deferoxamine has been researched along with Cerebral Malaria in 14 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we retrospectively measured baseline saturations in stored serum samples from 81 Zambian children with strictly defined cerebral malaria." | 9.08 | Transferrin saturation and recovery from coma in cerebral malaria. ( Askin, JE; Biemba, G; Brittenham, GM; Gordeuk, VR; McLaren, CE; Poltera, AA; Thuma, PE; Zulu, S, 1995) |
| "To determine if iron chelation therapy alters immune responses in children with cerebral malaria, we retrospectively measured mean serum levels of neopterin, interleukin-4 (IL-4), and IL-6 in children who received desferrioxamine B or placebo for three days in addition to quinine-based therapy." | 9.08 | Serum neopterin, interleukin-4, and interleukin-6 concentrations in cerebral malaria patients and the effect of iron chelation therapy. ( Gordeuk, VR; Herold, M; Thuma, PE; Weiss, G, 1996) |
| "To determine if the elevated transferrin saturations found in some patients with severe malaria are associated with an adverse outcome in cerebral malaria, we retrospectively measured baseline saturations in stored serum samples from 81 Zambian children with strictly defined cerebral malaria." | 5.08 | Transferrin saturation and recovery from coma in cerebral malaria. ( Askin, JE; Biemba, G; Brittenham, GM; Gordeuk, VR; McLaren, CE; Poltera, AA; Thuma, PE; Zulu, S, 1995) |
| "To determine if iron chelation therapy alters immune responses in children with cerebral malaria, we retrospectively measured mean serum levels of neopterin, interleukin-4 (IL-4), and IL-6 in children who received desferrioxamine B or placebo for three days in addition to quinine-based therapy." | 5.08 | Serum neopterin, interleukin-4, and interleukin-6 concentrations in cerebral malaria patients and the effect of iron chelation therapy. ( Gordeuk, VR; Herold, M; Thuma, PE; Weiss, G, 1996) |
| "To determine whether iron chelation modulates nitric oxide (NO) formation and cell-mediated immune effector function in children with cerebral malaria, serum concentrations were measured of the stable end products of NO, nitrite and nitrate (NO2-/NO3-), interleukin (IL)-4, -6, and -10, and neopterin in 39 Zambian children enrolled in a placebo-controlled trial of desferrioxamine B and quinine therapy." | 5.08 | Modulatory potential of iron chelation therapy on nitric oxide formation in cerebral malaria. ( Gordeuk, VR; Herold, M; Mabeza, G; Thuma, PE; Weiss, G; Werner, ER, 1997) |
| "To determine whether combining iron chelation with quinine therapy speeds the recovery of consciousness, we conducted a randomized, double-blind, placebo-controlled trial of the iron chelator deferoxamine in 83 Zambian children with cerebral malaria." | 5.07 | Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria. ( Backenstose, A; Biemba, G; Brittenham, G; Gordeuk, V; Holmes, L; McKinley, E; McLaren, C; Msiska, R; Parry, D; Thuma, P, 1992) |
| "The study population consisted of 26 Zambian children < 6 years of age who presented with cerebral malaria to a rural hospital in 1994 and who were treated with quinine for seven days." | 3.70 | Prolonged macrophage activation and persistent anaemia in children with complicated malaria. ( Biemba, G; Gordeuk, VR; Mabeza, GF; Thuma, PE; Weiss, G, 1998) |
| "The clinical picture of cerebral malaria may persist or even become worse in spite of the clearance of parasites from blood." | 2.43 | Adjuvant therapy in cerebral malaria. ( Mishra, SK; Mohanty, S; Patel, DK; Pati, SS, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (78.57) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gordeuk, VR | 6 |
| Loyevsky, M | 1 |
| Enwere, G | 1 |
| Mohanty, S | 1 |
| Patel, DK | 1 |
| Pati, SS | 1 |
| Mishra, SK | 1 |
| Thuma, PE | 4 |
| McLaren, CE | 1 |
| Biemba, G | 3 |
| Zulu, S | 1 |
| Poltera, AA | 1 |
| Askin, JE | 1 |
| Brittenham, GM | 2 |
| Taylor, TE | 2 |
| Molyneux, ME | 1 |
| Weiss, G | 3 |
| Herold, M | 2 |
| Looareesuwan, S | 1 |
| Wilairatana, P | 1 |
| Vannaphan, S | 1 |
| Meshnick, SR | 1 |
| Fruchter, O | 1 |
| Mabeza, G | 1 |
| Werner, ER | 1 |
| Mabeza, GF | 1 |
| White, NJ | 1 |
| Gordeuk, V | 1 |
| Thuma, P | 1 |
| Brittenham, G | 1 |
| McLaren, C | 1 |
| Parry, D | 1 |
| Backenstose, A | 1 |
| Msiska, R | 1 |
| Holmes, L | 1 |
| McKinley, E | 1 |
| Wyler, DJ | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Application of Iron Chelator (Desferal) to Reduce the Severity of COVID-19 Manifestations[NCT04333550] | Phase 1/Phase 2 | 50 participants (Anticipated) | Interventional | 2020-04-30 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for deferoxamine and Cerebral Malaria
| Article | Year |
|---|---|
Antimalarial effect of iron chelators.
Topics: Animals; Antimalarials; Child; Deferiprone; Deferoxamine; Drug Therapy, Combination; Humans; In Vitr | 2002 |
A review of the quality of randomized clinical trials of adjunctive therapy for the treatment of cerebral malaria.
Topics: Anticonvulsants; Deferoxamine; Dexamethasone; Double-Blind Method; Enzyme Inhibitors; Humans; Malari | 2005 |
Adjuvant therapy in cerebral malaria.
Topics: Adrenal Cortex Hormones; Antimalarials; Blood-Brain Barrier; Chemotherapy, Adjuvant; Deferoxamine; H | 2006 |
6 trials available for deferoxamine and Cerebral Malaria
| Article | Year |
|---|---|
Transferrin saturation and recovery from coma in cerebral malaria.
Topics: Chelation Therapy; Child, Preschool; Cohort Studies; Coma; Deferoxamine; Double-Blind Method; Drug T | 1995 |
Serum neopterin, interleukin-4, and interleukin-6 concentrations in cerebral malaria patients and the effect of iron chelation therapy.
Topics: Biopterins; Child, Preschool; Deferoxamine; Double-Blind Method; Female; Humans; Infant; Interleukin | 1996 |
Co-administration of desferrioxamine B with artesunate in malaria: an assessment of safety and tolerance.
Topics: Adolescent; Adult; Antimalarials; Artemisinins; Artesunate; Deferoxamine; Drug Therapy, Combination; | 1996 |
Modulatory potential of iron chelation therapy on nitric oxide formation in cerebral malaria.
Topics: Biopterins; Chelation Therapy; Child; Child, Preschool; Deferoxamine; Double-Blind Method; Humans; I | 1997 |
Effect of iron chelation therapy on recovery from deep coma in children with cerebral malaria.
Topics: Child, Preschool; Coma; Consciousness; Deferoxamine; Double-Blind Method; Drug Therapy, Combination; | 1992 |
Bark, weeds, and iron chelators--drugs for malaria.
Topics: Antimalarials; Child; Deferoxamine; Humans; Malaria, Cerebral; Malaria, Falciparum | 1992 |
5 other studies available for deferoxamine and Cerebral Malaria
| Article | Year |
|---|---|
Folate deficiency to protect against malaria.
Topics: Chemotherapy, Adjuvant; Child; Coma; Deferoxamine; Humans; Malaria, Cerebral | 1993 |
Artemether in severe malaria.
Topics: Antimalarials; Artemether; Artemisinins; Chelation Therapy; Child; Coma; Deferoxamine; Humans; Malar | 1996 |
Prolonged macrophage activation and persistent anaemia in children with complicated malaria.
Topics: Analysis of Variance; Anemia; Antimalarials; Child, Preschool; Deferoxamine; Drug Therapy, Combinati | 1998 |
Not much progress in treatment of cerebral malaria.
Topics: Adult; Animals; Antimalarials; Child; Deferoxamine; Humans; Iron Chelating Agents; Malaria, Cerebral | 1998 |
Desferrioxamine and cerebral malaria.
Topics: Child; Deferoxamine; Humans; Malaria, Cerebral | 1992 |