deferoxamine has been researched along with Intracranial Hemorrhages in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Intracranial Hemorrhages: Bleeding within the SKULL, including hemorrhages in the brain and the three membranes of MENINGES. The escape of blood often leads to the formation of HEMATOMA in the cranial epidural, subdural, and subarachnoid spaces.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Iron chelation and iron overload was achieved by deferoxamine mesylate or iron dextran injection." | 8.02 | Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice. ( Chen, WX; Feng, H; Ge, HF; Guo, C; Li, CC; Tang, XQ; Wang, B; Wang, J; Xia, M; Yin, Y, 2021) |
| " This study examined the role of deferoxamine (DFX) in brain injury and HT in a rat model of transient focal ischemia with hyperglycemia." | 7.75 | Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia. ( Hua, Y; Keep, RF; Xi, G; Xing, Y, 2009) |
| " Iron chelation and iron overload was achieved by deferoxamine mesylate or iron dextran injection." | 4.02 | Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice. ( Chen, WX; Feng, H; Ge, HF; Guo, C; Li, CC; Tang, XQ; Wang, B; Wang, J; Xia, M; Yin, Y, 2021) |
| "These results indicate that membrane attack complex and erythrophagocytosis contribute to hematoma clearance after ICH, which can be altered by deferoxamine treatment." | 3.83 | Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage. ( Cao, S; Chen, G; Hua, Y; Keep, RF; Xi, G; Zheng, M, 2016) |
| " This study examined the role of deferoxamine (DFX) in brain injury and HT in a rat model of transient focal ischemia with hyperglycemia." | 3.75 | Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia. ( Hua, Y; Keep, RF; Xi, G; Xing, Y, 2009) |
| "Deferoxamine was used as an iron chelator." | 1.33 | Long-term effects of experimental intracerebral hemorrhage: the role of iron. ( Hoff, JT; Hua, Y; Keep, RF; Nakamura, T; Schallert, T; Wu, J; Xi, G, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pandey, AS | 1 |
| Daou, BJ | 1 |
| Chaudhary, N | 1 |
| Xi, G | 4 |
| Wang, J | 1 |
| Tang, XQ | 1 |
| Xia, M | 1 |
| Li, CC | 1 |
| Guo, C | 1 |
| Ge, HF | 1 |
| Yin, Y | 1 |
| Wang, B | 1 |
| Chen, WX | 1 |
| Feng, H | 1 |
| Klebe, D | 1 |
| Krafft, PR | 1 |
| Hoffmann, C | 1 |
| Lekic, T | 1 |
| Flores, JJ | 1 |
| Rolland, W | 1 |
| Zhang, JH | 1 |
| Cao, S | 1 |
| Zheng, M | 1 |
| Hua, Y | 3 |
| Chen, G | 1 |
| Keep, RF | 3 |
| Xing, Y | 1 |
| Nakamura, T | 1 |
| Wu, J | 1 |
| Schallert, T | 1 |
| Hoff, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety of Surgical Treatment In Severe Primary Pontine Hemorrhage Evacuation (STIPE): a Multicentric, Randomized, Controlled, Open-label Trial[NCT04647162] | 64 participants (Anticipated) | Interventional | 2022-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for deferoxamine and Intracranial Hemorrhages
| Article | Year |
|---|---|
A combination of Deferoxamine mesylate and minimally invasive surgery with hematoma lysis for evacuation of intracerebral hemorrhage.
Topics: Clinical Trials as Topic; Deferoxamine; Female; Humans; Intracranial Hemorrhages; Male; Minimally In | 2020 |
5 other studies available for deferoxamine and Intracranial Hemorrhages
| Article | Year |
|---|---|
Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice.
Topics: Angiotensin II; Animals; Cerebral Hemorrhage; Deferoxamine; Drug Combinations; Hemoglobins; Hyperten | 2021 |
Acute and delayed deferoxamine treatment attenuates long-term sequelae after germinal matrix hemorrhage in neonatal rats.
Topics: Animals; Animals, Newborn; Brain; Deferoxamine; Disease Models, Animal; Intracranial Hemorrhages; Ma | 2014 |
Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage.
Topics: Animals; Complement Membrane Attack Complex; Deferoxamine; Disease Models, Animal; Hematoma; Hemolys | 2016 |
Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Chemistry; Brain Edema; Deferoxamine; Hemoglo | 2009 |
Long-term effects of experimental intracerebral hemorrhage: the role of iron.
Topics: Animals; Atrophy; Behavior, Animal; Brain; Deferoxamine; Ferritins; Intracranial Hemorrhages; Iron; | 2006 |