deferoxamine has been researched along with Down Syndrome in 2 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Down Syndrome: A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Komatsu, T | 1 |
| Lee, MC | 1 |
| Miyagi, A | 1 |
| Shoji, H | 1 |
| Yoshino, F | 1 |
| Maehata, Y | 1 |
| Maetani, T | 1 |
| Kawamura, Y | 1 |
| Ikeda, M | 1 |
| Kubota, E | 1 |
| McLachlan, DR | 1 |
| Kruck, TP | 1 |
| VanBerkum, MF | 1 |
1 review available for deferoxamine and Down Syndrome
| Article | Year |
|---|---|
Aluminum and neurodegenerative disease: therapeutic implications.
Topics: Aluminum; Alzheimer Disease; Amyotrophic Lateral Sclerosis; Animals; Brain; Calcium; Deferoxamine; D | 1985 |
1 other study available for deferoxamine and Down Syndrome
| Article | Year |
|---|---|
Reactive oxygen species generation in gingival fibroblasts of Down syndrome patients detected by electron spin resonance spectroscopy.
Topics: Adult; Catalase; Cell Culture Techniques; Deferoxamine; Down Syndrome; Electron Spin Resonance Spect | 2006 |