deferoxamine has been researched along with Cataract in 15 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Cataract: Partial or complete opacity on or in the lens or capsule of one or both eyes, impairing vision or causing blindness. The many kinds of cataract are classified by their morphology (size, shape, location) or etiology (cause and time of occurrence). (Dorland, 27th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test whether iron accumulation in the lens following cigarette smoke exposure is the principal mechanism in smoke-related cataractogenesis and to assess the possible protective effect of deferoxamine mesylate treatment against lenticular degeneration with in vivo exposure to cigarette smoke." | 7.70 | Cataractous changes in rat lens following cigarette smoke exposure is prevented by parenteral deferoxamine therapy. ( Avunduk, AM; Avunduk, MC; Kurnaz, L; Yardimci, S, 1999) |
| "A single subcutaneous dose of 30 nmol of sodium selenite per gram of body weight in 13-day-old rats resulted in posterior subcapsular cataract (PSC) after 24 hr and bilateral nuclear cataracts at 72-96 hr." | 7.68 | Deferoxamine effect on selenite-induced cataract formation in rats. ( Bunce, GE; Hess, JL; Wang, Z, 1992) |
| "To test whether iron accumulation in the lens following cigarette smoke exposure is the principal mechanism in smoke-related cataractogenesis and to assess the possible protective effect of deferoxamine mesylate treatment against lenticular degeneration with in vivo exposure to cigarette smoke." | 3.70 | Cataractous changes in rat lens following cigarette smoke exposure is prevented by parenteral deferoxamine therapy. ( Avunduk, AM; Avunduk, MC; Kurnaz, L; Yardimci, S, 1999) |
| "A single subcutaneous dose of 30 nmol of sodium selenite per gram of body weight in 13-day-old rats resulted in posterior subcapsular cataract (PSC) after 24 hr and bilateral nuclear cataracts at 72-96 hr." | 3.68 | Deferoxamine effect on selenite-induced cataract formation in rats. ( Bunce, GE; Hess, JL; Wang, Z, 1992) |
| "Lens opacities were presented in 14 patients--22%." | 1.30 | [The mechanism of cataract formation in persons with beta-thalassemia]. ( Padakis, A; Popescu, C; Siganos, D; Zanakis, E, 1998) |
| "Amiodarone hydrochloride is a benzofurane derivative used to combat cardiac arrhythmia since 1960." | 1.27 | [Cataracts]. ( Hachet, E, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 6 (40.00) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Schaal, S | 2 |
| Beiran, I | 2 |
| Bormusov, E | 1 |
| Chevion, M | 2 |
| Dovrat, A | 2 |
| Rozner, H | 1 |
| Rubinstein, I | 1 |
| Miller, B | 1 |
| Davies, SC | 1 |
| Marcus, RE | 1 |
| Hungerford, JL | 1 |
| Miller, MH | 1 |
| Arden, GB | 1 |
| Huehns, ER | 1 |
| Rinaldi, M | 1 |
| Della Corte, M | 1 |
| Ruocco, V | 1 |
| D'Onofrio, C | 1 |
| Zanotta, G | 1 |
| Romano, A | 1 |
| Popescu, C | 1 |
| Siganos, D | 1 |
| Zanakis, E | 1 |
| Padakis, A | 1 |
| Avunduk, AM | 1 |
| Yardimci, S | 1 |
| Avunduk, MC | 1 |
| Kurnaz, L | 1 |
| Wang, Z | 1 |
| Hess, JL | 1 |
| Bunce, GE | 1 |
| Bhuyan, KC | 1 |
| Bhuyan, DK | 1 |
| Chiu, W | 1 |
| Malik, S | 1 |
| Fridovich, I | 1 |
| Sorcinelli, R | 1 |
| Sitzia, A | 1 |
| Figus, A | 1 |
| Lai, ME | 1 |
| Caballero, LG | 1 |
| Schindléry, C | 1 |
| Freedman, MH | 1 |
| Bentur, Y | 1 |
| Koren, G | 1 |
| Hachet, E | 1 |
| Brückner, R | 1 |
| Hess, R | 1 |
| Keberle, H | 1 |
| Pericin, C | 1 |
| Tripod, J | 1 |
| Diwany, M | 1 |
| Gabr, M | 1 |
| el Hefni, A | 1 |
| Mokhtar, N | 1 |
2 reviews available for deferoxamine and Cataract
| Article | Year |
|---|---|
[Auditory, visual and neurologic toxicity of deferoxamine].
Topics: Adolescent; Cataract; Deferoxamine; Hearing Loss, Sensorineural; Humans; Male; Middle Aged | 1989 |
Biological and toxic properties of deferoxamine.
Topics: Cataract; Cell Division; Deferoxamine; DNA; Drug Hypersensitivity; Hearing Disorders; Humans; Pulmon | 1989 |
13 other studies available for deferoxamine and Cataract
| Article | Year |
|---|---|
Zinc-desferrioxamine reduces damage to lenses exposed to hyperbaric oxygen and has an ameliorative effect on catalase and Na, K-ATPase activities.
Topics: Animals; Antioxidants; Catalase; Cataract; Cattle; Deferoxamine; Histocytochemistry; Hyperbaric Oxyg | 2007 |
Desferrioxamine and zinc-desferrioxamine reduce lens oxidative damage.
Topics: Animals; Antioxidants; Cataract; Cattle; Deferoxamine; Histocytochemistry; Hyperbaric Oxygenation; I | 2007 |
Ocular toxicity of high-dose intravenous desferrioxamine.
Topics: Adolescent; Adult; Cataract; Child; Child, Preschool; Dark Adaptation; Deferoxamine; Female; Follow- | 1983 |
Ocular involvement correlated with age in patients affected by major and intermedia beta-thalassemia treated or not with desferrioxamine.
Topics: Adolescent; Adult; Age Factors; Angioid Streaks; beta-Thalassemia; Cataract; Child; Child, Preschool | 1993 |
[The mechanism of cataract formation in persons with beta-thalassemia].
Topics: Adolescent; Adult; beta-Thalassemia; Blood Transfusion; Cataract; Child; Corneal Opacity; Deferoxami | 1998 |
Cataractous changes in rat lens following cigarette smoke exposure is prevented by parenteral deferoxamine therapy.
Topics: Animals; Calcium; Cataract; Deferoxamine; Infusions, Parenteral; Iron; Iron Chelating Agents; Lens, | 1999 |
Deferoxamine effect on selenite-induced cataract formation in rats.
Topics: Animals; Body Weight; Calcium; Cataract; Deferoxamine; Disease Models, Animal; Glutathione; Injectio | 1992 |
Desferal-Mn(III) in the therapy of diquat-induced cataract in rabbit.
Topics: Animals; Ascorbic Acid; Cataract; Deferoxamine; Diquat; Free Radicals; Glutathione; Hydrogen Peroxid | 1991 |
Ocular findings in beta-thalassemia.
Topics: Adolescent; Adult; Blood Transfusion; Cataract; Child; Deferoxamine; Eye Diseases; Female; Humans; M | 1990 |
Acute visual and auditory neurotoxicity in patients with end-stage renal disease receiving desferrioxamine.
Topics: Cataract; Deferoxamine; Humans | 1989 |
[Cataracts].
Topics: Adrenal Cortex Hormones; Allopurinol; Amiodarone; Animals; Antimalarials; Antineoplastic Agents; Ant | 1985 |
[Pathologic lens changes in experimental animals following continuous administration of high doses of Desferal].
Topics: Animals; Cataract; Cats; Deferoxamine; Dogs; Edetic Acid; Female; Galactose; Lens, Crystalline; Male | 1967 |
Desferrioxamine in thalassaemia.
Topics: Adolescent; Bone Marrow; Cataract; Child; Child, Preschool; Deferoxamine; Female; Hemoglobinometry; | 1968 |