is a heterogeneous, transfusion-independent form of b-thalassemia, with a clinical course dominated by multi-organ effects of chronic tissue hypoxia, in which hemoglobin F percentage seems to play an important role." | 1.33 | Exchange blood transfusions for the treatment of leg ulcerations in thalassemia intermedia. ( Aessopos, A; Farmakis, D; Kati, M; Polonifi, E; Tsironi, M, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (50.00) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Aessopos, A | 1 |
| Kati, M | 1 |
| Tsironi, M | 1 |
| Polonifi, E | 1 |
| Farmakis, D | 1 |
| Forteleoni, G | 1 |
| Pacitti, C | 1 |
| Mulas, G | 1 |
| Careddu, F | 1 |
| Antona, C | 1 |
| Luscrì, MF | 1 |
| Wenk, J | 1 |
| Foitzik, A | 1 |
| Achterberg, V | 1 |
| Sabiwalsky, A | 1 |
| Dissemond, J | 1 |
| Meewes, C | 1 |
| Reitz, A | 1 |
| Brenneisen, P | 1 |
| Wlaschek, M | 1 |
| Meyer-Ingold, W | 1 |
| Scharffetter-Kochanek, K | 1 |
| Angelides, NS | 1 |
| Angastiniotis, C | 1 |
| Pavlides, N | 1 |
| Festa, RS | 1 |
| Duverne, J | 1 |
| Brizard, CP | 1 |
| Mounier, R | 1 |
1 review available for deferoxamine and Leg Ulcer
| Article | Year |
|---|---|
Modern management of thalassemia.
Topics: Adolescent; Arrhythmias, Cardiac; Ascorbic Acid; Blood Transfusion; Child; Cholelithiasis; Deferoxam | 1985 |
1 trial available for deferoxamine and Leg Ulcer
| Article | Year |
|---|---|
Effect of pentoxifylline on treatment of lower limb ulcers in patients with thalassemia major.
Topics: Adult; Deferoxamine; Female; Humans; Leg Ulcer; Male; Pentoxifylline; Recurrence; Thalassemia | 1992 |
4 other studies available for deferoxamine and Leg Ulcer
| Article | Year |
|---|---|
Exchange blood transfusions for the treatment of leg ulcerations in thalassemia intermedia.
Topics: Adult; beta-Thalassemia; Blood Transfusion; Chelation Therapy; Deferoxamine; Erythrocyte Count; Exch | 2006 |
[Our experience in the treatment of malleolar ulcers in thalassemia].
Topics: Adolescent; Adult; Bandages; Blood Transfusion; Deferoxamine; Female; Humans; Leg Ulcer; Pentoxifyll | 1983 |
Selective pick-up of increased iron by deferoxamine-coupled cellulose abrogates the iron-driven induction of matrix-degrading metalloproteinase 1 and lipid peroxidation in human dermal fibroblasts in vitro: a new dressing concept.
Topics: Bandages; Cellulose; Child; Child, Preschool; Deferoxamine; Enzyme Induction; Fibroblasts; Humans; I | 2001 |
[Inveterate leg ulcer in a constitutional hemolytic syndrome with dermosiderosis. Cure by desfrrioxamine].
Topics: Adult; Deferoxamine; Humans; Leg Ulcer; Male; Siderosis; Skin Diseases; Thalassemia | 1967 |