deferoxamine has been researched along with Invasiveness, Neoplasm in 4 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "However, the effect of DFX on cancer metastasis and the related mechanisms are not well established." | 5.40 | Deferoxamine enhances cell migration and invasion through promotion of HIF-1α expression and epithelial-mesenchymal transition in colorectal cancer. ( Jiang, B; Ma, F; Peng, Y; Shi, X; Wang, J; Wu, Y; Yan, Q; Zhang, W; Zhao, Y, 2014) |
| "Therefore, three bladder cancer cell lines with distinct genetic and molecular backgrounds (T24, 5637 and HT1376) were submitted to hypoxia." | 1.43 | Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension. ( Amaro, T; Azevedo, R; Cotton, S; Fernandes, E; Ferreira, JA; Gaiteiro, C; Lima, L; Neves, M; Oliveira, MJ; Palmeira, C; Parreira, B; Peixoto, A; Rangel, M; Reis, CA; Santos, LL; Silva, AM; Soares, J; Tavares, A; Teixeira, F, 2016) |
| "However, the effect of DFX on cancer metastasis and the related mechanisms are not well established." | 1.40 | Deferoxamine enhances cell migration and invasion through promotion of HIF-1α expression and epithelial-mesenchymal transition in colorectal cancer. ( Jiang, B; Ma, F; Peng, Y; Shi, X; Wang, J; Wu, Y; Yan, Q; Zhang, W; Zhao, Y, 2014) |
| "Glioblastoma multiforme are highly invasive brain tumors." | 1.34 | Involvement of Hif-1 in desferrioxamine-induced invasion of glioblastoma cells. ( Elstner, A; Holtkamp, N; von Deimling, A, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Barrak, NH | 1 |
| Khajah, MA | 1 |
| Luqmani, YA | 1 |
| Zhang, W | 1 |
| Wu, Y | 1 |
| Yan, Q | 1 |
| Ma, F | 1 |
| Shi, X | 1 |
| Zhao, Y | 1 |
| Peng, Y | 1 |
| Wang, J | 1 |
| Jiang, B | 1 |
| Peixoto, A | 1 |
| Fernandes, E | 1 |
| Gaiteiro, C | 1 |
| Lima, L | 1 |
| Azevedo, R | 1 |
| Soares, J | 1 |
| Cotton, S | 1 |
| Parreira, B | 1 |
| Neves, M | 1 |
| Amaro, T | 1 |
| Tavares, A | 1 |
| Teixeira, F | 1 |
| Palmeira, C | 1 |
| Rangel, M | 1 |
| Silva, AM | 1 |
| Reis, CA | 1 |
| Santos, LL | 1 |
| Oliveira, MJ | 1 |
| Ferreira, JA | 1 |
| Elstner, A | 1 |
| Holtkamp, N | 1 |
| von Deimling, A | 1 |
4 other studies available for deferoxamine and Invasiveness, Neoplasm
| Article | Year |
|---|---|
Hypoxic environment may enhance migration/penetration of endocrine resistant MCF7- derived breast cancer cells through monolayers of other non-invasive cancer cells in vitro.
Topics: Basement Membrane; Breast Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Movement; Cobalt; Cocultur | 2020 |
Deferoxamine enhances cell migration and invasion through promotion of HIF-1α expression and epithelial-mesenchymal transition in colorectal cancer.
Topics: Cadherins; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; | 2014 |
Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Antigens, Neoplasm; Carbonic Anhydrase IX; Cell Hypoxi | 2016 |
Involvement of Hif-1 in desferrioxamine-induced invasion of glioblastoma cells.
Topics: Blotting, Western; Brain Neoplasms; Cell Line, Tumor; Cell Separation; Deferoxamine; Flow Cytometry; | 2007 |