deferoxamine has been researched along with Complications of Diabetes Mellitus in 11 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Deferiprone (L1) was found to have greater efficacy at depleting myocardial iron than desferrioxamine (DFX)." | 5.32 | Combined therapy with deferiprone and desferrioxamine successfully regresses severe heart failure in patients with beta-thalassemia major. ( Chang, JS; Peng, CT; Tsai, CH; Wu, KH, 2004) |
| "Deferiprone (L1) was found to have greater efficacy at depleting myocardial iron than desferrioxamine (DFX)." | 1.32 | Combined therapy with deferiprone and desferrioxamine successfully regresses severe heart failure in patients with beta-thalassemia major. ( Chang, JS; Peng, CT; Tsai, CH; Wu, KH, 2004) |
| "To describe the burden of thalassemia major and its treatment, in terms of prevalence of iron-overload-related complications, direct and indirect costs, and the patient's physical and social well-being." | 1.31 | Impact of thalassemia major on patients and their families. ( Arana, A; Caro, JJ; Eleftheriou, A; Green, TC; Huybrechts, K; Wait, S; Ward, A, 2002) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (36.36) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 3 (27.27) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kong, L | 1 |
| Wu, Z | 1 |
| Zhao, H | 1 |
| Cui, H | 1 |
| Shen, J | 1 |
| Chang, J | 1 |
| Li, H | 1 |
| He, Y | 1 |
| Scott, C | 1 |
| Bonner, J | 1 |
| Min, D | 1 |
| Boughton, P | 1 |
| Stokes, R | 1 |
| Cha, KM | 1 |
| Walters, SN | 1 |
| Maslowski, K | 1 |
| Sierro, F | 1 |
| Grey, ST | 1 |
| Twigg, S | 1 |
| McLennan, S | 1 |
| Gunton, JE | 1 |
| Duscher, D | 1 |
| Neofytou, E | 1 |
| Wong, VW | 1 |
| Maan, ZN | 1 |
| Rennert, RC | 1 |
| Inayathullah, M | 1 |
| Januszyk, M | 2 |
| Rodrigues, M | 1 |
| Malkovskiy, AV | 1 |
| Whitmore, AJ | 1 |
| Walmsley, GG | 1 |
| Galvez, MG | 2 |
| Whittam, AJ | 1 |
| Brownlee, M | 2 |
| Rajadas, J | 1 |
| Gurtner, GC | 2 |
| Thangarajah, H | 1 |
| Yao, D | 1 |
| Chang, EI | 1 |
| Shi, Y | 1 |
| Jazayeri, L | 1 |
| Vial, IN | 1 |
| Galiano, RD | 1 |
| Du, XL | 1 |
| Grogan, R | 1 |
| Wu, KH | 1 |
| Chang, JS | 1 |
| Tsai, CH | 1 |
| Peng, CT | 1 |
| Gancz, AY | 1 |
| Wellehan, JF | 1 |
| Boutette, J | 1 |
| Malka, S | 1 |
| Lee, SE | 1 |
| Smith, DA | 1 |
| Taylor, M | 1 |
| Caro, JJ | 1 |
| Ward, A | 1 |
| Green, TC | 1 |
| Huybrechts, K | 1 |
| Arana, A | 1 |
| Wait, S | 1 |
| Eleftheriou, A | 1 |
| Strohmeyer, G | 1 |
| Krüger, N | 1 |
| Stubbe, P | 1 |
| Tillmann, W | 1 |
| Schröter, W | 1 |
| Rahko, PS | 1 |
| Salerni, R | 1 |
| Uretsky, BF | 1 |
| Barth, J | 1 |
| Petter, O | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Deferoxamine on Wound Healing Rate in Patients With Diabetes Foot Ulcers[NCT03137966] | Phase 2 | 174 participants (Anticipated) | Interventional | 2022-12-30 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for deferoxamine and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
[Iron storage disorders].
Topics: Arrhythmias, Cardiac; Bloodletting; Deferoxamine; Diabetes Complications; Ferritins; Follicle Stimul | 1978 |
10 other studies available for deferoxamine and Complications of Diabetes Mellitus
| Article | Year |
|---|---|
Bioactive Injectable Hydrogels Containing Desferrioxamine and Bioglass for Diabetic Wound Healing.
Topics: Ceramics; Deferoxamine; Diabetes Complications; Endothelial Cells; Gene Expression Regulation; Human | 2018 |
Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing.
Topics: Aged; Animals; Aryl Hydrocarbon Receptor Nuclear Translocator; Case-Control Studies; Cells, Cultured | 2014 |
Transdermal deferoxamine prevents pressure-induced diabetic ulcers.
Topics: Administration, Cutaneous; Animals; Apoptosis; Deferoxamine; Dermis; Diabetes Complications; Diabete | 2015 |
The molecular basis for impaired hypoxia-induced VEGF expression in diabetic tissues.
Topics: Animals; Cells, Cultured; Deferoxamine; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus | 2009 |
Combined therapy with deferiprone and desferrioxamine successfully regresses severe heart failure in patients with beta-thalassemia major.
Topics: Adult; beta-Thalassemia; Cardiovascular Agents; Deferiprone; Deferoxamine; Diabetes Complications; D | 2004 |
Diabetes mellitus concurrent with hepatic haemosiderosis in two macaws (Ara severa, Ara militaris).
Topics: Animals; Deferoxamine; Diabetes Complications; Female; Hemosiderosis; Insulin; Liver Diseases; Male; | 2007 |
Impact of thalassemia major on patients and their families.
Topics: Adolescent; Adult; beta-Thalassemia; Child; Cost of Illness; Deferoxamine; Diabetes Complications; E | 2002 |
[Continuous subcutaneous deferoxamine infusions in thalassemia major. Improvement in glucose tolerance].
Topics: Adolescent; Adult; alpha-Amylases; Blood Glucose; Child; Child, Preschool; Deferoxamine; Diabetes Co | 1986 |
Successful reversal by chelation therapy of congestive cardiomyopathy due to iron overload.
Topics: Adult; Anemia, Macrocytic; Anemia, Megaloblastic; Deferoxamine; Diabetes Complications; Echocardiogr | 1986 |
[Catamnestic studies in porphyria cutanea tarda with special reference to therapy].
Topics: Adenine Nucleotides; Adenosine Triphosphate; Adult; Aged; Bloodletting; Deferoxamine; Diabetes Compl | 1971 |