deferoxamine has been researched along with Cell Transformation, Neoplastic in 5 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Cell Transformation, Neoplastic: Cell changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm, and other attributes conferring the ability to invade, metastasize, and kill.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We show here that bladder cancer cell proliferation in vitro is dependent on Tf-Fe." | 1.29 | Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation. ( Domenico, J; Gelfand, EW; Schleicher, RB; Seligman, PA; Siriwardana, G, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Noor, A | 1 |
| Van Zuylekom, JK | 1 |
| Rudd, SE | 1 |
| Waldeck, K | 1 |
| Roselt, PD | 1 |
| Haskali, MB | 1 |
| Wheatcroft, MP | 1 |
| Yan, E | 1 |
| Hicks, RJ | 1 |
| Cullinane, C | 1 |
| Donnelly, PS | 1 |
| Burvenich, IJ | 1 |
| Parakh, S | 1 |
| Gan, HK | 1 |
| Lee, FT | 1 |
| Guo, N | 1 |
| Rigopoulos, A | 1 |
| Lee, ST | 1 |
| Gong, S | 1 |
| O'Keefe, GJ | 1 |
| Tochon-Danguy, H | 1 |
| Kotsuma, M | 1 |
| Hasegawa, J | 1 |
| Senaldi, G | 1 |
| Scott, AM | 1 |
| Lu, H | 1 |
| Li, Y | 1 |
| Shu, M | 1 |
| Tang, J | 1 |
| Huang, Y | 1 |
| Zhou, Y | 1 |
| Liang, Y | 1 |
| Yan, G | 1 |
| Schimmel, M | 1 |
| Bauer, G | 1 |
| Seligman, PA | 1 |
| Schleicher, RB | 1 |
| Siriwardana, G | 1 |
| Domenico, J | 1 |
| Gelfand, EW | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Metformin and Neo-adjuvant Temozolomide and Hypofractionated Accelerated Limited-margin Radiotherapy Followed by Adjuvant Temozolomide in Patients With Glioblastoma Multiforme (M-HARTT STUDY)[NCT02780024] | Phase 2 | 50 participants (Anticipated) | Interventional | 2015-03-31 | Active, not recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 other studies available for deferoxamine and Cell Transformation, Neoplastic
| Article | Year |
|---|---|
Bivalent Inhibitors of Prostate-Specific Membrane Antigen Conjugated to Desferrioxamine B Squaramide Labeled with Zirconium-89 or Gallium-68 for Diagnostic Imaging of Prostate Cancer.
Topics: Animals; Antigens, Surface; Cell Line, Tumor; Cell Transformation, Neoplastic; Deferoxamine; Enzyme | 2020 |
Molecular Imaging and Quantitation of EphA2 Expression in Xenograft Models with 89Zr-DS-8895a.
Topics: Animals; Antibodies, Monoclonal, Humanized; Cell Line, Tumor; Cell Transformation, Neoplastic; Defer | 2016 |
Hypoxia-inducible factor-1alpha blocks differentiation of malignant gliomas.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cell Transformation, Neoplastic; Cobalt; Colforsin; | 2009 |
Proapoptotic and redox state-related signaling of reactive oxygen species generated by transformed fibroblasts.
Topics: Acetophenones; Animals; Apoptosis; Buthionine Sulfoximine; Catalase; Cell Line, Transformed; Cell Tr | 2002 |
Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation.
Topics: Cell Transformation, Neoplastic; Deferoxamine; Gallium; Humans; Indium; Iron; Protein Binding; Trans | 1993 |