Page last updated: 2024-10-25

deferoxamine and Coma

deferoxamine has been researched along with Coma in 6 studies

Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.

Coma: A profound state of unconsciousness associated with depressed cerebral activity from which the individual cannot be aroused. Coma generally occurs when there is dysfunction or injury involving both cerebral hemispheres or the brain stem RETICULAR FORMATION.

Research Excerpts

ExcerptRelevanceReference
"To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we retrospectively measured baseline saturations in stored serum samples from 81 Zambian children with strictly defined cerebral malaria."9.08Transferrin saturation and recovery from coma in cerebral malaria. ( Askin, JE; Biemba, G; Brittenham, GM; Gordeuk, VR; McLaren, CE; Poltera, AA; Thuma, PE; Zulu, S, 1995)
"To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we retrospectively measured baseline saturations in stored serum samples from 81 Zambian children with strictly defined cerebral malaria."5.08Transferrin saturation and recovery from coma in cerebral malaria. ( Askin, JE; Biemba, G; Brittenham, GM; Gordeuk, VR; McLaren, CE; Poltera, AA; Thuma, PE; Zulu, S, 1995)
"To determine whether combining iron chelation with quinine therapy speeds the recovery of consciousness, we conducted a randomized, double-blind, placebo-controlled trial of the iron chelator deferoxamine in 83 Zambian children with cerebral malaria."5.07Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. ( Backenstose, A; Biemba, G; Brittenham, G; Gordeuk, V; Holmes, L; McKinley, E; McLaren, C; Msiska, R; Parry, D; Thuma, P, 1992)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19901 (16.67)18.7374
1990's5 (83.33)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Erasmus, RT1
Kusnir, J1
Stevenson, WC1
Lobo, P1
Herman, MM1
Wills, MR1
Savory, J1
Gordeuk, VR1
Thuma, PE1
McLaren, CE1
Biemba, G2
Zulu, S1
Poltera, AA1
Askin, JE1
Brittenham, GM1
Taylor, TE1
Molyneux, ME1
Fruchter, O1
Gordeuk, V1
Thuma, P1
Brittenham, G1
McLaren, C1
Parry, D1
Backenstose, A1
Msiska, R1
Holmes, L1
McKinley, E1
Westlin, WF1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Application of Iron Chelator (Desferal) to Reduce the Severity of COVID-19 Manifestations[NCT04333550]Phase 1/Phase 250 participants (Anticipated)Interventional2020-04-30Recruiting
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trials

2 trials available for deferoxamine and Coma

ArticleYear
Transferrin saturation and recovery from coma in cerebral malaria.
    Blood, 1995, Jun-01, Volume: 85, Issue:11

    Topics: Chelation Therapy; Child, Preschool; Cohort Studies; Coma; Deferoxamine; Double-Blind Method; Drug T

1995
Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria.
    The New England journal of medicine, 1992, Nov-19, Volume: 327, Issue:21

    Topics: Child, Preschool; Coma; Consciousness; Deferoxamine; Double-Blind Method; Drug Therapy, Combination;

1992

Other Studies

4 other studies available for deferoxamine and Coma

ArticleYear
Hyperaluminemia associated with liver transplantation and acute renal failure.
    Clinical transplantation, 1995, Volume: 9, Issue:4

    Topics: Acute Kidney Injury; Albumins; Aluminum; Ammonia; Antidotes; Chelating Agents; Coma; Deferoxamine; D

1995
Folate deficiency to protect against malaria.
    The New England journal of medicine, 1993, Apr-15, Volume: 328, Issue:15

    Topics: Chemotherapy, Adjuvant; Child; Coma; Deferoxamine; Humans; Malaria, Cerebral

1993
Artemether in severe malaria.
    The New England journal of medicine, 1996, Dec-19, Volume: 335, Issue:25

    Topics: Antimalarials; Artemether; Artemisinins; Chelation Therapy; Child; Coma; Deferoxamine; Humans; Malar

1996
Deferoxamine in the treatment of acute iron poisoning. Clinical experiences with 172 children.
    Clinical pediatrics, 1966, Volume: 5, Issue:9

    Topics: Adolescent; Blood Chemical Analysis; Child; Child, Preschool; Coma; Deferoxamine; Female; Humans; In

1966