deferoxamine has been researched along with Hypertension in 7 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Hypertension: Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Iron chelation and iron overload was achieved by deferoxamine mesylate or iron dextran injection." | 8.02 | Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice. ( Chen, WX; Feng, H; Ge, HF; Guo, C; Li, CC; Tang, XQ; Wang, B; Wang, J; Xia, M; Yin, Y, 2021) |
| " Iron chelation and iron overload was achieved by deferoxamine mesylate or iron dextran injection." | 4.02 | Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice. ( Chen, WX; Feng, H; Ge, HF; Guo, C; Li, CC; Tang, XQ; Wang, B; Wang, J; Xia, M; Yin, Y, 2021) |
| "These results suggest that superoxide anions in the RVLM, which generate hydroxyl radicals, are increased in SHRSP and contribute to the neural mechanisms of hypertension in SHRSP." | 3.72 | Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats. ( Hirooka, Y; Ito, K; Kimura, Y; Kishi, T; Shimokawa, H; Takeshita, A, 2004) |
| " Inducing acute hypertension (coronary pressure 200 mmHg) pharmacologically with angiotensin II also augmented constriction to serotonin, whereas phenylephrine-induced hypertension did not." | 3.69 | Effect of acute hypertension in the coronary circulation: role of mechanical factors and oxygen radicals. ( Cappelli-Bigazzi, M; De Bruyn, VH; Dole, WP; Lamping, KG; Nuno, DW, 1994) |
| "We have investigated whether long-term administration of angiotensin (Ang) II causes ferritin induction and iron accumulation in the rat aorta, and their possible relation to regulatory effects on gene expression and vascular function in Ang II-infused animals." | 1.33 | Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats. ( Ishizaka, N; Matsuzaki, G; Mori, I; Nagai, R; Ohno, M; Saito, K, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 2 (28.57) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Li, X | 1 |
| Wang, S | 1 |
| Miao, R | 1 |
| Zhong, J | 1 |
| Wang, J | 1 |
| Tang, XQ | 1 |
| Xia, M | 1 |
| Li, CC | 1 |
| Guo, C | 1 |
| Ge, HF | 1 |
| Yin, Y | 1 |
| Wang, B | 1 |
| Chen, WX | 1 |
| Feng, H | 1 |
| Kishi, T | 1 |
| Hirooka, Y | 1 |
| Kimura, Y | 1 |
| Ito, K | 1 |
| Shimokawa, H | 1 |
| Takeshita, A | 1 |
| Ishizaka, N | 1 |
| Saito, K | 1 |
| Mori, I | 1 |
| Matsuzaki, G | 1 |
| Ohno, M | 1 |
| Nagai, R | 1 |
| De Bruyn, VH | 1 |
| Nuno, DW | 1 |
| Cappelli-Bigazzi, M | 1 |
| Dole, WP | 1 |
| Lamping, KG | 1 |
| Kinoshita, H | 1 |
| Kakutani, T | 1 |
| Iranami, H | 1 |
| Hatano, Y | 1 |
| Yang, ST | 1 |
| Mayhan, WG | 1 |
| Faraci, FM | 1 |
| Heistad, DD | 1 |
1 review available for deferoxamine and Hypertension
| Article | Year |
|---|---|
Targeting Iron Metabolism and Ferroptosis as Novel Therapeutic Approaches in Cardiovascular Diseases.
Topics: Cardiovascular Diseases; Deferoxamine; Ferroptosis; Humans; Hypertension; Iron; Lipid Peroxidation; | 2023 |
6 other studies available for deferoxamine and Hypertension
| Article | Year |
|---|---|
Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice.
Topics: Angiotensin II; Animals; Cerebral Hemorrhage; Deferoxamine; Drug Combinations; Hemoglobins; Hyperten | 2021 |
Increased reactive oxygen species in rostral ventrolateral medulla contribute to neural mechanisms of hypertension in stroke-prone spontaneously hypertensive rats.
Topics: 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt; Animals; Blood Pressure; Brain Chemistry; Ca | 2004 |
Iron chelation suppresses ferritin upregulation and attenuates vascular dysfunction in the aorta of angiotensin II-infused rats.
Topics: Aldehydes; Angiotensin II; Animals; Aorta; Aortic Diseases; Apoferritins; Chemokine CCL2; Deferoxami | 2005 |
Effect of acute hypertension in the coronary circulation: role of mechanical factors and oxygen radicals.
Topics: Angiotensin II; Animals; Biomechanical Phenomena; Blood Pressure; Catalase; Coronary Circulation; De | 1994 |
The role of oxygen-derived free radicals in augmented relaxations to levcromakalim in the aorta from hypertensive rats.
Topics: Animals; Aorta; Blood Pressure; Catalase; Cromakalim; Deferoxamine; Dose-Response Relationship, Drug | 2001 |
Mechanisms of impaired endothelium-dependent cerebral vasodilatation in response to bradykinin in hypertensive rats.
Topics: Animals; Arterioles; Bradykinin; Cerebral Arteries; Cerebrovascular Circulation; Deferoxamine; Endot | 1991 |