deferoxamine has been researched along with Gram-Negative Bacterial Infections in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Gram-Negative Bacterial Infections: Infections caused by bacteria that show up as pink (negative) when treated by the gram-staining method.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as deferoxamine (DFO)." | 7.75 | Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients. ( Chan, GC; Chan, S; Ha, SY; Ho, PL, 2009) |
| "5 g twice weekly for aluminum bone disease developed fever and bilateral calf pain caused by myonecrosis with gas gangrene." | 7.69 | Fatal Aeromonas hydrophila bacteremia in a hemodialysis patient treated with deferoxamine. ( Boelaert, JR; De Brauwer, E; Gordts, B; Lin, SH; Lin, YF; Shieh, SD; Van Landuyt, HW, 1996) |
| " We conclude that iron-chelation therapy with DFO at the above dosage results in a significant deterioration in cardiovascular function in septic swine." | 5.29 | Deferoxamine induces hypotension in experimental gram-negative septicemia. ( Bohnen, JM; Mullen, JB; Mustard, RA; Schouten, BD; Swanson, HT, 1994) |
| " The known predisposing factors of infection include prior splenectomy, iron overload and use of iron chelator such as deferoxamine (DFO)." | 3.75 | Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients. ( Chan, GC; Chan, S; Ha, SY; Ho, PL, 2009) |
| "5 g twice weekly for aluminum bone disease developed fever and bilateral calf pain caused by myonecrosis with gas gangrene." | 3.69 | Fatal Aeromonas hydrophila bacteremia in a hemodialysis patient treated with deferoxamine. ( Boelaert, JR; De Brauwer, E; Gordts, B; Lin, SH; Lin, YF; Shieh, SD; Van Landuyt, HW, 1996) |
| " We conclude that iron-chelation therapy with DFO at the above dosage results in a significant deterioration in cardiovascular function in septic swine." | 1.29 | Deferoxamine induces hypotension in experimental gram-negative septicemia. ( Bohnen, JM; Mullen, JB; Mustard, RA; Schouten, BD; Swanson, HT, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (33.33) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 1 (16.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chan, GC | 1 |
| Chan, S | 1 |
| Ho, PL | 1 |
| Ha, SY | 1 |
| Ryan, MP | 1 |
| Pembroke, JT | 1 |
| Adley, CC | 1 |
| Daxboeck, F | 1 |
| Stadler, M | 1 |
| Assadian, O | 1 |
| Marko, E | 1 |
| Hirschl, AM | 1 |
| Koller, W | 1 |
| Mustard, RA | 1 |
| Bohnen, JM | 1 |
| Mullen, JB | 1 |
| Schouten, BD | 1 |
| Swanson, HT | 1 |
| Lin, SH | 1 |
| Shieh, SD | 1 |
| Lin, YF | 1 |
| De Brauwer, E | 1 |
| Van Landuyt, HW | 1 |
| Gordts, B | 1 |
| Boelaert, JR | 1 |
| Ghosh, K | 1 |
| Daar, S | 1 |
| Hiwase, D | 1 |
| Nursat, N | 1 |
6 other studies available for deferoxamine and Gram-Negative Bacterial Infections
| Article | Year |
|---|---|
Effects of chelators (deferoxamine, deferiprone and deferasirox) on the growth of Klebsiella pneumoniae and Aeromonas hydrophila isolated from transfusion-dependent thalassemia patients.
Topics: Aeromonas hydrophila; Benzoates; Blood Transfusion; Deferasirox; Deferiprone; Deferoxamine; Gram-Neg | 2009 |
Differentiating the growing nosocomial infectious threats Ralstonia pickettii and Ralstonia insidiosa.
Topics: Acetylglucosamine; Anti-Bacterial Agents; Arabinose; Bacterial Typing Techniques; Cross Infection; D | 2011 |
Characterization of clinically isolated Ralstonia mannitolilytica strains using random amplification of polymorphic DNA (RAPD) typing and antimicrobial sensitivity, and comparison of the classification efficacy of phenotypic and genotypic assays.
Topics: Adult; Aged; Anti-Bacterial Agents; Austria; Bacterial Typing Techniques; Carboxylic Acids; Culture | 2005 |
Deferoxamine induces hypotension in experimental gram-negative septicemia.
Topics: Animals; Deferoxamine; Disease Models, Animal; Gram-Negative Bacterial Infections; Hemodynamics; Hyp | 1994 |
Fatal Aeromonas hydrophila bacteremia in a hemodialysis patient treated with deferoxamine.
Topics: Aeromonas hydrophila; Aluminum; Antidotes; Bacteremia; Bone Diseases; Deferoxamine; Fatal Outcome; F | 1996 |
Primary pseudomonas meningitis in an adult, splenectomized, multitransfused thalassaemia major patient.
Topics: Adolescent; Adult; Aged; beta-Thalassemia; Blood Transfusion; Chelating Agents; Chelation Therapy; C | 2000 |