deferoxamine has been researched along with Infections, Plasmodium in 26 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice." | 7.68 | Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R, 1992) |
| "The mechanism whereby deferoxamine (DF) inhibits the growth of malaria parasites was studied in rats infected with Plasmodium berghei." | 7.67 | Deferoxamine inhibition of malaria is independent of host iron status. ( Hershko, C; Peto, TE, 1988) |
| "Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity." | 6.69 | Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. ( Chantharaksri, U; Dangdoungjai, J; Looareesuiwan, S; Pipitaporn, B; Sibmooh, N; Udomsangpetch, R; Wilairatana, P, 2000) |
| "A combination therapy was tested consisting of chloroquine and interferon-gamma (IFN-gamma) in the late phase of blood-stage Plasmodium vinckei malaria in BALB/c mice." | 3.68 | Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine. ( Bienzle, U; Chaves, MF; Kremsner, PG; Neifer, S; Rudolph, R, 1992) |
| "The mechanism whereby deferoxamine (DF) inhibits the growth of malaria parasites was studied in rats infected with Plasmodium berghei." | 3.67 | Deferoxamine inhibition of malaria is independent of host iron status. ( Hershko, C; Peto, TE, 1988) |
| "Treatment with artemisinin alone showed no effect on plasma TBARs, and did not alter the membrane fluidity." | 2.69 | Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria. ( Chantharaksri, U; Dangdoungjai, J; Looareesuiwan, S; Pipitaporn, B; Sibmooh, N; Udomsangpetch, R; Wilairatana, P, 2000) |
| "Parasitemia was reduced by all three treatment regimens; however, long-term survival was obtained only by treatment with liposomal DFO (days 7 and 8, 400 mg/kg/day)." | 1.30 | Plasmodium vinckei: optimization of desferrioxamine B delivery in the treatment of murine malaria. ( Eling, WM; Hermsen, CC; Postma, NS; Zuidema, J, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (38.46) | 18.7374 |
| 1990's | 7 (26.92) | 18.2507 |
| 2000's | 6 (23.08) | 29.6817 |
| 2010's | 3 (11.54) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, J | 1 |
| Obando, D | 1 |
| Liao, V | 1 |
| Lifa, T | 1 |
| Codd, R | 1 |
| Rodrigues, T | 1 |
| Prudêncio, M | 1 |
| Moreira, R | 1 |
| Mota, MM | 1 |
| Lopes, F | 1 |
| Isah, MB | 1 |
| Ibrahim, MA | 1 |
| Gordeuk, VR | 2 |
| Loyevsky, M | 1 |
| Ridley, RG | 1 |
| Omari, A | 1 |
| Garner, P | 1 |
| Huang, F | 1 |
| Tang, LH | 1 |
| Golenser, J | 1 |
| Domb, A | 1 |
| Mordechai-Daniel, T | 1 |
| Leshem, B | 1 |
| Luty, A | 1 |
| Kremsner, P | 1 |
| Pollack, S | 2 |
| Clark, IA | 4 |
| Cowden, WB | 3 |
| Hunt, NH | 3 |
| Maxwell, LE | 2 |
| Mackie, EJ | 2 |
| Hershko, C | 2 |
| Thuma, PE | 1 |
| Brittenham, GM | 1 |
| Postma, NS | 1 |
| Hermsen, CC | 1 |
| Zuidema, J | 1 |
| Eling, WM | 1 |
| Srivastava, PJ | 1 |
| Chandra, S | 2 |
| Arif, AJ | 2 |
| Singh, C | 2 |
| Panday, V | 1 |
| Sibmooh, N | 1 |
| Pipitaporn, B | 1 |
| Wilairatana, P | 1 |
| Dangdoungjai, J | 1 |
| Udomsangpetch, R | 1 |
| Looareesuiwan, S | 1 |
| Chantharaksri, U | 1 |
| Kremsner, PG | 1 |
| Neifer, S | 1 |
| Chaves, MF | 1 |
| Rudolph, R | 1 |
| Bienzle, U | 1 |
| Traore, O | 1 |
| Carnevale, P | 1 |
| Kaptue-Noche, L | 1 |
| M'Bede, J | 1 |
| Desfontaine, M | 1 |
| Elion, J | 1 |
| Labie, D | 1 |
| Nagel, RL | 1 |
| Lytton, SD | 1 |
| Cabantchik, ZI | 1 |
| Libman, J | 1 |
| Shanzer, A | 1 |
| Chaudhri, G | 1 |
| Stahel, E | 1 |
| Mazier, D | 1 |
| Guillouzo, A | 1 |
| Miltgen, F | 1 |
| Landau, I | 1 |
| Mellouk, S | 1 |
| Beaudoin, RL | 1 |
| Langlois, P | 1 |
| Gentilini, M | 1 |
| Peto, TE | 1 |
| Rossan, RN | 1 |
| Davidson, DE | 1 |
| Escajadillo, A | 1 |
| Mathur, PD | 1 |
| Sen, AB | 1 |
| Fritsch, G | 1 |
| Treumer, J | 1 |
| Spira, DT | 1 |
| Jung, A | 1 |
8 reviews available for deferoxamine and Infections, Plasmodium
| Article | Year |
|---|---|
The many faces of the adamantyl group in drug design.
Topics: Adamantane; Animals; Antimalarials; Diabetes Mellitus, Type 2; Drug Design; Humans; Hypoglycemic Age | 2011 |
Targeting the liver stage of malaria parasites: a yet unmet goal.
Topics: Animals; Antimalarials; Humans; Life Cycle Stages; Liver; Malaria; Plasmodium; Structure-Activity Re | 2012 |
The role of antioxidants treatment on the pathogenesis of malarial infections: a review.
Topics: Acetylcysteine; Antimalarials; Antioxidants; Ascorbic Acid; Deferoxamine; Folic Acid; Humans; Malari | 2014 |
Antimalarial effect of iron chelators.
Topics: Animals; Antimalarials; Child; Deferiprone; Deferoxamine; Drug Therapy, Combination; Humans; In Vitr | 2002 |
Malaria in endemic areas.
Topics: Antimalarials; Artemether; Artemisinins; Blood Transfusion; Chloroquine; Deferoxamine; Drug Combinat | 2003 |
[Research progress on iron chelator for malaria therapy].
Topics: Animals; Antimalarials; Deferoxamine; Humans; Iron Chelating Agents; Malaria; Razoxane | 2005 |
Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators.
Topics: Animals; Brain; Cell Division; Chelation Therapy; Deferoxamine; Graft Rejection; Heart; Humans; Iron | 1994 |
Iron chelation therapy for malaria.
Topics: Adult; Animals; Deferoxamine; Erythrocytes; Ferritins; Hemoglobins; Humans; Iron; Iron Chelating Age | 1994 |
2 trials available for deferoxamine and Infections, Plasmodium
| Article | Year |
|---|---|
Effect of artemisinin on lipid peroxidation and fluidity of the erythrocyte membrane in malaria.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; Cyclic N-Oxides; Deferoxamine; Double-Blind Method | 2000 |
Preliminary report on the use of desferrioxamine in the treatment of Plasmodium falciparum malaria.
Topics: Animals; Chloroquine; Deferoxamine; Drug Therapy, Combination; Humans; Malaria; Parasite Egg Count; | 1991 |
16 other studies available for deferoxamine and Infections, Plasmodium
| Article | Year |
|---|---|
Malaria: to kill a parasite.
Topics: Animals; Artemisinins; Calcium-Transporting ATPases; Deferoxamine; Iron; Iron Chelating Agents; Mala | 2003 |
Iron chelators: correlation between effects on Plasmodium spp. and immune functions.
Topics: Aldehydes; Animals; B-Lymphocytes; Cells, Cultured; Deferoxamine; Disease Models, Animal; Humans; Hy | 2006 |
Malaria and iron.
Topics: Deferoxamine; Female; Heme; Humans; Iron Deficiencies; Malaria; Plasmodium; Plasmodium falciparum; P | 1983 |
Activity of divicine in Plasmodium vinckei-infected mice has implications for treatment of favism and epidemiology of G-6-PD deficiency.
Topics: Animals; Deferoxamine; Erythrocytes; Favism; Female; Glucosephosphate Dehydrogenase Deficiency; Glut | 1984 |
Radical-mediated damage to parasites and erythrocytes in Plasmodium vinckei infected mice after injection of t-butyl hydroperoxide.
Topics: Animals; Deferoxamine; Erythrocytes; Female; Free Radicals; Glutathione; Hemolysis; Malaria; Male; M | 1984 |
Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria.
Topics: Alloxan; Animals; Deferoxamine; Erythrocytes; Female; Free Radicals; Hemolysis; Hydrogen Peroxide; M | 1983 |
Plasmodium vinckei: optimization of desferrioxamine B delivery in the treatment of murine malaria.
Topics: Animals; Deferoxamine; Delayed-Action Preparations; Drug Carriers; Drug Delivery Systems; Female; In | 1998 |
Metal chelators/antioxidants: approaches to protect erythrocytic oxidative stress injury during Plasmodium berghei infection in Mastomys coucha.
Topics: Animals; Antioxidants; Catechin; Chelating Agents; Deferoxamine; Erythrocytes; Glutathione; Lipid Pe | 1999 |
Interferon-gamma induced lethality in the late phase of Plasmodium vinckei malaria despite effective parasite clearance by chloroquine.
Topics: Animals; Arginine; Chloroquine; Deferoxamine; Female; Immunization; Interferon-gamma; Liver; Malaria | 1992 |
Reversed siderophores as antimalarial agents. II. Selective scavenging of Fe(III) from parasitized erythrocytes by a fluorescent derivative of desferal.
Topics: 4-Chloro-7-nitrobenzofurazan; Animals; Antimalarials; Cell Membrane Permeability; Chelating Agents; | 1991 |
Possible roles for oxidants, through tumor necrosis factor, in malarial anemia.
Topics: Alloxan; Animals; Antioxidants; Cells, Cultured; Deferoxamine; Hydrogen Peroxide; Lipopolysaccharide | 1989 |
Iron chelators: in vitro inhibitory effect on the liver stage of rodent and human malaria.
Topics: Animals; Cells, Cultured; Deferoxamine; Dihydropyridines; Humans; Iron Chelating Agents; Liver; Mala | 1988 |
Deferoxamine inhibition of malaria is independent of host iron status.
Topics: Animals; Deferoxamine; Erythrocyte Indices; Erythrocytes; Female; Hematocrit; Hemoglobins; Iron; Iro | 1988 |
Desferrioxamine suppresses Plasmodium falciparum in Aotus monkeys.
Topics: Animals; Aotus trivirgatus; Deferoxamine; Malaria; Plasmodium falciparum | 1987 |
Effect of a specific iron chelator, desferrioxamine on the host biochemistry and parasitaemia in mice infected with Plasmodium berghei.
Topics: Aminopyrine N-Demethylase; Animals; Deferoxamine; Iron; Lipid Peroxides; Malaria; Male; Mice; Plasmo | 1985 |
Plasmodium vinckei: suppression of mouse infections with desferrioxamine B.
Topics: Animals; Deferoxamine; Malaria; Mice; Plasmodium; Time Factors | 1985 |