deferoxamine has been researched along with Kahler Disease in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We examined the antineoplastic effects of the iron chelators, deferasirox and deferoxamine in multiple myeloma cell lines as well as primary myeloma cells." | 3.80 | Iron chelators induce autophagic cell death in multiple myeloma cells. ( Bhatia, R; Donohue, C; Forman, SJ; Krishnan, A; Meng, Z; Pullarkat, V; Synold, TW; Tomassetti, S; Yamamoto, VN, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 3 (50.00) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhong, Y | 1 |
| Tian, F | 1 |
| Ma, H | 1 |
| Wang, H | 1 |
| Yang, W | 1 |
| Liu, Z | 1 |
| Liao, A | 1 |
| Yang, F | 1 |
| Wu, Z | 1 |
| Dai, D | 1 |
| Zhang, L | 1 |
| Zhang, X | 2 |
| Xu, Y | 1 |
| Haney, SL | 1 |
| Varney, ML | 1 |
| Safranek, HR | 1 |
| Chhonker, YS | 1 |
| G-Dayanandan, N | 1 |
| Talmon, G | 1 |
| Murry, DJ | 1 |
| Wiemer, AJ | 1 |
| Wright, DL | 1 |
| Holstein, SA | 1 |
| Pullarkat, V | 1 |
| Meng, Z | 1 |
| Donohue, C | 1 |
| Yamamoto, VN | 1 |
| Tomassetti, S | 1 |
| Bhatia, R | 1 |
| Krishnan, A | 1 |
| Forman, SJ | 1 |
| Synold, TW | 1 |
| Rodríguez, JA | 2 |
| Luria-Pérez, R | 1 |
| López-Valdés, HE | 1 |
| Casero, D | 1 |
| Daniels, TR | 2 |
| Patel, S | 1 |
| Avila, D | 1 |
| Leuchter, R | 1 |
| So, S | 1 |
| Ortiz-Sánchez, E | 1 |
| Bonavida, B | 2 |
| Martínez-Maza, O | 1 |
| Charles, AC | 1 |
| Pellegrini, M | 1 |
| Helguera, G | 2 |
| Penichet, ML | 2 |
| Ng, PP | 1 |
| Lomas, SZ | 1 |
| Schiller, G | 1 |
| Morrison, SL | 1 |
6 other studies available for deferoxamine and Kahler Disease
| Article | Year |
|---|---|
FTY720 induces ferroptosis and autophagy via PP2A/AMPK pathway in multiple myeloma cells.
Topics: Amino Acid Transport System y+; AMP-Activated Protein Kinases; Antineoplastic Agents; Autophagy; Cel | 2020 |
The iron chelator deferoxamine decreases myeloma cell survival.
Topics: Cell Survival; Deferoxamine; Humans; Iron; Iron Chelating Agents; Multiple Myeloma | 2021 |
Tropolone-induced effects on the unfolded protein response pathway and apoptosis in multiple myeloma cells are dependent on iron.
Topics: Animals; Apoptosis; Cell Cycle; Cell Proliferation; Chlorides; Deferoxamine; Female; Ferric Compound | 2019 |
Iron chelators induce autophagic cell death in multiple myeloma cells.
Topics: Autophagy; Benzoates; Cell Line, Tumor; Cell Proliferation; Deferasirox; Deferoxamine; Drug Evaluati | 2014 |
Lethal iron deprivation induced by non-neutralizing antibodies targeting transferrin receptor 1 in malignant B cells.
Topics: Animals; Antibodies; Antigens, CD; B-Lymphocytes; Cell Line; Cell Line, Tumor; Cell Proliferation; C | 2011 |
Molecular events contributing to cell death in malignant human hematopoietic cells elicited by an IgG3-avidin fusion protein targeting the transferrin receptor.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Avidin; Caspase Inhibitors; Cell Line, Tumor; Cell Proli | 2006 |