deferoxamine has been researched along with Drug Overdose in 16 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Drug Overdose: Accidental or deliberate use of a medication or street drug in excess of normal dosage.
| Excerpt | Relevance | Reference |
|---|---|---|
| " He was treated with a unique deferoxamine dosage schedule (25 mg/kg/h for 12 h/d x 3 d), mechanical ventilation, Swan-Ganz catheter monitoring, dopamine/nitroprusside therapy, blood product, bicarbonate, electrolyte and volume replacement." | 5.29 | Survival after a severe iron poisoning treated with intermittent infusions of deferoxamine. ( Benson, B; Cheney, K; Gumbiner, C; Tenenbein, M, 1995) |
| "A controversial therapy in the management of acute iron poisoning is the oral administration of deferoxamine which purportedly complexes unabsorbed iron, exerts protection at the cellular level, and/or enhances the renal elimination of ingested iron." | 3.69 | Iron complexation with oral deferoxamine in a swine model. ( Dean, BS; Griffith, GR; Hines, RH; Krenzelok, EP; Oehme, FW, 1996) |
| "To determine whether leukocytosis, hyperglycemia, vomiting, and opacities in abdominal radiographs are indicators of a serum iron concentration of > 300 micrograms/dL in adult iron overdose patients, a retrospective medical record review was undertaken at a university medical center of all patients older than 12 years of age for whom clinical data were collected before deferoxamine therapy and within 6 hours of iron ingestion." | 3.69 | Leukocytosis, hyperglycemia, vomiting, and positive X-rays are not indicators of severity of iron overdose in adults. ( Palatnick, W; Tenenbein, M, 1996) |
| "Treatment with deferoxamine was prompt and followed by empiric N-acetylcysteine once liver injury was apparent." | 1.33 | Acute liver failure due to iron overdose in an adult. ( Daram, SR; Hayashi, PH, 2005) |
| "A 17-year-old patient with sickle cell-beta thalassemia undergoing treatment with home iron chelation therapy inadvertently received ten times the recommended dose of intravenous deferoxamine." | 1.32 | Acute renal failure following deferoxamine overdose. ( Flynn, JT; Levine, JE; Prasannan, L, 2003) |
| " He was treated with a unique deferoxamine dosage schedule (25 mg/kg/h for 12 h/d x 3 d), mechanical ventilation, Swan-Ganz catheter monitoring, dopamine/nitroprusside therapy, blood product, bicarbonate, electrolyte and volume replacement." | 1.29 | Survival after a severe iron poisoning treated with intermittent infusions of deferoxamine. ( Benson, B; Cheney, K; Gumbiner, C; Tenenbein, M, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (6.25) | 18.7374 |
| 1990's | 7 (43.75) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Pietra, V | 1 |
| Degrassi, S | 1 |
| Fusi-Schmidhauser, T | 1 |
| Sankar, J | 1 |
| Shukla, A | 1 |
| Khurana, R | 1 |
| Dubey, N | 1 |
| Prasannan, L | 1 |
| Flynn, JT | 1 |
| Levine, JE | 1 |
| De, BK | 1 |
| Roberts, WL | 2 |
| Li Volti, S | 1 |
| Maccarone, C | 1 |
| Li Volti, G | 1 |
| Romeo, MA | 1 |
| Daram, SR | 1 |
| Hayashi, PH | 1 |
| Atas, B | 1 |
| Caksen, H | 1 |
| Tuncer, O | 1 |
| Oner, AF | 1 |
| Kirimi, E | 1 |
| Akbayram, S | 1 |
| Lamarque, D | 1 |
| Whittle, BJ | 1 |
| Cheney, K | 1 |
| Gumbiner, C | 1 |
| Benson, B | 1 |
| Tenenbein, M | 2 |
| Dean, BS | 1 |
| Oehme, FW | 1 |
| Krenzelok, EP | 1 |
| Griffith, GR | 1 |
| Hines, RH | 1 |
| Palatnick, W | 1 |
| Smith, PT | 1 |
| Martin, WJ | 1 |
| Rainey, PM | 1 |
| Tran, T | 1 |
| Wax, JR | 1 |
| Philput, C | 1 |
| Steinfeld, JD | 1 |
| Ingardia, CJ | 1 |
| McElhatton, PR | 1 |
| Roberts, JC | 1 |
| Sullivan, FM | 1 |
| Olivieri, NF | 1 |
| Koren, G | 1 |
| Hermann, C | 1 |
| Bentur, Y | 1 |
| Chung, D | 1 |
| Klein, J | 1 |
| St Louis, P | 1 |
| Freedman, MH | 1 |
| McClelland, RA | 1 |
| Templeton, DM | 1 |
| Daly, AL | 1 |
| Velazquez, LA | 1 |
| Bradley, SF | 1 |
| Kauffman, CA | 1 |
2 reviews available for deferoxamine and Drug Overdose
| Article | Year |
|---|---|
Intentional iron overdose in pregnancy--management and outcome.
Topics: Adolescent; Adult; Analysis of Variance; Chelating Agents; Deferoxamine; Drug Overdose; Emergency Se | 2000 |
Mucormycosis: association with deferoxamine therapy.
Topics: Deferoxamine; Drug Overdose; Female; Humans; Iron; Middle Aged; Mucormycosis; Myelodysplastic Syndro | 1989 |
1 trial available for deferoxamine and Drug Overdose
| Article | Year |
|---|---|
Comparison of oral iron chelator L1 and desferrioxamine in iron-loaded patients.
Topics: Adolescent; Adult; Anemia, Aplastic; Animals; Blood Transfusion; Child; Cohort Studies; Combined Mod | 1990 |
13 other studies available for deferoxamine and Drug Overdose
| Article | Year |
|---|---|
The Dark Side of Iron.
Topics: Acidosis; Adolescent; Anemia, Iron-Deficiency; Deferoxamine; Drug Overdose; Female; Ferrous Compound | 2020 |
Near fatal iron intoxication managed conservatively.
Topics: Acute Disease; Deferoxamine; Dehydration; Drug Overdose; Emergency Service, Hospital; Female; Fluid | 2013 |
Acute renal failure following deferoxamine overdose.
Topics: Acute Kidney Injury; Adolescent; Anemia, Sickle Cell; beta-Thalassemia; Deferoxamine; Drug Overdose; | 2003 |
Performance characteristics of the Dimension RxL iron and total iron-binding capacity methods.
Topics: Anemia, Iron-Deficiency; Deferoxamine; Drug Overdose; Hemoglobins; Humans; Iron; Iron Chelating Agen | 2003 |
Acute renal failure following deferoxamine overdose.
Topics: Acute Kidney Injury; Adolescent; Adult; beta-Thalassemia; Deferoxamine; Drug Overdose; Female; Human | 2003 |
Acute liver failure due to iron overdose in an adult.
Topics: Adolescent; Alanine Transaminase; Deferoxamine; Drug Overdose; Female; Humans; Iron; Iron Chelating | 2005 |
Acute respiratory distress syndrome due to overdose desferrioxamine: report of a child.
Topics: Deferoxamine; Drug Overdose; Female; Humans; Infant; Respiratory Distress Syndrome; Siderophores | 2005 |
Role of oxygen-derived metabolites in the rat gastric mucosal injury induced by nitric oxide donors.
Topics: Animals; Blood Pressure; Catalase; Deferoxamine; Disease Models, Animal; Drug Overdose; Drug Synergi | 1995 |
Survival after a severe iron poisoning treated with intermittent infusions of deferoxamine.
Topics: Deferoxamine; Drug Administration Schedule; Drug Overdose; Gastric Lavage; Heart; Humans; Infant; In | 1995 |
Iron complexation with oral deferoxamine in a swine model.
Topics: Administration, Oral; Animals; Antidotes; Deferoxamine; Disease Models, Animal; Dose-Response Relati | 1996 |
Leukocytosis, hyperglycemia, vomiting, and positive X-rays are not indicators of severity of iron overdose in adults.
Topics: Adolescent; Adult; Blood Glucose; Deferoxamine; Drug Overdose; Female; Humans; Hyperglycemia; Iron; | 1996 |
Performance characteristics of three serum iron and total iron-binding capacity methods in acute iron overdose.
Topics: Acute Disease; Chelating Agents; Deferoxamine; Drug Overdose; Evaluation Studies as Topic; Humans; I | 1999 |
The consequences of iron overdose and its treatment with desferrioxamine in pregnancy.
Topics: Birth Weight; Deferoxamine; Drug Overdose; Female; Humans; Infant, Newborn; Iron; Male; Pregnancy; P | 1991 |