deferoxamine has been researched along with Hemorrhagic Shock in 16 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the pulmonary oxidative stress and possible protective effect of N-Acetylcysteine (NAC) and Desferoxamine (DFX)in a porcine model subjected to hemorrhagic shock." | 7.85 | N-Acetylcysteine and Desferoxamine Reduce Pulmonary Oxidative Stress Caused by Hemorrhagic Shock in a Porcine Model. ( Arkadopoulos, N; Karmaniolou, I; Mani, A; Mylonas, A; Nomikos, T; Orfanos, N; Pafiti, A; Papalois, A; Smyrniotis, V; Staikou, C; Theodoraki, K, 2017) |
| " Use of deferoxamine, an iron chelator and oxygen-free radical scavenger, and hespan (hydroxyethyl starch), a colloid plasma expander, was evaluated in a rat hemorrhagic shock model." | 7.71 | Deferoxamine and hespan complex as a resuscitative adjuvant in hemorrhagic shock rat model. ( Ali, MA; Chang, YJ; Rana, MW; Shapiro, MJ; Taylor, WH, 2002) |
| "This study investigated whether hepatocyte Ca2+ dysregulation after hemorrhagic shock and resuscitation could be modulated by the iron chelator hydroxyethyl starch-conjugated deferoxamine (HES-DFO)." | 7.70 | Starch-deferoxamine conjugate inhibits hepatocyte Ca2+ uptake during hemorrhagic shock and resuscitation. ( Pizanis, A; Rose, S; Silomon, M, 2000) |
| "The animals remained in hemorrhagic shock for 45 minutes, followed by 1 hour of resuscitation." | 5.29 | Superoxide dismutase and allopurinol improve survival in an animal model of hemorrhagic shock. ( Chhieng, N; Clark, L; Eloi, L; Miller, B; Tan, LR; Waxman, K; Young, A, 1993) |
| "Iron released into the plasma in hemorrhagic shock may contribute to cellular damage by catalyzing lipid peroxidation of cell membranes." | 5.28 | Iron chelation with a deferoxamine conjugate in hemorrhagic shock. ( Bubrick, MP; Jacobs, DM; Julsrud, JM, 1991) |
| "To investigate the pulmonary oxidative stress and possible protective effect of N-Acetylcysteine (NAC) and Desferoxamine (DFX)in a porcine model subjected to hemorrhagic shock." | 3.85 | N-Acetylcysteine and Desferoxamine Reduce Pulmonary Oxidative Stress Caused by Hemorrhagic Shock in a Porcine Model. ( Arkadopoulos, N; Karmaniolou, I; Mani, A; Mylonas, A; Nomikos, T; Orfanos, N; Pafiti, A; Papalois, A; Smyrniotis, V; Staikou, C; Theodoraki, K, 2017) |
| "The aim of this study is to assess the efficacy of the combination of N-acetylcysteine (NAC) and deferoxamine (DFO) in the resuscitation from hemorrhagic shock in a porcine model of bleeding during hepatectomy." | 3.83 | The effects of antioxidants on a porcine model of liver hemorrhage. ( Arkadopoulos, NF; Dimas, C; Karmaniolou, II; Kondi-Pafiti, AI; Lolis, ED; Mylonas, AI; Orfanos, NF; Papalois, AE; Smyrniotis, VE; Stergiou, IP, 2016) |
| " Use of deferoxamine, an iron chelator and oxygen-free radical scavenger, and hespan (hydroxyethyl starch), a colloid plasma expander, was evaluated in a rat hemorrhagic shock model." | 3.71 | Deferoxamine and hespan complex as a resuscitative adjuvant in hemorrhagic shock rat model. ( Ali, MA; Chang, YJ; Rana, MW; Shapiro, MJ; Taylor, WH, 2002) |
| "This study investigated whether hepatocyte Ca2+ dysregulation after hemorrhagic shock and resuscitation could be modulated by the iron chelator hydroxyethyl starch-conjugated deferoxamine (HES-DFO)." | 3.70 | Starch-deferoxamine conjugate inhibits hepatocyte Ca2+ uptake during hemorrhagic shock and resuscitation. ( Pizanis, A; Rose, S; Silomon, M, 2000) |
| "To determine the effects of a hydroxyethyl starch-deferoxamine conjugate on hepatic microcirculation in an isobaric, anesthetized rat model of hemorrhagic shock and asanguineous resuscitation." | 3.69 | Attenuation of shock-induced hepatic microcirculatory disturbances by the use of a starch-deferoxamine conjugate for resuscitation. ( Bauer, M; Feucht, K; Marzi, I; Ziegenfuss, T, 1995) |
| "The animals remained in hemorrhagic shock for 45 minutes, followed by 1 hour of resuscitation." | 1.29 | Superoxide dismutase and allopurinol improve survival in an animal model of hemorrhagic shock. ( Chhieng, N; Clark, L; Eloi, L; Miller, B; Tan, LR; Waxman, K; Young, A, 1993) |
| "Iron released into the plasma in hemorrhagic shock may contribute to cellular damage by catalyzing lipid peroxidation of cell membranes." | 1.28 | Iron chelation with a deferoxamine conjugate in hemorrhagic shock. ( Bubrick, MP; Jacobs, DM; Julsrud, JM, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (18.75) | 18.7374 |
| 1990's | 8 (50.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Orfanos, NF | 1 |
| Mylonas, AI | 1 |
| Karmaniolou, II | 1 |
| Stergiou, IP | 1 |
| Lolis, ED | 1 |
| Dimas, C | 1 |
| Papalois, AE | 1 |
| Kondi-Pafiti, AI | 1 |
| Smyrniotis, VE | 1 |
| Arkadopoulos, NF | 1 |
| Mani, A | 1 |
| Staikou, C | 1 |
| Karmaniolou, I | 1 |
| Orfanos, N | 1 |
| Mylonas, A | 1 |
| Nomikos, T | 1 |
| Pafiti, A | 1 |
| Papalois, A | 1 |
| Arkadopoulos, N | 1 |
| Smyrniotis, V | 1 |
| Theodoraki, K | 1 |
| Bauer, M | 2 |
| Feucht, K | 1 |
| Ziegenfuss, T | 1 |
| Marzi, I | 3 |
| Tan, LR | 1 |
| Waxman, K | 1 |
| Clark, L | 1 |
| Eloi, L | 1 |
| Chhieng, N | 1 |
| Miller, B | 1 |
| Young, A | 1 |
| Bauer, C | 2 |
| Larsen, R | 2 |
| Walcher, F | 1 |
| Holanda, M | 1 |
| Mertzlufft, F | 1 |
| Rose, S | 1 |
| Pizanis, A | 1 |
| Silomon, M | 1 |
| Paxian, M | 1 |
| Rensing, H | 1 |
| Rickauer, A | 1 |
| Schönhofen, S | 1 |
| Schmeck, J | 1 |
| Pannen, BH | 1 |
| Bauer, I | 1 |
| Rana, MW | 1 |
| Shapiro, MJ | 1 |
| Ali, MA | 1 |
| Chang, YJ | 1 |
| Taylor, WH | 1 |
| Jacobs, DM | 1 |
| Julsrud, JM | 1 |
| Bubrick, MP | 1 |
| Fleckenstein, AE | 1 |
| Smith, SL | 1 |
| Linseman, KL | 1 |
| Beuving, LJ | 1 |
| Hall, ED | 1 |
| Zager, RA | 1 |
| Deitch, EA | 1 |
| Bridges, W | 1 |
| Berg, R | 1 |
| Specian, RD | 1 |
| Granger, DN | 1 |
| Sanan, S | 3 |
| Sharma, G | 3 |
| Singh, B | 1 |
| Sanan, DP | 2 |
| Wadhera, P | 1 |
| Malhotra, R | 1 |
| Jain, P | 1 |
| Vadhera, P | 1 |
16 other studies available for deferoxamine and Hemorrhagic Shock
| Article | Year |
|---|---|
The effects of antioxidants on a porcine model of liver hemorrhage.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Crystalloid Solutions; Deferoxamine; Disease Model | 2016 |
N-Acetylcysteine and Desferoxamine Reduce Pulmonary Oxidative Stress Caused by Hemorrhagic Shock in a Porcine Model.
Topics: Acetylcysteine; Animals; Biomarkers; Colloids; Crystalloid Solutions; Deferoxamine; Disease Models, | 2017 |
Attenuation of shock-induced hepatic microcirculatory disturbances by the use of a starch-deferoxamine conjugate for resuscitation.
Topics: Animals; Cell Adhesion; Deferoxamine; Endothelium, Vascular; Female; Hematocrit; Hydroxyethyl Starch | 1995 |
Superoxide dismutase and allopurinol improve survival in an animal model of hemorrhagic shock.
Topics: Allopurinol; Animals; Catalase; Deferoxamine; Drug Therapy, Combination; Isotonic Solutions; Male; M | 1993 |
[Deferoxamine-conjugated hydroxyethyl starch reduces reperfusion injury to the liver following hemorrhagic shock].
Topics: Animals; Antioxidants; Blood Volume; Cell Adhesion; Chelating Agents; Deferoxamine; Female; Glutathi | 1997 |
Antioxidative resuscitation solution prevents leukocyte adhesion in the liver after hemorrhagic shock.
Topics: Animals; Antioxidants; Blood Flow Velocity; Cell Adhesion; Deferoxamine; Endothelium, Vascular; Flui | 1999 |
Starch-deferoxamine conjugate inhibits hepatocyte Ca2+ uptake during hemorrhagic shock and resuscitation.
Topics: Animals; Calcium; Deferoxamine; Disease Models, Animal; Hemodynamics; Hydroxyethyl Starch Derivative | 2000 |
Kupffer cells and neutrophils as paracrine regulators of the heme oxygenase-1 gene in hepatocytes after hemorrhagic shock.
Topics: Acetylcysteine; Animals; Antioxidants; Blood Pressure; Cells, Cultured; Chromans; Clodronic Acid; De | 2001 |
Deferoxamine and hespan complex as a resuscitative adjuvant in hemorrhagic shock rat model.
Topics: Animals; Deferoxamine; Hydroxyethyl Starch Derivatives; Iron Chelating Agents; Isotonic Solutions; L | 2002 |
Iron chelation with a deferoxamine conjugate in hemorrhagic shock.
Topics: Animals; Aspartate Aminotransferases; Chelating Agents; Deferoxamine; Hemodynamics; Hydroxyethyl Sta | 1991 |
Comparison of the efficacy of mechanistically different antioxidants in the rat hemorrhagic shock model.
Topics: Animals; Antioxidants; Chromans; Deferoxamine; Disease Models, Animal; Ibuprofen; Lipid Peroxidation | 1991 |
Myoglobin depletes renal adenine nucleotide pools in the presence and absence of shock.
Topics: Acute Kidney Injury; Adenine Nucleotides; Animals; Benzoates; Benzoic Acid; Deferoxamine; Female; He | 1991 |
Hemorrhagic shock-induced bacterial translocation: the role of neutrophils and hydroxyl radicals.
Topics: Animals; Bacterial Physiological Phenomena; Cell Movement; Deferoxamine; Dimethyl Sulfoxide; Free Ra | 1990 |
Evaluation of desferrioxamine mesylate on survival, and prevention of histopathological changes in the liver, in haemorrhagic shock: an experimental study in dogs.
Topics: Animals; Chelating Agents; Deferoxamine; Dogs; Female; Liver; Male; Shock, Hemorrhagic; Time Factors | 1989 |
Protection by desferrioxamine against histopathological changes of the liver in the post-oligaemic phase of clinical haemorrhagic shock in dogs: correlation with improved survival rate and recovery.
Topics: Animals; Deferoxamine; Dogs; Female; Liver; Male; Reference Values; Shock, Hemorrhagic | 1989 |
Effect of desferrioxamine mesylate (Desferal) in anaesthetized dogs with clinical haemorrhagic shock.
Topics: Animals; Blood Pressure; Deferoxamine; Dogs; Female; Male; Shock, Hemorrhagic | 1986 |