deferoxamine has been researched along with Heart Disease, Ischemic in 18 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with deferoxamine (10 mg/kg, n = 7) or dimethylthiourea (10 mg/kg, n = 6) decreased net production of HO." | 5.29 | Hydroxyl radical production during myocardial ischemia and reperfusion in cats. ( Fu, LW; Halliwell, B; Longhurst, JC; O'Neill, CA, 1996) |
| " Two studies were conducted to assess the efficacy of the complexes of desferrioxamine with zinc or gallium to prevent this aspect of reperfusion injury." | 3.71 | The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection. ( Berenshtein, E; Chevion, M; Haverich, A; Karck, M; Sturm, C; Tanaka, S, 2001) |
| "Pretreatment with deferoxamine (10 mg/kg, n = 7) or dimethylthiourea (10 mg/kg, n = 6) decreased net production of HO." | 1.29 | Hydroxyl radical production during myocardial ischemia and reperfusion in cats. ( Fu, LW; Halliwell, B; Longhurst, JC; O'Neill, CA, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 14 (77.78) | 18.2507 |
| 2000's | 2 (11.11) | 29.6817 |
| 2010's | 1 (5.56) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
| Authors | Studies |
|---|---|
| Zheng, H | 1 |
| You, J | 1 |
| Yao, X | 1 |
| Lu, Q | 1 |
| Guo, W | 1 |
| Shen, Y | 1 |
| Yuan, C | 1 |
| Wang, H | 1 |
| Yuan, Z | 1 |
| Huang, HS | 1 |
| Pan, HL | 1 |
| Stahl, GL | 1 |
| Longhurst, JC | 2 |
| Eicher, JC | 1 |
| Gabrielle, F | 1 |
| Abadie, C | 1 |
| Maupoil, V | 1 |
| Wolf, JE | 1 |
| David, M | 1 |
| Rochette, L | 1 |
| Euler, DE | 1 |
| Voogd, A | 2 |
| Sluiter, W | 2 |
| Koster, JF | 2 |
| Ustinova, EE | 2 |
| Schultz, HD | 2 |
| Watanabe, BI | 1 |
| Limm, W | 1 |
| Suehiro, A | 1 |
| Suehiro, G | 1 |
| Premaratne, S | 1 |
| McNamara, JJ | 1 |
| Pucheu, S | 1 |
| Coudray, C | 1 |
| Tresallet, N | 1 |
| Favier, A | 1 |
| de Leiris, J | 1 |
| Hedlund, BE | 1 |
| Hallaway, PE | 1 |
| Sekili, S | 1 |
| McCay, PB | 1 |
| Li, XY | 1 |
| Zughaib, M | 1 |
| Sun, JZ | 1 |
| Tang, L | 1 |
| Thornby, JI | 1 |
| Bolli, R | 1 |
| O'Neill, CA | 1 |
| Fu, LW | 1 |
| Halliwell, B | 1 |
| Shadid, M | 1 |
| Van Bel, F | 1 |
| Steendijk, P | 1 |
| Dorrepaal, CA | 1 |
| Moison, R | 1 |
| Van Der Velde, ET | 1 |
| Baan, J | 1 |
| Powell, SR | 1 |
| Gurzenda, EM | 1 |
| Wingertzahn, MA | 1 |
| Wapnir, RA | 1 |
| Karck, M | 1 |
| Tanaka, S | 1 |
| Berenshtein, E | 1 |
| Sturm, C | 1 |
| Haverich, A | 1 |
| Chevion, M | 1 |
| Sullivan, JL | 1 |
| van Eijk, HG | 1 |
1 review available for deferoxamine and Heart Disease, Ischemic
| Article | Year |
|---|---|
High-dose systemic iron chelation attenuates reperfusion injury.
Topics: Animals; Deferoxamine; Dogs; Iron; Iron Chelating Agents; Myocardial Ischemia; Myocardial Reperfusio | 1993 |
17 other studies available for deferoxamine and Heart Disease, Ischemic
| Article | Year |
|---|---|
Superparamagnetic iron oxide nanoparticles promote ferroptosis of ischemic cardiomyocytes.
Topics: Adenosine Triphosphate; Animals; ATP-Binding Cassette Transporters; Autophagy; Deferoxamine; Endopla | 2020 |
Ginsenoside Rg1 inhibits myocardial ischaemia and reperfusion injury
Topics: Animals; Apoptosis; Caspase 3; Caspase 9; Deferoxamine; Diabetes Mellitus, Experimental; Extracellul | 2019 |
Ischemia- and reperfusion-sensitive cardiac sympathetic afferents: influence of H2O2 and hydroxyl radicals.
Topics: Animals; Bradykinin; Cats; Deferoxamine; Female; Free Radical Scavengers; Heart Conduction System; H | 1995 |
Experimental preservation of the heart transplant: effects of deferoxamine on functional recovery and lipid peroxidation of the isolated-perfused rat heart subjected to ischemia and reperfusion.
Topics: Animals; Deferoxamine; Heart; In Vitro Techniques; Lipid Peroxidation; Male; Malondialdehyde; Myocar | 1995 |
Role of oxygen-derived free radicals in canine reperfusion arrhythmias.
Topics: Animals; Antioxidants; Arrhythmias, Cardiac; Blood Pressure; Catalase; Coronary Circulation; Coronar | 1995 |
The increased susceptibility to hydrogen peroxide of the (post-)ischemic rat heart is associated with the magnitude of the low molecular weight iron pool.
Topics: Animals; Catalase; Deferoxamine; Glutathione; Glutathione Disulfide; Glutathione Peroxidase; Heart; | 1994 |
Activation of cardiac vagal afferents in ischemia and reperfusion. Prostaglandins versus oxygen-derived free radicals.
Topics: Afferent Pathways; Animals; Deferoxamine; Female; Heart; Hydrogen Peroxide; Indomethacin; Male; Myoc | 1994 |
Failure of deferoxamine to reduce myocardial infarct size in a primate model of ischemia-reperfusion injury.
Topics: Animals; Deferoxamine; Disease Models, Animal; Electrocardiography; Female; Free Radicals; Hydroxyl | 1993 |
Effect of iron overload in the isolated ischemic and reperfused rat heart.
Topics: Animals; Blood Pressure; Catalase; Deferoxamine; Female; Freezing; Glutathione Peroxidase; Heart Rat | 1993 |
Direct evidence that the hydroxyl radical plays a pathogenetic role in myocardial "stunning" in the conscious dog and demonstration that stunning can be markedly attenuated without subsequent adverse effects.
Topics: Animals; Coronary Circulation; Deferoxamine; Dogs; Female; Hemodynamics; Hydroxides; Hydroxyl Radica | 1993 |
Hydroxyl radical production during myocardial ischemia and reperfusion in cats.
Topics: Animals; Cats; Deferoxamine; Female; Free Radical Scavengers; Heart Ventricles; Hydroxyl Radical; La | 1996 |
Renal sympathetic nerve activity during cardiac ischemia and reperfusion in rats.
Topics: Administration, Topical; Animals; Blood Pressure; Capsaicin; Deferoxamine; Denervation; Heart Conduc | 1996 |
Effect of deferoxamine on post-hypoxic-ischemic reperfusion injury of the newborn lamb heart.
Topics: Animals; Animals, Newborn; Ascorbic Acid; Chelating Agents; Deferoxamine; Dehydroascorbic Acid; Fema | 1999 |
Promotion of copper excretion from the isolated rat heart attenuates postischemic cardiac oxidative injury.
Topics: Animals; Antidotes; Chelating Agents; Copper; Deferoxamine; Histidine; Male; Myocardial Ischemia; My | 1999 |
The push-and-pull mechanism to scavenge redox-active transition metals: a novel concept in myocardial protection.
Topics: Analysis of Variance; Animals; Cardioplegic Solutions; Deferoxamine; Disease Models, Animal; Drug Sy | 2001 |
Stored iron and myocardial perfusion deficits.
Topics: Animals; Coronary Artery Disease; Deferoxamine; Ferritins; Humans; Hypercholesterolemia; Iron; Iron | 2002 |
Low molecular weight iron and the oxygen paradox in isolated rat hearts.
Topics: Animals; Deferoxamine; Free Radicals; Hypoxia; In Vitro Techniques; Iron; Male; Molecular Weight; My | 1992 |