deferoxamine has been researched along with Friedreich Disease in 4 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Alldredge, CD | 1 |
| Schlieve, CR | 1 |
| Miller, NR | 1 |
| Levin, LA | 1 |
| Li, K | 1 |
| Besse, EK | 1 |
| Ha, D | 1 |
| Kovtunovych, G | 1 |
| Rouault, TA | 1 |
| Wong, A | 1 |
| Yang, J | 1 |
| Cavadini, P | 1 |
| Gellera, C | 1 |
| Lonnerdal, B | 1 |
| Taroni, F | 1 |
| Cortopassi, G | 1 |
| Rustin, P | 1 |
| Munnich, A | 1 |
| Rötig, A | 1 |
4 other studies available for deferoxamine and Friedreich Disease
| Article | Year |
|---|---|
Pathophysiology of the optic neuropathy associated with Friedreich ataxia.
Topics: Animals; Animals, Newborn; Anisoles; Cell Death; Cells, Cultured; Chlorides; Deferoxamine; Ferric Co | 2003 |
Iron-dependent regulation of frataxin expression: implications for treatment of Friedreich ataxia.
Topics: Cell Line; Cytosol; Deferoxamine; Fibroblasts; Frataxin; Friedreich Ataxia; Gene Expression Regulati | 2008 |
The Friedreich's ataxia mutation confers cellular sensitivity to oxidant stress which is rescued by chelators of iron and calcium and inhibitors of apoptosis.
Topics: Apoptosis; Base Sequence; Calcium; Case-Control Studies; Caspase 3; Caspases; Cell Line; Chelating A | 1999 |
Quinone analogs prevent enzymes targeted in Friedreich ataxia from iron-induced injury in vitro.
Topics: Aconitate Hydratase; Benzoquinones; Coenzymes; Deferoxamine; Electron Transport Complex II; Friedrei | 1999 |