deferoxamine has been researched along with Di Guglielmo Disease in 19 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We hypothesize that the relatively higher bioavailability of nontransferrin iron in LIT cells, over that in HID cells, determines the differing responses observed under low-iron conditions." | 1.30 | The inability of cells to grow in low iron correlates with increasing activity of their iron regulatory protein (IRP). ( Kovár, J; Kriegerbecková, K; Kühn, LC; Musílková, J; Richardson, V; Seiser, C, 1997) |
| "G1 arrest of murine erythroleukemia cells induced by aphidicolin or deferoxamine is not associated with accumulation of under-phosphorylated retinoblastoma protein, suppression of cyclin A protein, or commitment of cells to terminal differentiation." | 1.29 | Hexamethylenebisacetamide-induced erythroleukemia cell differentiation involves modulation of events required for cell cycle progression through G1. ( Kiyokawa, H; Marks, PA; Richon, VM; Rifkind, RA; Venta-Perez, G, 1993) |
| "Treatment of K562 cells, a human erythroleukemia cell line, with desferrioxamine raised the levels of the receptor for transferrin (Tf) two- to threefold over that of the control cells." | 1.27 | Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells. ( Bridges, K; Klausner, R; Mattia, E; Rao, KK; Shapiro, D, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 10 (52.63) | 18.7374 |
| 1990's | 8 (42.11) | 18.2507 |
| 2000's | 1 (5.26) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Tahara, T | 1 |
| Sun, J | 1 |
| Nakanishi, K | 1 |
| Yamamoto, M | 1 |
| Mori, H | 1 |
| Saito, T | 1 |
| Fujita, H | 1 |
| Igarashi, K | 1 |
| Taketani, S | 2 |
| Cudkowicz, A | 1 |
| Klausner, RD | 2 |
| Bridges, KR | 3 |
| Gambari, R | 4 |
| Coccia, EM | 2 |
| Stellacci, E | 1 |
| Orsatti, R | 1 |
| Testa, U | 2 |
| Battistini, A | 2 |
| Kiyokawa, H | 1 |
| Richon, VM | 1 |
| Venta-Perez, G | 1 |
| Rifkind, RA | 1 |
| Marks, PA | 1 |
| Weiss, G | 1 |
| Graziadel, I | 1 |
| Urbanek, M | 1 |
| Grünewald, K | 1 |
| Vogel, W | 1 |
| Kovár, J | 1 |
| Kühn, LC | 1 |
| Richardson, V | 1 |
| Seiser, C | 1 |
| Kriegerbecková, K | 1 |
| Musílková, J | 1 |
| Haile, DJ | 1 |
| Rouault, TA | 1 |
| Tang, CK | 1 |
| Chin, J | 1 |
| Harford, JB | 1 |
| Furukawa, T | 1 |
| Naitoh, Y | 1 |
| Kohno, H | 1 |
| Tokunaga, R | 1 |
| Profita, V | 1 |
| Fiorucci, G | 1 |
| Romeo, G | 1 |
| Affabris, E | 1 |
| Hentze, MW | 1 |
| Fargion, S | 1 |
| Fracanzani, AL | 1 |
| Cislaghi, V | 1 |
| Levi, S | 1 |
| Cappellini, MD | 1 |
| Fiorelli, G | 1 |
| Shterman, N | 1 |
| Kupfer, B | 1 |
| Moroz, C | 1 |
| Nastruzzi, C | 3 |
| Walde, P | 1 |
| Menegatti, E | 1 |
| Mattia, E | 2 |
| den Blaauwen, J | 1 |
| Ashwell, G | 1 |
| van Renswoude, J | 1 |
| Rao, KK | 1 |
| Shapiro, D | 1 |
| Bridges, K | 1 |
| Klausner, R | 1 |
| Bottomley, SS | 1 |
| Wolfe, LC | 1 |
| Feriotto, G | 2 |
| Barbieri, R | 2 |
| Hoffman, KE | 1 |
| Traniello, F | 1 |
19 other studies available for deferoxamine and Di Guglielmo Disease
| Article | Year |
|---|---|
Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells.
Topics: Animals; Basic-Leucine Zipper Transcription Factors; Binding Sites; Blotting, Northern; Cell Line; C | 2004 |
Regulation of the transferrin receptor in K562 erythroleukemia cells.
Topics: Cells, Cultured; Chelating Agents; Deferoxamine; Humans; Iron; Leukemia, Erythroblastic, Acute; Rece | 1984 |
Desferrioxamine-mediated inhibition of heme and hemoglobin synthesis in murine erythroleukemia cells: expression of globin genes and commitment to erythroid differentiation.
Topics: Acetamides; Animals; Cell Differentiation; Cell Division; Cells, Cultured; Deferoxamine; Erythropoie | 1983 |
Regulation of ferritin H-chain expression in differentiating Friend leukemia cells.
Topics: Acetamides; Animals; Cell Differentiation; Deferoxamine; Dimethyl Sulfoxide; Erythroid Precursor Cel | 1995 |
Hexamethylenebisacetamide-induced erythroleukemia cell differentiation involves modulation of events required for cell cycle progression through G1.
Topics: Acetamides; Animals; Aphidicolin; Cell Differentiation; Cyclins; Deferoxamine; G1 Phase; Leukemia, E | 1993 |
Divergent effects of alpha 1-antitrypsin on the regulation of iron metabolism in human erythroleukaemic (K562) and myelomonocytic (THP-1) cells.
Topics: alpha 1-Antitrypsin; Cell Line; Deferoxamine; Ferritins; Humans; Iron; Iron-Regulatory Proteins; Iro | 1996 |
The inability of cells to grow in low iron correlates with increasing activity of their iron regulatory protein (IRP).
Topics: Biological Transport; Burkitt Lymphoma; Cell Division; Culture Media; Deferoxamine; HeLa Cells; Huma | 1997 |
Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.
Topics: Aconitate Hydratase; Animals; Cell Line; Deferoxamine; Dithiothreitol; Edetic Acid; Heme; Humans; Ir | 1992 |
Iron deprivation decreases ribonucleotide reductase activity and DNA synthesis.
Topics: Antibodies, Monoclonal; Cell Division; Deferoxamine; DNA; Ferric Compounds; Humans; Iron Deficiencie | 1992 |
Modulation of ferritin H-chain expression in Friend erythroleukemia cells: transcriptional and translational regulation by hemin.
Topics: Animals; Base Sequence; Deferoxamine; Ferric Compounds; Ferritins; Gene Expression Regulation, Neopl | 1992 |
Characteristics of the membrane receptor for human H-ferritin.
Topics: Cell Differentiation; Cell Division; Cell Line; Deferoxamine; Erythrocytes; Erythroid Precursor Cell | 1991 |
Expression of messenger RNA species coding for a Mr 43,000 peptide associated with ferritin in human leukemia-K562 cells and its down regulation during differentiation.
Topics: Cell Line; Deferoxamine; Ferritins; Heme; Humans; Leukemia, Erythroblastic, Acute; Molecular Weight; | 1989 |
Differential effects of liposome-entrapped desferrioxamine on proliferation and erythroid differentiation of murine erythroleukemic Friend cells.
Topics: Animals; Cell Differentiation; Cell Division; Cell Line; Deferoxamine; Freeze Fracturing; Friend mur | 1989 |
Multiple post-transcriptional regulatory mechanisms in ferritin gene expression.
Topics: Cell Nucleus; Deferoxamine; Ferritins; Gene Expression Regulation; Hemin; Humans; Iron; Kinetics; Le | 1989 |
Effects of alterations in cellular iron on biosynthesis of the transferrin receptor in K562 cells.
Topics: Cell Line; Cells, Cultured; Deferoxamine; Humans; Iron; Kinetics; Leukemia, Erythroblastic, Acute; M | 1985 |
Iron metabolism in K562 erythroleukemic cells.
Topics: Cell Line; Deferoxamine; Heme; Heptanoates; Humans; Iron; Leukemia, Erythroblastic, Acute; Receptors | 1985 |
Induction to erythroid differentiation of K562 cells by 1-beta-D-arabinofuranosylcytosine is inhibited by iron chelators: reversion by treatment with hemin.
Topics: Cell Differentiation; Cell Line; Cytarabine; Deferoxamine; Erythropoiesis; Growth Inhibitors; Heme; | 1988 |
The effects of ascorbic acid on the intracellular metabolism of iron and ferritin.
Topics: Animals; Ascorbic Acid; Cell Line; Deferoxamine; Dose-Response Relationship, Drug; Ferritins; Iron; | 1986 |
Hemin uptake by erythroleukemic cells treated with iron chelators: effects on the induced expression of differentiated functions.
Topics: Cell Line; Cytarabine; Deferoxamine; Heme; Hemin; Hemoglobins; Humans; Leukemia, Erythroblastic, Acu | 1987 |