deferoxamine has been researched along with Brain Ischemia in 24 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Brain Ischemia: Localized reduction of blood flow to brain tissue due to arterial obstruction or systemic hypoperfusion. This frequently occurs in conjunction with brain hypoxia (HYPOXIA, BRAIN). Prolonged ischemia is associated with BRAIN INFARCTION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown." | 9.27 | Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage. ( Alborch, E; Castelló-Ruiz, M; Castillo, J; Dávalos, A; DeGregorio-Rocasolano, N; García-Yébenes, I; Gasull, T; Guirao, V; Lizasoain, I; Martí-Sistac, O; Millán, M; Ponce, J; Ramos-Cabrer, P; Salom, JB, 2018) |
| "In the present study, the effects of deferoxamine on tissue lactate and malondialdehyde (MDA) levels after cerebral ischemia in rabbits was studied." | 7.72 | Effects of deferoxamine on tissue lactate and malondialdehyde levels in cerebral ischemia. ( Ak, A; Bariskaner, H; Dogan, N; Gurbilek, M; Ustun, ME; Yosunkaya, A, 2003) |
| "Deferoxamine (DFO) is a high-affinity iron chelator approved by the Food and Drug Administration for treating iron overload." | 5.35 | Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. ( Coppes, VG; Frey, WH; Hanson, LR; Hoekman, JD; Marti, DL; Martinez, PM; Matthews, RB; Panter, SS; Rao, RJ; Roeytenberg, A; Sweet, DC, 2009) |
| "Incomplete cerebral ischemia was produced by intracranial pressure elevation for 30 minutes with plasma glucose at 540 +/- 15 mg/dL." | 5.29 | Deferoxamine reduces early metabolic failure associated with severe cerebral ischemic acidosis in dogs. ( Blizzard, KK; Hurn, PD; Koehler, RC; Traystman, RJ, 1995) |
| "Despite transferrin being the main circulating carrier of iron in body fluids, and iron overload conditions being known to worsen stroke outcome through reactive oxygen species (ROS)-induced damage, the contribution of blood transferrin saturation (TSAT) to stroke brain damage is unknown." | 5.27 | Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage. ( Alborch, E; Castelló-Ruiz, M; Castillo, J; Dávalos, A; DeGregorio-Rocasolano, N; García-Yébenes, I; Gasull, T; Guirao, V; Lizasoain, I; Martí-Sistac, O; Millán, M; Ponce, J; Ramos-Cabrer, P; Salom, JB, 2018) |
| "In the present study, the effects of deferoxamine on tissue lactate and malondialdehyde (MDA) levels after cerebral ischemia in rabbits was studied." | 3.72 | Effects of deferoxamine on tissue lactate and malondialdehyde levels in cerebral ischemia. ( Ak, A; Bariskaner, H; Dogan, N; Gurbilek, M; Ustun, ME; Yosunkaya, A, 2003) |
| "Deferoxamine (DFO) is a high-affinity iron chelator approved by the Food and Drug Administration for treating iron overload." | 1.35 | Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. ( Coppes, VG; Frey, WH; Hanson, LR; Hoekman, JD; Marti, DL; Martinez, PM; Matthews, RB; Panter, SS; Rao, RJ; Roeytenberg, A; Sweet, DC, 2009) |
| "Rat model of cerebral ischemia was established by middle cerebral artery occlusion with or without DFO administration." | 1.35 | Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin. ( Ding, SJ; Guo, W; Li, YX; Xiao, L; Zhan, Q, 2008) |
| "Incomplete cerebral ischemia was produced by intracranial pressure elevation for 30 minutes with plasma glucose at 540 +/- 15 mg/dL." | 1.29 | Deferoxamine reduces early metabolic failure associated with severe cerebral ischemic acidosis in dogs. ( Blizzard, KK; Hurn, PD; Koehler, RC; Traystman, RJ, 1995) |
| "The area of cerebral infarction was measured at three levels using video imaging methods." | 1.29 | Failure of iron chelators to protect against cerebral infarction in hypoxia-ischemia. ( Davis, J; Fridovich, I; MacMillan, V, 1993) |
| "Animals subjected to cardiac arrest and resuscitation and standard intensive care (SIC) had LMWC iron levels of 37." | 1.27 | Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest. ( Aust, SD; Bialek, H; Evans, AT; Huang, RR; Indrieri, RJ; Jacobs, WA; Komara, J; Nayini, NR; White, BC, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (8.33) | 18.7374 |
| 1990's | 11 (45.83) | 18.2507 |
| 2000's | 6 (25.00) | 29.6817 |
| 2010's | 4 (16.67) | 24.3611 |
| 2020's | 1 (4.17) | 2.80 |
| Authors | Studies |
|---|---|
| Liu, H | 1 |
| Schwarting, J | 1 |
| Terpolilli, NA | 1 |
| Nehrkorn, K | 1 |
| Plesnila, N | 1 |
| DeGregorio-Rocasolano, N | 1 |
| Martí-Sistac, O | 1 |
| Ponce, J | 1 |
| Castelló-Ruiz, M | 1 |
| Millán, M | 1 |
| Guirao, V | 1 |
| García-Yébenes, I | 1 |
| Salom, JB | 1 |
| Ramos-Cabrer, P | 1 |
| Alborch, E | 1 |
| Lizasoain, I | 1 |
| Castillo, J | 1 |
| Dávalos, A | 1 |
| Gasull, T | 1 |
| Jones, SM | 1 |
| Novak, AE | 1 |
| Elliott, JP | 1 |
| Egashira, Y | 1 |
| Xi, G | 1 |
| Chaudhary, N | 1 |
| Hua, Y | 1 |
| Pandey, AS | 1 |
| Wilks, MQ | 1 |
| Normandin, MD | 1 |
| Yuan, H | 1 |
| Cho, H | 1 |
| Guo, Y | 1 |
| Herisson, F | 1 |
| Ayata, C | 1 |
| Wooten, DW | 1 |
| El Fakhri, G | 1 |
| Josephson, L | 1 |
| Hanson, LR | 1 |
| Roeytenberg, A | 1 |
| Martinez, PM | 1 |
| Coppes, VG | 1 |
| Sweet, DC | 1 |
| Rao, RJ | 1 |
| Marti, DL | 1 |
| Hoekman, JD | 1 |
| Matthews, RB | 1 |
| Frey, WH | 1 |
| Panter, SS | 1 |
| Liachenko, S | 1 |
| Tang, P | 1 |
| Xu, Y | 1 |
| Bariskaner, H | 1 |
| Ustun, ME | 1 |
| Ak, A | 1 |
| Yosunkaya, A | 1 |
| Dogan, N | 1 |
| Gurbilek, M | 1 |
| Chi, OZ | 1 |
| Hunter, C | 1 |
| Liu, X | 1 |
| Weiss, HR | 1 |
| Li, YX | 1 |
| Ding, SJ | 1 |
| Xiao, L | 1 |
| Guo, W | 1 |
| Zhan, Q | 1 |
| Chu, K | 1 |
| Jung, KH | 1 |
| Kim, SJ | 1 |
| Lee, ST | 1 |
| Kim, J | 1 |
| Park, HK | 1 |
| Song, EC | 1 |
| Kim, SU | 1 |
| Kim, M | 1 |
| Lee, SK | 1 |
| Roh, JK | 1 |
| Hurn, PD | 1 |
| Koehler, RC | 1 |
| Blizzard, KK | 1 |
| Traystman, RJ | 2 |
| Sorrenti, V | 1 |
| Di Giacomo, C | 1 |
| Renis, M | 1 |
| Russo, A | 1 |
| La Delfa, C | 1 |
| Perez-Polo, JR | 1 |
| Vanella, A | 1 |
| Palmer, C | 1 |
| Roberts, RL | 1 |
| Bero, C | 1 |
| MacMillan, V | 1 |
| Fridovich, I | 1 |
| Davis, J | 1 |
| Li, Y | 1 |
| Bickel, KD | 1 |
| Im, MJ | 1 |
| Hu, L | 1 |
| Dellon, AL | 1 |
| Vander Kolk, CA | 1 |
| Manson, PN | 1 |
| Shadid, M | 2 |
| Buonocore, G | 1 |
| Groenendaal, F | 1 |
| Moison, R | 2 |
| Ferrali, M | 1 |
| Berger, HM | 2 |
| van Bel, F | 2 |
| Steendijk, P | 1 |
| Hiltermann, L | 1 |
| Rosenthal, RE | 1 |
| Chanderbhan, R | 1 |
| Marshall, G | 1 |
| Fiskum, G | 1 |
| Soloniuk, DS | 1 |
| Perkins, E | 1 |
| Wilson, JR | 1 |
| Kirsch, JR | 1 |
| Helfaer, MA | 1 |
| Lange, DG | 1 |
| Patt, A | 1 |
| Horesh, IR | 1 |
| Berger, EM | 1 |
| Harken, AH | 1 |
| Repine, JE | 1 |
| Nayini, NR | 1 |
| White, BC | 1 |
| Aust, SD | 1 |
| Huang, RR | 1 |
| Indrieri, RJ | 1 |
| Evans, AT | 1 |
| Bialek, H | 1 |
| Jacobs, WA | 1 |
| Komara, J | 1 |
| Babbs, CF | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind, Randomized, Placebo Controlled, Dose-finding Phase 2 Clinical Trial of Intravenous Deferoxamine in Patients With Acute Ischemic Stroke Treated With Tissue Plasminogen Activator[NCT00777140] | Phase 2 | 62 participants (Actual) | Interventional | 2008-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for deferoxamine and Brain Ischemia
| Article | Year |
|---|---|
Evidence for free radical mechanisms of brain injury resulting from ischemia/reperfusion-induced events.
Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Deferoxamine; Free Radical Scavengers; Free Radicals | 1992 |
Role of iron ions in the genesis of reperfusion injury following successful cardiopulmonary resuscitation: preliminary data and a biochemical hypothesis.
Topics: Animals; Brain Ischemia; Deferoxamine; Free Radicals; Heart Arrest; Humans; Hydroxylation; Ions; Iro | 1985 |
1 trial available for deferoxamine and Brain Ischemia
| Article | Year |
|---|---|
Iron-loaded transferrin (Tf) is detrimental whereas iron-free Tf confers protection against brain ischemia by modifying blood Tf saturation and subsequent neuronal damage.
Topics: Animals; Apoproteins; Brain Ischemia; Deferoxamine; Female; Humans; Iron; Iron Overload; Lipid Perox | 2018 |
21 other studies available for deferoxamine and Brain Ischemia
| Article | Year |
|---|---|
Scavenging Free Iron Reduces Arteriolar Microvasospasms After Experimental Subarachnoid Hemorrhage.
Topics: Animals; Arterioles; Brain Ischemia; Capillaries; Deferoxamine; Iron; Male; Mice, Inbred C57BL; Side | 2021 |
The role of HIF in cobalt-induced ischemic tolerance.
Topics: Amino Acids, Dicarboxylic; Animals; Astrocytes; Brain Ischemia; Cell Survival; Cells, Cultured; Coba | 2013 |
Acute Brain Injury after Subarachnoid Hemorrhage.
Topics: Acute Disease; Acute-Phase Proteins; Animals; Brain Injuries; Brain Ischemia; Deferoxamine; Hemoglob | 2015 |
Imaging PEG-like nanoprobes in tumor, transient ischemia, and inflammatory disease models.
Topics: Animals; Brain; Brain Ischemia; Carbocyanines; Cell Line, Tumor; Deferoxamine; Female; Inflammation; | 2015 |
Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke.
Topics: Administration, Intranasal; Animals; Behavior, Animal; Brain; Brain Ischemia; Deferoxamine; Dose-Res | 2009 |
Deferoxamine improves early postresuscitation reperfusion after prolonged cardiac arrest in rats.
Topics: Animals; Blood Pressure; Brain Ischemia; Cerebrovascular Circulation; Deferoxamine; Heart Arrest; He | 2003 |
Effects of deferoxamine on tissue lactate and malondialdehyde levels in cerebral ischemia.
Topics: Acute Disease; Animals; Brain; Brain Ischemia; Deferoxamine; Electroencephalography; Iron Chelating | 2003 |
Effects of deferoxamine on blood-brain barrier disruption and VEGF in focal cerebral ischemia.
Topics: Aminoisobutyric Acids; Animals; Blood Pressure; Blood-Brain Barrier; Brain Ischemia; Capillary Perme | 2008 |
Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin.
Topics: Animals; Brain Ischemia; Cells, Cultured; Cerebral Infarction; Deferoxamine; Disease Models, Animal; | 2008 |
Transplantation of human neural stem cells protect against ischemia in a preventive mode via hypoxia-inducible factor-1alpha stabilization in the host brain.
Topics: Animals; Brain; Brain Infarction; Brain Ischemia; Chemokine CXCL12; Cyclooxygenase 2; Deferoxamine; | 2008 |
Deferoxamine reduces early metabolic failure associated with severe cerebral ischemic acidosis in dogs.
Topics: Acidosis; Adenosine Triphosphate; Animals; Brain Ischemia; Deferoxamine; Disease Models, Animal; Dog | 1995 |
Lipid peroxidation and survival in rats following cerebral post-ischaemic reperfusion: effect of drugs with different molecular mechanisms.
Topics: Allopurinol; Animals; Antioxidants; Brain Ischemia; Deferoxamine; Diltiazem; Lipid Peroxidation; Mal | 1994 |
Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats.
Topics: Animals; Animals, Newborn; Brain Ischemia; Deferoxamine; Female; Hypoxia, Brain; Male; Rats | 1994 |
Failure of iron chelators to protect against cerebral infarction in hypoxia-ischemia.
Topics: Animals; Brain; Brain Ischemia; Carbon Monoxide; Cerebral Infarction; Deferoxamine; Hypoxia, Brain; | 1993 |
Effects of deferoxamine on ischemia/reperfusion injury after peripheral nerve compression.
Topics: Animals; Blotting, Western; Brain; Brain Ischemia; Deferoxamine; Iron Chelating Agents; Male; Nerve | 1996 |
Effect of deferoxamine and allopurinol on non-protein-bound iron concentrations in plasma and cortical brain tissue of newborn lambs following hypoxia-ischemia.
Topics: Allopurinol; Animals; Animals, Newborn; Brain Ischemia; Cerebral Cortex; Deferoxamine; Hypoxia, Brai | 1998 |
The effect of antioxidative combination therapy on post hypoxic-ischemic perfusion, metabolism, and electrical activity of the newborn brain.
Topics: Allopurinol; Animals; Animals, Newborn; Antioxidants; Asphyxia Neonatorum; Brain; Brain Ischemia; Cy | 1998 |
Prevention of post-ischemic brain lipid conjugated diene production and neurological injury by hydroxyethyl starch-conjugated deferoxamine.
Topics: Alkenes; Animals; Brain Ischemia; Deferoxamine; Free Radicals; Heart Arrest; Hydroxyethyl Starch Der | 1992 |
Use of allopurinol and deferoxamine in cellular protection during ischemia.
Topics: Allopurinol; Animals; Brain Ischemia; Cell Death; Cerebral Infarction; Deferoxamine; Rats | 1992 |
Iron depletion or chelation reduces ischemia/reperfusion-induced edema in gerbil brains.
Topics: Animals; Brain; Brain Chemistry; Brain Edema; Brain Ischemia; Deferoxamine; Female; Gerbillinae; Hem | 1990 |
Post resuscitation iron delocalization and malondialdehyde production in the brain following prolonged cardiac arrest.
Topics: Animals; Brain Ischemia; Deferoxamine; Dogs; Free Radicals; Heart Arrest; Iron Chelating Agents; Lid | 1985 |