deferoxamine has been researched along with Distorted Hearing in 7 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The severe toxic effects on vision, hearing and growth are all more likely at higher doses of DF and there appears to be partial protection against them by iron overload." | 2.38 | The toxic effects of desferrioxamine. ( Huehns, ER; Porter, JB, 1989) |
| "Management of these patients requires proper dosing of desferrioxamine and transfusion therapy, along with regular monitoring of body iron burden and hemoglobin." | 1.30 | Desferrioxamine ototoxicity in an adult transfusion-dependent population. ( Alberti, PW; Chiodo, AA; Francombe, WH; Sher, GD; Tyler, B, 1997) |
| " Several efforts have been made to prevent these toxic side effects." | 1.30 | [Experimental studies of the protective effect of deferoxamine mesilate on cisplatin induced toxicity]. ( Kanno, H; Watanabe, H, 1998) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (28.57) | 18.7374 |
| 1990's | 5 (71.43) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, Y | 1 |
| Wang, J | 1 |
| Huang, W | 1 |
| MartÃn, C | 1 |
| Lens, XM | 1 |
| Prieto, A | 1 |
| Alonso, R | 1 |
| Correa, B | 1 |
| Arcocha, V | 1 |
| Soto, A | 1 |
| Chiodo, AA | 1 |
| Alberti, PW | 1 |
| Sher, GD | 1 |
| Francombe, WH | 1 |
| Tyler, B | 1 |
| Conlon, BJ | 1 |
| Perry, BP | 1 |
| Smith, DW | 1 |
| Watanabe, H | 1 |
| Kanno, H | 1 |
| Porter, JB | 1 |
| Huehns, ER | 1 |
| Freedman, MH | 1 |
| Bentur, Y | 1 |
| Koren, G | 1 |
2 reviews available for deferoxamine and Distorted Hearing
| Article | Year |
|---|---|
The toxic effects of desferrioxamine.
Topics: Animals; Blood-Brain Barrier; Deferoxamine; Disease Susceptibility; Eye Diseases; Growth Disorders; | 1989 |
Biological and toxic properties of deferoxamine.
Topics: Cataract; Cell Division; Deferoxamine; DNA; Drug Hypersensitivity; Hearing Disorders; Humans; Pulmon | 1989 |
5 other studies available for deferoxamine and Distorted Hearing
| Article | Year |
|---|---|
[Deferoxamine protects against gentamicin ototoxicity].
Topics: Animals; Anti-Bacterial Agents; Auditory Threshold; Cochlea; Deferoxamine; Drug Antagonism; Free Rad | 1999 |
[Verification of desferrioxamine ototoxicity by high-frequency audiometry in patients undergoing dialysis].
Topics: Adult; Aluminum; Audiometry; Bone Diseases; Deferoxamine; Dose-Response Relationship, Drug; Female; | 1994 |
Desferrioxamine ototoxicity in an adult transfusion-dependent population.
Topics: Adult; Aged; Anemia, Sickle Cell; Audiometry; beta-Thalassemia; Deferoxamine; Drug Monitoring; Fanco | 1997 |
Attenuation of neomycin ototoxicity by iron chelation.
Topics: Animals; Anti-Bacterial Agents; Auditory Threshold; Deferoxamine; Evoked Potentials, Auditory; Free | 1998 |
[Experimental studies of the protective effect of deferoxamine mesilate on cisplatin induced toxicity].
Topics: Animals; Antineoplastic Agents; Auditory Threshold; Chelating Agents; Cisplatin; Cochlea; Deferoxami | 1998 |