deferoxamine has been researched along with Hypoxia-Ischemia, Brain in 12 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Hypoxia-Ischemia, Brain: A disorder characterized by a reduction of oxygen in the blood combined with reduced blood flow (ISCHEMIA) to the brain from a localized obstruction of a cerebral artery or from systemic hypoperfusion. Prolonged hypoxia-ischemia is associated with ISCHEMIC ATTACK, TRANSIENT; BRAIN INFARCTION; BRAIN EDEMA; COMA; and other conditions.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Preconditioning with hypoxia and hypoxia-mimetic compounds cobalt chloride (CoCl2) and desferrioxamine (DFX) protects against hypoxic-ischemic (HI) injury in neonatal rat brain." | 7.74 | Long-term functional and protective actions of preconditioning with hypoxia, cobalt chloride, and desferrioxamine against hypoxic-ischemic injury in neonatal rats. ( Beart, PM; Callaway, JK; Jones, NM; Kardashyan, L; Lee, EM, 2008) |
| "Preconditioning with hypoxia and hypoxia-mimetic compounds cobalt chloride (CoCl2) and desferrioxamine (DFX) protects against hypoxic-ischemic (HI) injury in neonatal rat brain." | 3.74 | Long-term functional and protective actions of preconditioning with hypoxia, cobalt chloride, and desferrioxamine against hypoxic-ischemic injury in neonatal rats. ( Beart, PM; Callaway, JK; Jones, NM; Kardashyan, L; Lee, EM, 2008) |
| "Rat model of cerebral ischemia was established by middle cerebral artery occlusion with or without DFO administration." | 1.35 | Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin. ( Ding, SJ; Guo, W; Li, YX; Xiao, L; Zhan, Q, 2008) |
| "Allopurinol treatment was not as effective as 2-iminobiotin treatment after HI." | 1.31 | Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective. ( Braun, K; Groenendaal, F; Ioroi, T; Nicolay, K; Peeters-Scholte, C; Post, I; van Bel, F; van den Tweel, E; Veldhuis, W, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 10 (83.33) | 29.6817 |
| 2010's | 1 (8.33) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, NM | 2 |
| Nathanson, AD | 1 |
| Chell, S | 1 |
| DeAngelis, E | 1 |
| Whelan, G | 1 |
| Willé, D | 1 |
| Cheng, K | 1 |
| Lu, Q | 1 |
| Harris, VA | 1 |
| Rafikov, R | 1 |
| Sun, X | 1 |
| Kumar, S | 1 |
| Black, SM | 1 |
| van der Kooij, MA | 1 |
| Groenendaal, F | 5 |
| Kavelaars, A | 1 |
| Heijnen, CJ | 1 |
| van Bel, F | 5 |
| Peeters-Scholte, C | 3 |
| van den Tweel, E | 2 |
| Ioroi, T | 1 |
| Post, I | 1 |
| Braun, K | 2 |
| Veldhuis, W | 1 |
| Nicolay, K | 2 |
| Koster, J | 1 |
| Kops, N | 1 |
| Blomgren, K | 1 |
| Buonocore, G | 1 |
| van Buul-Offers, S | 1 |
| Hagberg, H | 1 |
| Pichiule, P | 1 |
| Chavez, JC | 1 |
| Schmidt, AM | 1 |
| Vannucci, SJ | 1 |
| Papazisis, G | 1 |
| Pourzitaki, C | 1 |
| Sardeli, C | 1 |
| Lallas, A | 1 |
| Amaniti, E | 1 |
| Kouvelas, D | 1 |
| Kardashyan, L | 1 |
| Callaway, JK | 1 |
| Lee, EM | 1 |
| Beart, PM | 1 |
| Li, YX | 1 |
| Ding, SJ | 1 |
| Xiao, L | 1 |
| Guo, W | 1 |
| Zhan, Q | 1 |
| Sarco, DP | 1 |
| Becker, J | 1 |
| Palmer, C | 1 |
| Sheldon, RA | 1 |
| Ferriero, DM | 1 |
| Shadid, M | 1 |
| McGowan, JE | 1 |
| Mishra, OP | 1 |
12 other studies available for deferoxamine and Hypoxia-Ischemia, Brain
| Article | Year |
|---|---|
The prolyl hydroxylase inhibitor GSK1120360A reduces early brain injury, but protection is not maintained in a neonatal rat model of hypoxic ischaemic encephalopathy.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Deferoxamine; Hypoxia; Hypoxia-Ischemia, Brain; Me | 2022 |
Nitric oxide induces hypoxia ischemic injury in the neonatal brain via the disruption of neuronal iron metabolism.
Topics: Aconitate Hydratase; Animals; Animals, Newborn; Cell Death; Cell Hypoxia; Culture Media; Deferoxamin | 2015 |
Combination of deferoxamine and erythropoietin: therapy for hypoxia-ischemia-induced brain injury in the neonatal rat?
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Antioxidants; Brain Infarction; Caspase 3; Cere | 2009 |
Pharmacological interventions in the newborn piglet in the first 24 h after hypoxia-ischemia. A hemodynamic and electrophysiological perspective.
Topics: Allopurinol; Animals; Animals, Newborn; Biotin; Cerebral Cortex; Deferoxamine; Electroencephalograph | 2002 |
Effects of allopurinol and deferoxamine on reperfusion injury of the brain in newborn piglets after neonatal hypoxia-ischemia.
Topics: Allopurinol; Animals; Animals, Newborn; Brain; Caspase 3; Caspases; Deferoxamine; Enzyme Inhibitors; | 2003 |
Redox state of near infrared spectroscopy-measured cytochrome aa(3) correlates with delayed cerebral energy failure following perinatal hypoxia-ischaemia in the newborn pig.
Topics: Allopurinol; Animals; Animals, Newborn; Biotin; Brain; Cell Survival; Deferoxamine; Disease Models, | 2004 |
Hypoxia-inducible factor-1 mediates neuronal expression of the receptor for advanced glycation end products following hypoxia/ischemia.
Topics: Animals; Brain Infarction; Cell Death; Cell Hypoxia; Deferoxamine; Female; Hypoxia-Inducible Factor | 2007 |
Deferoxamine decreases the excitatory amino acid levels and improves the histological outcome in the hippocampus of neonatal rats after hypoxia-ischemia.
Topics: Animals; Animals, Newborn; Aspartic Acid; Deferoxamine; Excitatory Amino Acids; Female; Glutamic Aci | 2008 |
Long-term functional and protective actions of preconditioning with hypoxia, cobalt chloride, and desferrioxamine against hypoxic-ischemic injury in neonatal rats.
Topics: Animals; Animals, Newborn; Behavior, Animal; Brain; Cobalt; Deferoxamine; Disease Models, Animal; Fe | 2008 |
Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Infarction; Deferoxamine; Disease Models, Animal; | 2008 |
The neuroprotective effect of deferoxamine in the hypoxic-ischemic immature mouse brain.
Topics: Animals; Animals, Newborn; Brain; Deferoxamine; Histological Techniques; Hypoxia-Ischemia, Brain; Mi | 2000 |
Effects of deferoxamine, a chelator of free iron, on NA(+), K(+)-ATPase activity of cortical brain cell membrane during early reperfusion after hypoxia-ischemia in newborn lambs.
Topics: Animals; Animals, Newborn; Cell Membrane; Cerebral Cortex; Deferoxamine; Electroencephalography; Hyp | 2000 |