deferoxamine has been researched along with Glioma in 13 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 7.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| " 5-aminolevulinic acid (ALA) is metabolized to fluorescent protoporphyrin IX (PpIX) specifically in tumor cells, and therefore clinically used as a reagent for photodynamic diagnosis (PDD) and therapy (PDT) of cancers including gliomas." | 3.85 | Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation. ( Hagiya, Y; Kokubu, Y; Murota, Y; Ogura, SI; Sugiyama, Y; Tabu, K; Taga, T; Wang, W, 2017) |
| " We found dihydroartemisinin (5-25 microM) inhibited the growth and induced apoptosis of C6 cells in a concentration- and time-dependent manner; however, it was much less toxic to rat primary astrocytes." | 1.34 | Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells. ( Huang, XJ; Lu, YB; Ma, ZQ; Wei, EQ; Zhang, WP, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (38.46) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 3 (23.08) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lo Dico, A | 1 |
| Valtorta, S | 1 |
| Martelli, C | 1 |
| Belloli, S | 1 |
| Gianelli, U | 1 |
| Tosi, D | 1 |
| Bosari, S | 1 |
| Degrassi, A | 1 |
| Russo, M | 1 |
| Raccagni, I | 1 |
| Lucignani, G | 1 |
| Moresco, RM | 1 |
| Ottobrini, L | 1 |
| Ivanov, SD | 1 |
| Semenov, AL | 1 |
| Kovan'ko, EG | 1 |
| Yamshanov, VA | 1 |
| Wang, W | 1 |
| Tabu, K | 1 |
| Hagiya, Y | 1 |
| Sugiyama, Y | 1 |
| Kokubu, Y | 1 |
| Murota, Y | 1 |
| Ogura, SI | 1 |
| Taga, T | 1 |
| Lu, H | 1 |
| Li, Y | 1 |
| Shu, M | 1 |
| Tang, J | 1 |
| Huang, Y | 1 |
| Zhou, Y | 1 |
| Liang, Y | 1 |
| Yan, G | 1 |
| Yang, DI | 1 |
| Chen, SD | 1 |
| Yang, YT | 1 |
| Ju, TC | 1 |
| Xu, JM | 1 |
| Hsu, CY | 1 |
| Huang, XJ | 1 |
| Ma, ZQ | 1 |
| Zhang, WP | 1 |
| Lu, YB | 1 |
| Wei, EQ | 1 |
| Brodie, C | 1 |
| Siriwardana, G | 1 |
| Lucas, J | 1 |
| Schleicher, R | 1 |
| Terada, N | 1 |
| Szepesi, A | 1 |
| Gelfand, E | 1 |
| Seligman, P | 1 |
| Renton, FJ | 1 |
| Jeitner, TM | 1 |
| Philipov, P | 1 |
| Tsai, KL | 1 |
| Wang, SM | 1 |
| Chen, CC | 1 |
| Fong, TH | 1 |
| Wu, ML | 1 |
| Higuchi, Y | 1 |
| Matsukawa, S | 1 |
| Amoroso, S | 1 |
| Tortiglione, A | 1 |
| Secondo, A | 1 |
| Catalano, A | 1 |
| Montagnani, S | 1 |
| Di Renzo, G | 1 |
| Annunziato, L | 1 |
| Tjalkens, RB | 1 |
| Ewing, MM | 1 |
| Philbert, MA | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metformin and Neo-adjuvant Temozolomide and Hypofractionated Accelerated Limited-margin Radiotherapy Followed by Adjuvant Temozolomide in Patients With Glioblastoma Multiforme (M-HARTT STUDY)[NCT02780024] | Phase 2 | 50 participants (Anticipated) | Interventional | 2015-03-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
13 other studies available for deferoxamine and Glioma
| Article | Year |
|---|---|
Validation of an engineered cell model for in vitro and in vivo HIF-1α evaluation by different imaging modalities.
Topics: Animals; Brain Neoplasms; Cell Hypoxia; Cell Line, Tumor; Cell Shape; Deferoxamine; Glioma; Humans; | 2014 |
Effects of iron ions and iron chelation on the efficiency of experimental radiotherapy of animals with gliomas.
Topics: Animals; Deferoxamine; Glioma; Iron; Male; Radiotherapy; Rats; Rats, Wistar | 2015 |
Enhancement of 5-aminolevulinic acid-based fluorescence detection of side population-defined glioma stem cells by iron chelation.
Topics: Aminolevulinic Acid; Animals; ATP Binding Cassette Transporter, Subfamily G, Member 2; Biotransforma | 2017 |
Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Cobalt; Colforsin; | 2009 |
Carbamoylating chemoresistance induced by cobalt pretreatment in C6 glioma cells: putative roles of hypoxia-inducible factor-1.
Topics: Animals; Antineoplastic Agents, Alkylating; Carmustine; Cell Line, Tumor; Cell Survival; Cobalt; Def | 2004 |
Dihydroartemisinin exerts cytotoxic effects and inhibits hypoxia inducible factor-1alpha activation in C6 glioma cells.
Topics: Animals; Antineoplastic Agents; Apoptosis; Artemisinins; Cell Hypoxia; Cell Proliferation; Cell Surv | 2007 |
Neuroblastoma sensitivity to growth inhibition by deferrioxamine: evidence for a block in G1 phase of the cell cycle.
Topics: Aphidicolin; Cell Count; Cell Division; Deferoxamine; Drug Screening Assays, Antitumor; Ferritins; G | 1993 |
Cell cycle-dependent inhibition of the proliferation of human neural tumor cell lines by iron chelators.
Topics: Antineoplastic Agents; Cell Cycle; Cell Division; Deferoxamine; Glioma; Humans; Iron Chelating Agent | 1996 |
Suppression of tumor growth in experimental 9L gliosarcoma model by copper depletion.
Topics: Brain Neoplasms; Chelating Agents; Deferoxamine; Glioma; Humans; Penicillamine; Trace Elements | 1996 |
Mechanism of oxidative stress-induced intracellular acidosis in rat cerebellar astrocytes and C6 glioma cells.
Topics: Acidosis; Adenosine Triphosphate; Animals; Astrocytes; Catalase; Cells, Cultured; Cerebellum; Citric | 1997 |
Active oxygen-mediated chromosomal 1-2 Mbp giant DNA fragmentation into internucleosomal DNA fragmentation in apoptosis of glioma cells induced by glutamate.
Topics: Acetylcysteine; Animals; Antioxidants; Apoptosis; Ascorbic Acid; Catalase; Chromosomes; Deferoxamine | 1998 |
Sodium nitroprusside prevents chemical hypoxia-induced cell death through iron ions stimulating the activity of the Na+-Ca2+ exchanger in C6 glioma cells.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Amiloride; Animals; Bepridil; Calcium; Calcium Channel Block | 2000 |
Differential cellular regulation of the mitochondrial permeability transition in an in vitro model of 1,3-dinitrobenzene-induced encephalopathy.
Topics: Adenosine Triphosphate; Antioxidants; bcl-2-Associated X Protein; bcl-X Protein; Brain Diseases; Cal | 2000 |