deferoxamine has been researched along with Brain Injuries in 21 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Brain Injuries: Acute and chronic (see also BRAIN INJURIES, CHRONIC) injuries to the brain, including the cerebral hemispheres, CEREBELLUM, and BRAIN STEM. Clinical manifestations depend on the nature of injury. Diffuse trauma to the brain is frequently associated with DIFFUSE AXONAL INJURY or COMA, POST-TRAUMATIC. Localized injuries may be associated with NEUROBEHAVIORAL MANIFESTATIONS; HEMIPARESIS, or other focal neurologic deficits.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Deferoxamine may be a therapy for patients with IVH or intraventricular extension after intracerebral hemorrhage." | 3.77 | Role of iron in brain injury after intraventricular hemorrhage. ( Chen, Z; Gao, C; Hua, Y; Keep, RF; Muraszko, K; Xi, G, 2011) |
| "Deferoxamine (DFX) has recently been shown to have a neuroprotective effect in animal models of subarachnoid haemorrhage (SAH)." | 1.40 | Possible involvement of cathepsin B/D and caspase-3 in deferoxamine-related neuroprotection of early brain injury after subarachnoid haemorrhage in rats. ( Chen, G; Jia, Y; Yu, ZQ, 2014) |
| "Deferoxamine treatment attenuated TBI-induced hydrocephalus and heme oxygenase-1 upregulation." | 1.40 | Deferoxamine attenuates acute hydrocephalus after traumatic brain injury in rats. ( Chen, Z; Hua, Y; Keep, RF; Xi, G; Zhao, J, 2014) |
| "Nimodipine was given at a dose of 1 mg/kg 1 hour before and 2 hours after the cold lesion." | 1.29 | Proposed toxic oxidant inhibitors fail to reduce brain edema. ( Bulkley, GB; Hedlund, BE; Judy, KD; Long, DM, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (38.10) | 18.2507 |
| 2000's | 1 (4.76) | 29.6817 |
| 2010's | 10 (47.62) | 24.3611 |
| 2020's | 2 (9.52) | 2.80 |
| Authors | Studies |
|---|---|
| Jones, NM | 1 |
| Nathanson, AD | 1 |
| Chell, S | 1 |
| DeAngelis, E | 1 |
| Whelan, G | 1 |
| Willé, D | 1 |
| Cheng, K | 1 |
| Yu, X | 1 |
| Ma, X | 1 |
| Lyu, J | 1 |
| Jiang, N | 1 |
| Lu, Y | 1 |
| Liao, Y | 1 |
| Wang, K | 1 |
| Yu, W | 1 |
| Zhu, Q | 1 |
| Gong, Y | 1 |
| Guo, T | 1 |
| Deng, J | 1 |
| Ji, J | 1 |
| Wang, B | 1 |
| Hao, S | 1 |
| Kapoor, S | 1 |
| Yu, ZQ | 1 |
| Jia, Y | 1 |
| Chen, G | 1 |
| Zhao, J | 1 |
| Chen, Z | 2 |
| Xi, G | 4 |
| Keep, RF | 3 |
| Hua, Y | 4 |
| Egashira, Y | 1 |
| Chaudhary, N | 1 |
| Pandey, AS | 1 |
| Li, Y | 1 |
| Yang, H | 1 |
| Ni, W | 1 |
| Gu, Y | 1 |
| Ohnishi, M | 1 |
| Katsuki, H | 1 |
| Unemura, K | 1 |
| Izumi, Y | 1 |
| Kume, T | 1 |
| Takada-Takatori, Y | 1 |
| Akaike, A | 1 |
| Gao, C | 1 |
| Muraszko, K | 1 |
| Lee, JY | 1 |
| Ernestus, RI | 1 |
| Zhang, L | 1 |
| Hu, R | 1 |
| Li, M | 1 |
| Li, F | 1 |
| Meng, H | 1 |
| Zhu, G | 1 |
| Lin, J | 1 |
| Feng, H | 1 |
| Judy, KD | 1 |
| Bulkley, GB | 1 |
| Hedlund, BE | 1 |
| Long, DM | 2 |
| Long, DA | 1 |
| Ghosh, K | 1 |
| Moore, AN | 1 |
| Dixon, CE | 1 |
| Dash, PK | 1 |
| Regan, RF | 1 |
| Panter, SS | 1 |
| Heegaard, W | 1 |
| Biros, M | 1 |
| Zink, J | 1 |
| Rauhala, P | 1 |
| Khaldi, A | 1 |
| Mohanakumar, KP | 1 |
| Chiueh, CC | 1 |
| Hoffman, SW | 1 |
| Rzigalinski, BA | 1 |
| Willoughby, KA | 1 |
| Ellis, EF | 1 |
| Kontos, HA | 1 |
| Wei, EP | 1 |
| Kirsch, JR | 1 |
| Helfaer, MA | 1 |
| Lange, DG | 1 |
| Traystman, RJ | 1 |
| Ikeda, Y | 1 |
1 review available for deferoxamine and Brain Injuries
| Article | Year |
|---|---|
Evidence for free radical mechanisms of brain injury resulting from ischemia/reperfusion-induced events.
Topics: Animals; Brain; Brain Injuries; Brain Ischemia; Deferoxamine; Free Radical Scavengers; Free Radicals | 1992 |
20 other studies available for deferoxamine and Brain Injuries
| Article | Year |
|---|---|
The prolyl hydroxylase inhibitor GSK1120360A reduces early brain injury, but protection is not maintained in a neonatal rat model of hypoxic ischaemic encephalopathy.
Topics: Animals; Animals, Newborn; Brain; Brain Injuries; Deferoxamine; Hypoxia; Hypoxia-Ischemia, Brain; Me | 2022 |
Ferroptosis involved in sevoflurane-aggravated young rats brain injury induced by liver transplantation.
Topics: Animals; Brain Injuries; Child; Deferoxamine; Ferroptosis; Humans; Iron; Ischemia; Liver; Liver Tran | 2022 |
Thermo-sensitive keratin hydrogel against iron-induced brain injury after experimental intracerebral hemorrhage.
Topics: Acrylic Resins; Adsorption; Animals; Behavior, Animal; Brain; Brain Injuries; Cerebral Hemorrhage; D | 2019 |
Deferoxamine: emerging, new neuro-protective benefits.
Topics: Animals; Brain Injuries; Deferoxamine; Iron; Male; Neurotoxicity Syndromes; Siderophores | 2013 |
Possible involvement of cathepsin B/D and caspase-3 in deferoxamine-related neuroprotection of early brain injury after subarachnoid haemorrhage in rats.
Topics: Animals; Apoptosis; Blood-Brain Barrier; Brain Injuries; Caspase 3; Cathepsin B; Cathepsin D; Defero | 2014 |
Deferoxamine attenuates acute hydrocephalus after traumatic brain injury in rats.
Topics: Acute Disease; Animals; Brain; Brain Injuries; Deferoxamine; Hydrocephalus; Iron; Lateral Ventricles | 2014 |
Acute Brain Injury after Subarachnoid Hemorrhage.
Topics: Acute Disease; Acute-Phase Proteins; Animals; Brain Injuries; Brain Ischemia; Deferoxamine; Hemoglob | 2015 |
Effects of deferoxamine on blood-brain barrier disruption after subarachnoid hemorrhage.
Topics: Animals; Behavior, Animal; Blood-Brain Barrier; Brain Edema; Brain Injuries; Cognition; Deferoxamine | 2017 |
Heme oxygenase-1 contributes to pathology associated with thrombin-induced striatal and cortical injury in organotypic slice culture.
Topics: Animals; Animals, Newborn; Astrocytes; Brain Injuries; Cerebral Cortex; Corpus Striatum; Deferoxamin | 2010 |
Role of iron in brain injury after intraventricular hemorrhage.
Topics: Animals; Brain Injuries; Cerebral Hemorrhage; Deferoxamine; Hippocampus; Iron; Lateral Ventricles; M | 2011 |
Deferoxamine reduces early brain injury following subarachnoid hemorrhage.
Topics: Analysis of Variance; Animals; Brain; Brain Injuries; Deferoxamine; Disease Models, Animal; DNA Dama | 2011 |
Deferoxamine attenuates iron-induced long-term neurotoxicity in rats with traumatic brain injury.
Topics: Analysis of Variance; Animals; Apoferritins; Atrophy; Brain; Brain Injuries; Deferoxamine; Disease M | 2013 |
Proposed toxic oxidant inhibitors fail to reduce brain edema.
Topics: Allopurinol; Animals; Brain Edema; Brain Injuries; Calcium; Cats; Cerebral Cortex; Cerebral Infarcti | 1994 |
Deferoxamine improves spatial memory performance following experimental brain injury in rats.
Topics: Animals; Brain Injuries; Cell Size; Deferoxamine; Hippocampus; Maze Learning; Memory; Motor Activity | 1996 |
Hemoglobin potentiates excitotoxic injury in cortical cell culture.
Topics: Adult; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Antioxid | 1996 |
Effect of hypothermia, dichloroacetate, and deferoxamine in the treatment for cortical edema and functional recovery after experimental cortical impact in the rat.
Topics: Animals; Brain Edema; Brain Injuries; Deferoxamine; Dichloroacetic Acid; Hypothermia, Induced; Male; | 1997 |
Apparent role of hydroxyl radicals in oxidative brain injury induced by sodium nitroprusside.
Topics: Animals; Ascorbic Acid; Brain Injuries; Deferoxamine; Hydrogen Peroxide; Hydroxyl Radical; In Vitro | 1998 |
Astrocytes generate isoprostanes in response to trauma or oxygen radicals.
Topics: Animals; Astrocytes; Brain; Brain Injuries; Cells, Cultured; Cerebral Arteries; Cerebrovascular Circ | 2000 |
Endothelium-dependent responses after experimental brain injury.
Topics: Acetylcholine; Animals; Brain Injuries; Catalase; Cats; Cerebrovascular Circulation; Deferoxamine; E | 1992 |
Comparative effects of direct and indirect hydroxyl radical scavengers on traumatic brain oedema.
Topics: Animals; Body Water; Brain; Brain Edema; Brain Injuries; Cats; Deferoxamine; Dimethyl Sulfoxide; Fre | 1990 |