deferoxamine has been researched along with Hemolysis in 31 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Hemolysis: The destruction of ERYTHROCYTES by many different causal agents such as antibodies, bacteria, chemicals, temperature, and changes in tonicity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Several vanadium compounds were tested for their ability to induce in vitro hemolysis of vitamin E-deficient hamster erythrocytes." | 7.69 | Vanadium induced hemolysis of vitamin E deficient erythrocytes in Hepes buffer. ( Hamada, T, 1994) |
| "These results indicate that membrane attack complex and erythrophagocytosis contribute to hematoma clearance after ICH, which can be altered by deferoxamine treatment." | 3.83 | Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage. ( Cao, S; Chen, G; Hua, Y; Keep, RF; Xi, G; Zheng, M, 2016) |
| "Several vanadium compounds were tested for their ability to induce in vitro hemolysis of vitamin E-deficient hamster erythrocytes." | 3.69 | Vanadium induced hemolysis of vitamin E deficient erythrocytes in Hepes buffer. ( Hamada, T, 1994) |
| "Since hemolysis is a result of hemin association with the membrane components, its binding in the presence and absence of DFO was studied." | 1.28 | Desferrioxamine protects human red blood cells from hemin-induced hemolysis. ( Baysal, E; Monteiro, HP; Stern, A; Sullivan, SG, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 14 (45.16) | 18.7374 |
| 1990's | 10 (32.26) | 18.2507 |
| 2000's | 3 (9.68) | 29.6817 |
| 2010's | 4 (12.90) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gelosa, P | 1 |
| Pignieri, A | 1 |
| Gianazza, E | 1 |
| Criniti, S | 1 |
| Guerrini, U | 1 |
| Cappellini, MD | 1 |
| Banfi, C | 1 |
| Tremoli, E | 1 |
| Sironi, L | 1 |
| Imran ul-haq, M | 1 |
| Hamilton, JL | 1 |
| Lai, BF | 1 |
| Shenoi, RA | 1 |
| Horte, S | 1 |
| Constantinescu, I | 1 |
| Leitch, HA | 1 |
| Kizhakkedathu, JN | 2 |
| Gao, C | 1 |
| Du, H | 1 |
| Hua, Y | 2 |
| Keep, RF | 2 |
| Strahle, J | 1 |
| Xi, G | 2 |
| Cao, S | 1 |
| Zheng, M | 1 |
| Chen, G | 1 |
| Rossi, NA | 1 |
| Mustafa, I | 1 |
| Jackson, JK | 1 |
| Burt, HM | 1 |
| Horte, SA | 1 |
| Scott, MD | 1 |
| Casado, MF | 1 |
| Cecchini, AL | 1 |
| Simão, AN | 1 |
| Oliveira, RD | 1 |
| Cecchini, R | 1 |
| Scuro, LA | 1 |
| Dobrilla, G | 1 |
| Clark, IA | 3 |
| Cowden, WB | 2 |
| Hunt, NH | 3 |
| Maxwell, LE | 2 |
| Mackie, EJ | 2 |
| Hamada, T | 1 |
| Kljuchnikov, S | 1 |
| Pitkänen, O | 1 |
| Raivio, KO | 1 |
| Andersson, S | 1 |
| Jurado, RL | 1 |
| Santamaría, A | 1 |
| Sánchez-Rodríguez, J | 1 |
| Zugasti, A | 1 |
| Martínez, A | 1 |
| Galván-Arzate, S | 1 |
| Segura-Puertas, L | 1 |
| Mey, U | 1 |
| Sullivan, SG | 2 |
| Baysal, E | 2 |
| Stern, A | 2 |
| Ferrali, M | 2 |
| Signorini, C | 2 |
| Ciccoli, L | 2 |
| Comporti, M | 2 |
| Vanella, A | 1 |
| Campisi, A | 1 |
| Castorina, C | 1 |
| Sorrenti, V | 1 |
| Attaguile, G | 1 |
| Samperi, P | 1 |
| Azzia, N | 1 |
| Di Giacomo, C | 1 |
| Schilirò, G | 1 |
| Vissers, MC | 1 |
| Fantone, JC | 1 |
| Monteiro, HP | 1 |
| Hellwig, U | 1 |
| Khalifa, AS | 1 |
| el-Alfy, MS | 1 |
| Mokhtar, G | 1 |
| Fakeir, AA | 1 |
| Khazbak, MA | 1 |
| el-Baz, F | 1 |
| el-Kholy, M | 1 |
| Einsele, H | 1 |
| Clemens, MR | 1 |
| Wegner, U | 1 |
| Waller, HD | 1 |
| Ekert, H | 1 |
| Rawlinson, I | 1 |
| Cumming, RL | 1 |
| Goldberg, A | 1 |
| Morrow, J | 1 |
| Smith, JA | 1 |
| Eriksson, F | 1 |
| Johansson, SV | 1 |
| Mellstedt, H | 1 |
| Stranberg, O | 1 |
| Wester, PO | 1 |
| Turnbull, A | 1 |
| Hedenberg, L | 2 |
| Hallberg, L | 1 |
| Walsh, JR | 1 |
| Brodeur, MT | 1 |
| Ritzmann, LW | 1 |
| Sutherland, DW | 1 |
| Starr, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety of Surgical Treatment In Severe Primary Pontine Hemorrhage Evacuation (STIPE): a Multicentric, Randomized, Controlled, Open-label Trial[NCT04647162] | 64 participants (Anticipated) | Interventional | 2022-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for deferoxamine and Hemolysis
| Article | Year |
|---|---|
Iron, infections, and anemia of inflammation.
Topics: Anemia; Bacteria; Bacterial Infections; Blood Transfusion; Carrier Proteins; Conalbumin; Deferoxamin | 1997 |
[Foundations of the diagnosis and therapy of hemolytic anemias].
Topics: Agglutinins; Anemia, Hemolytic; Antigens; Autoimmune Diseases; Blood Protein Disorders; Blood Transf | 1978 |
Iron metabolism in the porphyrias.
Topics: Alcohol Drinking; Amino Acids; Anemia, Hemolytic; Bloodletting; Bone Marrow; Bone Marrow Diseases; D | 1971 |
1 trial available for deferoxamine and Hemolysis
| Article | Year |
|---|---|
Effect of desferrioxamine B on hemolysis in glucose-6-phosphate dehydrogenase deficiency.
Topics: Child, Preschool; Deferoxamine; Female; Glucosephosphate Dehydrogenase Deficiency; Hemoglobins; Hemo | 1989 |
27 other studies available for deferoxamine and Hemolysis
| Article | Year |
|---|---|
Altered iron homeostasis in an animal model of hypertensive nephropathy: stroke-prone rats.
Topics: Animals; Blood Pressure; Deferoxamine; Disease Models, Animal; Hemolysis; Homeostasis; Hypertension, | 2013 |
Design of long circulating nontoxic dendritic polymers for the removal of iron in vivo.
Topics: Animals; Biocompatible Materials; Cell Survival; Chelating Agents; Complement Activation; Deferoxami | 2013 |
Role of red blood cell lysis and iron in hydrocephalus after intraventricular hemorrhage.
Topics: Animals; Cerebral Hemorrhage; Deferoxamine; Erythrocytes; Ferritins; Heme Oxygenase-1; Hemolysis; Hy | 2014 |
Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage.
Topics: Animals; Complement Membrane Attack Complex; Deferoxamine; Disease Models, Animal; Hematoma; Hemolys | 2016 |
In vitro chelating, cytotoxicity, and blood compatibility of degradable poly(ethylene glycol)-based macromolecular iron chelators.
Topics: Biocompatible Materials; Blood Coagulation; Catalysis; Cell Death; Cell Survival; Complement Activat | 2009 |
Free radical-mediated pre-hemolytic injury in human red blood cells subjected to lead acetate as evaluated by chemiluminescence.
Topics: Antioxidants; Chromans; Deferoxamine; Erythrocyte Membrane; Erythrocytes; Formates; Free Radicals; G | 2007 |
Siderosis, haemolysis or hepatonecrosis in increasing post-desferrioxamine sideruria in acute viral hepatitis?
Topics: Deferoxamine; Hemolysis; Hepatitis A; Humans; Iron; Liver Diseases; Necrosis; Siderosis | 1967 |
Activity of divicine in Plasmodium vinckei-infected mice has implications for treatment of favism and epidemiology of G-6-PD deficiency.
Topics: Animals; Deferoxamine; Erythrocytes; Favism; Female; Glucosephosphate Dehydrogenase Deficiency; Glut | 1984 |
Radical-mediated damage to parasites and erythrocytes in Plasmodium vinckei infected mice after injection of t-butyl hydroperoxide.
Topics: Animals; Deferoxamine; Erythrocytes; Female; Free Radicals; Glutathione; Hemolysis; Malaria; Male; M | 1984 |
Evidence for reactive oxygen intermediates causing hemolysis and parasite death in malaria.
Topics: Alloxan; Animals; Deferoxamine; Erythrocytes; Female; Free Radicals; Hemolysis; Hydrogen Peroxide; M | 1983 |
Vanadium induced hemolysis of vitamin E deficient erythrocytes in Hepes buffer.
Topics: Analysis of Variance; Animals; Chelating Agents; Cricetinae; Deferoxamine; Erythrocytes; Free Radica | 1994 |
Haemolysis in adult and neonatal erythrocytes caused by autoxidation of lipid emulsion (Intralipid).
Topics: Adult; Deferoxamine; Erythrocytes; Etidronic Acid; Fat Emulsions, Intravenous; Free Radicals; Glutat | 1993 |
A venom extract from the sea anemone Bartholomea annulata produces haemolysis and lipid peroxidation in mouse erythrocytes.
Topics: Animals; Antioxidants; Cnidarian Venoms; Deferoxamine; Dose-Response Relationship, Drug; Erythrocyte | 2002 |
Inhibition of hemin-induced hemolysis by desferrioxamine: binding of hemin to red cell membranes and the effects of alteration of membrane sulfhydryl groups.
Topics: Deferoxamine; Diamide; Erythrocyte Membrane; Ethylmaleimide; Glutathione; Hemin; Hemolysis; Humans; | 1992 |
Iron release and membrane damage in erythrocytes exposed to oxidizing agents, phenylhydrazine, divicine and isouramil.
Topics: Animals; Barbiturates; Deferoxamine; Erythrocyte Membrane; Glutathione; Hemolysis; Iron; Lipid Perox | 1992 |
Antioxidant enzymatic systems and oxidative stress in erythrocytes with G6PD deficiency: effect of deferoxamine.
Topics: Adult; Catalase; Deferoxamine; Erythrocytes; Glucosephosphate Dehydrogenase Deficiency; Glutathione | 1991 |
Inhibition of hypochlorous acid-mediated reactions by desferrioxamine. Implications for the mechanism of cellular injury by neutrophils.
Topics: Chloramines; Deferoxamine; Erythrocyte Membrane; Free Radicals; Hemoglobins; Hemolysis; Humans; Hypo | 1990 |
Desferrioxamine protects human red blood cells from hemin-induced hemolysis.
Topics: Deferoxamine; Erythrocyte Membrane; Free Radicals; Hemin; Hemolysis; Humans; Spectrophotometry | 1990 |
Iron release and erythrocyte damage in allyl alcohol intoxication in mice.
Topics: 1-Propanol; Acrolein; Alcoholic Intoxication; Animals; Deferoxamine; Erythrocytes; Hemoglobins; Hemo | 1990 |
Factors influencing the formation of methemoglobin in desferrioxamine loaded erythrocytes.
Topics: 2,3-Diphosphoglycerate; Deferoxamine; Diphosphoglyceric Acids; Erythrocytes; Hemolysis; Humans; Kine | 1990 |
Effect of free radical scavengers and metal ion chelators on hydrogen peroxide and phenylhydrazine induced red blood cell lipid peroxidation.
Topics: Alkanes; Antioxidants; Deferoxamine; Erythrocytes; Fatty Acids; Free Radicals; Hemolysis; Humans; Ma | 1987 |
Deferoxamine and favism.
Topics: Child; Deferoxamine; Favism; Hemolysis; Humans; Male | 1985 |
Effect of phenylhydrazine-induced haemolysis on the urinary excretion of iron after desferrioxamine.
Topics: Anemia, Sideroblastic; Animals; Biopsy; Bone Marrow Examination; Deferoxamine; Feces; Guinea Pigs; H | 1967 |
Iron intoxication in two adult patients.
Topics: Adult; Deferoxamine; Female; Hemoglobins; Hemolysis; Humans; Hypotension; Iron; Jaundice; Liver Func | 1974 |
Studies on iron metabolism with desferrioxamine in man. Experimental and clinical studies.
Topics: Adult; Aged; Allopurinol; Anemia, Hypochromic; Blood Transfusion; Deferoxamine; Diet; Erythrocytes; | 1969 |
The effect of desferrioxamine on iron metabolism in man. II.
Topics: Deferoxamine; Hemolysis; Humans; Iron; Nicotinic Acids; Urine | 1965 |
Urinary iron excretion in patients with prosthetic heart valves.
Topics: Anemia, Hemolytic; Blood Transfusion; Chromium Isotopes; Deferoxamine; Erythrocytes; Heart Valve Pro | 1966 |