deferoxamine has been researched along with Brain Injuries, Traumatic in 4 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Brain Injuries, Traumatic: A form of acquired brain injury which occurs when a sudden trauma causes damage to the brain.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Deferoxamine (DFO), which is an iron chelator, has been shown to inhibit neuron degeneration; however, the role of DFO in TBI is unclear." | 1.91 | Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury. ( Cao, Y; Chen, F; Jia, H; Li, F; Li, R; Liu, X; Niu, H; Shi, M; Sun, D; Wa, L; Yang, G; Zhang, J; Zhang, S, 2023) |
| "Deferoxamine treatment in mice significantly decreased the levels of both amyloid-β(1-42) and ferritin in the brain, and reduced TBI-induced neural cell apoptosis." | 1.62 | Deferoxamine reduces amyloid-beta peptides genesis and alleviates neural apoptosis after traumatic brain injury. ( Deji, QZ; Deng, HJ; Gao, CC; Gao, SQ; Han, YL; Li, T; Liu, XL; Zhaba, WD; Zhou, ML, 2021) |
| "Deferoxamine (DFX) has been reported to have neuroprotective effect." | 1.56 | HIF-1α and VEGF Are Involved in Deferoxamine-Ameliorated Traumatic Brain Injury. ( Chen, S; Gong, Q; Jing, Y; Wang, K; Xu, C; Zhao, J, 2020) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 3 (75.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, H | 1 |
| Liu, X | 2 |
| Cao, Y | 1 |
| Niu, H | 1 |
| Li, R | 1 |
| Li, F | 1 |
| Sun, D | 1 |
| Shi, M | 1 |
| Wa, L | 1 |
| Yang, G | 1 |
| Chen, F | 1 |
| Zhang, S | 1 |
| Zhang, J | 1 |
| Wang, K | 1 |
| Jing, Y | 1 |
| Xu, C | 1 |
| Zhao, J | 2 |
| Gong, Q | 1 |
| Chen, S | 1 |
| Zhaba, WD | 1 |
| Deji, QZ | 1 |
| Gao, SQ | 1 |
| Han, YL | 1 |
| Gao, CC | 1 |
| Deng, HJ | 1 |
| Liu, XL | 1 |
| Li, T | 1 |
| Zhou, ML | 1 |
| Xi, G | 1 |
| Wu, G | 1 |
| Keep, RF | 1 |
| Hua, Y | 1 |
4 other studies available for deferoxamine and Brain Injuries, Traumatic
| Article | Year |
|---|---|
Deferoxamine ameliorates neurological dysfunction by inhibiting ferroptosis and neuroinflammation after traumatic brain injury.
Topics: Animals; Brain Injuries, Traumatic; Deferoxamine; Ferroptosis; Iron; Mice; Neuroinflammatory Disease | 2023 |
HIF-1α and VEGF Are Involved in Deferoxamine-Ameliorated Traumatic Brain Injury.
Topics: Animals; Apoptosis; Behavior, Animal; Brain; Brain Injuries, Traumatic; Deferoxamine; Disease Models | 2020 |
Deferoxamine reduces amyloid-beta peptides genesis and alleviates neural apoptosis after traumatic brain injury.
Topics: Adult; Amyloid beta-Peptides; Animals; Apoptosis; Brain; Brain Injuries, Traumatic; Deferoxamine; Fe | 2021 |
Deferoxamine Attenuated the Upregulation of Lipocalin-2 Induced by Traumatic Brain Injury in Rats.
Topics: Animals; Astrocytes; Blotting, Western; Brain; Brain Injuries, Traumatic; Cerebral Cortex; Deferoxam | 2016 |