deferoxamine has been researched along with Experimental Leukemia in 5 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Deferoxamine (DFO) is an iron chelator that is known to inhibit acute non-lymphocytic leukemia cells in vitro." | 5.28 | Failure to alter the course of acute myelogenous leukemia in the rat with subcutaneous deferoxamine. ( Arena, VC; Blatt, J; Boegel, F; Hedlund, BE; Shadduck, RK, 1991) |
| "Deferoxamine (DFO) is an iron chelator that is known to inhibit acute non-lymphocytic leukemia cells in vitro." | 1.28 | Failure to alter the course of acute myelogenous leukemia in the rat with subcutaneous deferoxamine. ( Arena, VC; Blatt, J; Boegel, F; Hedlund, BE; Shadduck, RK, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 3 (60.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Heath, JL | 1 |
| Weiss, JM | 1 |
| Lavau, CP | 1 |
| Wechsler, DS | 1 |
| Hoyes, KP | 1 |
| Porter, JB | 1 |
| Coccia, EM | 1 |
| Perrotti, E | 1 |
| Stellacci, E | 1 |
| Orsatti, R | 1 |
| Del Russo, N | 1 |
| Marziali, G | 1 |
| Testa, U | 1 |
| Battistini, A | 1 |
| Blatt, J | 1 |
| Boegel, F | 1 |
| Hedlund, BE | 1 |
| Arena, VC | 1 |
| Shadduck, RK | 1 |
| Bomford, A | 1 |
| Isaac, J | 1 |
| Roberts, S | 1 |
| Edwards, A | 1 |
| Young, S | 1 |
| Williams, R | 1 |
5 other studies available for deferoxamine and Experimental Leukemia
| Article | Year |
|---|---|
Effects of iron depletion on CALM-AF10 leukemias.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Benzoates; Biological Transport; Cell Line, | 2014 |
Subcellular distribution of desferrioxamine and hydroxypyridin-4-one chelators in K562 cells affects chelation of intracellular iron pools.
Topics: Cytosol; Deferoxamine; Humans; Iron; Iron Chelating Agents; Leukemia, Experimental; Molecular Weight | 1993 |
Regulation of expression of ferritin H-chain and transferrin receptor by protoporphyrin IX.
Topics: Animals; Cell Count; Chloramphenicol O-Acetyltransferase; Deferoxamine; Ferritins; Gene Expression R | 1997 |
Failure to alter the course of acute myelogenous leukemia in the rat with subcutaneous deferoxamine.
Topics: Animals; Deferoxamine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Injec | 1991 |
The effect of desferrioxamine on transferrin receptors, the cell cycle and growth rates of human leukaemic cells.
Topics: Cell Cycle; Cell Division; Cell Line; Deferoxamine; DNA; Ferric Compounds; Humans; Iron; Kinetics; L | 1986 |