deferoxamine has been researched along with Encephalopathy, Toxic in 11 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Factors such as brain penetrance and bioavailability have limited the advancement of potential antioxidant and iron chelator therapies for PD." | 1.56 | Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity. ( Mursaleen, L; Somavarapu, S; Zariwala, MG, 2020) |
| " Iron is an essential nutrient but high levels are toxic due to the catalytic generation of destructive hydroxyl radicals." | 1.43 | A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity. ( Cahill, CM; Jiang, H; Liu, Y; Rogers, JT; Smith, A; Tummala, V; Venkataramani, V; Washburn, C, 2016) |
| "Pre-treatment with deferoxamine or Trolox reduced the intensity of protein carbonylation in DI TNC1 cells exposed to 1mM 1,3-DNB." | 1.37 | Proteomic identification of carbonylated proteins in 1,3-dinitrobenzene neurotoxicity. ( Philbert, MA; Steiner, SR, 2011) |
| "The methadone solution was heated in an aluminum pot to reduce the volume and then injected intravenously (IV)." | 1.33 | Aluminum toxicity following IV use of oral methadone solution. ( Friesen, MS; Gair, RD; Purssell, RA, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (27.27) | 29.6817 |
| 2010's | 7 (63.64) | 24.3611 |
| 2020's | 1 (9.09) | 2.80 |
| Authors | Studies |
|---|---|
| Mursaleen, L | 1 |
| Somavarapu, S | 1 |
| Zariwala, MG | 1 |
| Chen-Roetling, J | 2 |
| Ma, SK | 1 |
| Cao, Y | 1 |
| Shah, A | 1 |
| Regan, RF | 2 |
| Kapoor, S | 1 |
| Rogers, JT | 1 |
| Venkataramani, V | 1 |
| Washburn, C | 1 |
| Liu, Y | 1 |
| Tummala, V | 1 |
| Jiang, H | 1 |
| Smith, A | 1 |
| Cahill, CM | 1 |
| Chen, L | 1 |
| Wu, Y | 1 |
| Li, X | 1 |
| Xie, W | 1 |
| Jankovic, J | 1 |
| Le, W | 1 |
| Pan, T | 1 |
| Steiner, SR | 1 |
| Philbert, MA | 1 |
| Zhang, L | 1 |
| Hu, R | 1 |
| Li, M | 1 |
| Li, F | 1 |
| Meng, H | 1 |
| Zhu, G | 1 |
| Lin, J | 1 |
| Feng, H | 1 |
| Haleagrahara, N | 1 |
| Siew, CJ | 1 |
| Ponnusamy, K | 1 |
| Friesen, MS | 1 |
| Purssell, RA | 1 |
| Gair, RD | 1 |
| Park, MJ | 1 |
| Lee, SK | 1 |
| Lim, MA | 1 |
| Chung, HS | 1 |
| Cho, SI | 1 |
| Jang, CG | 1 |
| Lee, SM | 1 |
11 other studies available for deferoxamine and Encephalopathy, Toxic
| Article | Year |
|---|---|
Deferoxamine and Curcumin Loaded Nanocarriers Protect Against Rotenone-Induced Neurotoxicity.
Topics: Antioxidants; Cell Line, Tumor; Curcumin; Deferoxamine; Humans; Iron Chelating Agents; Lipid Peroxid | 2020 |
Hemopexin increases the neurotoxicity of hemoglobin when haptoglobin is absent.
Topics: Animals; Antidotes; Cyclohexylamines; Deferoxamine; Female; Ferritins; Globins; Haptoglobins; Heme O | 2018 |
Deferoxamine: emerging, new neuro-protective benefits.
Topics: Animals; Brain Injuries; Deferoxamine; Iron; Male; Neurotoxicity Syndromes; Siderophores | 2013 |
A role for amyloid precursor protein translation to restore iron homeostasis and ameliorate lead (Pb) neurotoxicity.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Deferoxamine; Gene Expression Regulation; Homeost | 2016 |
Minocycline attenuates iron neurotoxicity in cortical cell cultures.
Topics: Animals; Cerebral Cortex; Cerebral Hemorrhage; Cytoprotection; Deferoxamine; Iron; Iron Chelating Ag | 2009 |
Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells.
Topics: Antidotes; Apoptosis; Apoptosis Regulatory Proteins; Autophagy; Beclin-1; Blotting, Western; Cell Li | 2010 |
Proteomic identification of carbonylated proteins in 1,3-dinitrobenzene neurotoxicity.
Topics: Animals; Antioxidants; Astrocytes; Cell Line; Chromans; Chromatography, Liquid; Cytosol; Deferoxamin | 2011 |
Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury.
Topics: Analysis of Variance; Animals; Apoferritins; Atrophy; Brain; Brain Injuries; Deferoxamine; Disease M | 2013 |
Effect of quercetin and desferrioxamine on 6-hydroxydopamine (6-OHDA) induced neurotoxicity in striatum of rats.
Topics: Animals; Behavior, Animal; Corpus Striatum; Deferoxamine; Disease Models, Animal; Dopamine; Drug The | 2013 |
Aluminum toxicity following IV use of oral methadone solution.
Topics: Adult; Aluminum; Chelating Agents; Deferoxamine; Humans; Injections, Intravenous; Male; Methadone; N | 2006 |
Effect of alpha-tocopherol and deferoxamine on methamphetamine-induced neurotoxicity.
Topics: alpha-Tocopherol; Analysis of Variance; Animals; Biogenic Monoamines; Body Temperature; Corpus Stria | 2006 |