deferoxamine and Coma
deferoxamine has been researched along with Coma in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we retrospectively measured baseline saturations in stored serum samples from 81 Zambian children with strictly defined cerebral malaria." | 9.08 | Transferrin saturation and recovery from coma in cerebral malaria. ( Askin, JE; Biemba, G; Brittenham, GM; Gordeuk, VR; McLaren, CE; Poltera, AA; Thuma, PE; Zulu, S, 1995) |
| "To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we retrospectively measured baseline saturations in stored serum samples from 81 Zambian children with strictly defined cerebral malaria." | 5.08 | Transferrin saturation and recovery from coma in cerebral malaria. ( Askin, JE; Biemba, G; Brittenham, GM; Gordeuk, VR; McLaren, CE; Poltera, AA; Thuma, PE; Zulu, S, 1995) |
| "To determine whether combining iron chelation with quinine therapy speeds the recovery of consciousness, we conducted a randomized, double-blind, placebo-controlled trial of the iron chelator deferoxamine in 83 Zambian children with cerebral malaria." | 5.07 | Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. ( Backenstose, A; Biemba, G; Brittenham, G; Gordeuk, V; Holmes, L; McKinley, E; McLaren, C; Msiska, R; Parry, D; Thuma, P, 1992) |
Research
Studies (6)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 5 (83.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Erasmus, RT | 1 |
| Kusnir, J | 1 |
| Stevenson, WC | 1 |
| Lobo, P | 1 |
| Herman, MM | 1 |
| Wills, MR | 1 |
| Savory, J | 1 |
| Gordeuk, VR | 1 |
| Thuma, PE | 1 |
| McLaren, CE | 1 |
| Biemba, G | 2 |
| Zulu, S | 1 |
| Poltera, AA | 1 |
| Askin, JE | 1 |
| Brittenham, GM | 1 |
| Taylor, TE | 1 |
| Molyneux, ME | 1 |
| Fruchter, O | 1 |
| Gordeuk, V | 1 |
| Thuma, P | 1 |
| Brittenham, G | 1 |
| McLaren, C | 1 |
| Parry, D | 1 |
| Backenstose, A | 1 |
| Msiska, R | 1 |
| Holmes, L | 1 |
| McKinley, E | 1 |
| Westlin, WF | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Application of Iron Chelator (Desferal) to Reduce the Severity of COVID-19 Manifestations[NCT04333550] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2020-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Trials
2 trials available for deferoxamine and Coma
| Article | Year |
|---|---|
Transferrin saturation and recovery from coma in cerebral malaria.
Topics: Chelation Therapy; Child, Preschool; Cohort Studies; Coma; Deferoxamine; Double-Blind Method; Drug T | 1995 |
Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria.
Topics: Child, Preschool; Coma; Consciousness; Deferoxamine; Double-Blind Method; Drug Therapy, Combination; | 1992 |
Other Studies
4 other studies available for deferoxamine and Coma
| Article | Year |
|---|---|
Hyperaluminemia associated with liver transplantation and acute renal failure.
Topics: Acute Kidney Injury; Albumins; Aluminum; Ammonia; Antidotes; Chelating Agents; Coma; Deferoxamine; D | 1995 |
Folate deficiency to protect against malaria.
Topics: Chemotherapy, Adjuvant; Child; Coma; Deferoxamine; Humans; Malaria, Cerebral | 1993 |
Artemether in severe malaria.
Topics: Antimalarials; Artemether; Artemisinins; Chelation Therapy; Child; Coma; Deferoxamine; Humans; Malar | 1996 |
Deferoxamine in the treatment of acute iron poisoning. Clinical experiences with 172 children.
Topics: Adolescent; Blood Chemical Analysis; Child; Child, Preschool; Coma; Deferoxamine; Female; Humans; In | 1966 |