deferoxamine has been researched along with Brain Hemorrhage in 6 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Iron chelation and iron overload was achieved by deferoxamine mesylate or iron dextran injection." | 8.02 | Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice. ( Chen, WX; Feng, H; Ge, HF; Guo, C; Li, CC; Tang, XQ; Wang, B; Wang, J; Xia, M; Yin, Y, 2021) |
| " This study examined the role of deferoxamine (DFX) in brain injury and HT in a rat model of transient focal ischemia with hyperglycemia." | 7.75 | Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia. ( Hua, Y; Keep, RF; Xi, G; Xing, Y, 2009) |
| " Iron chelation and iron overload was achieved by deferoxamine mesylate or iron dextran injection." | 4.02 | Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice. ( Chen, WX; Feng, H; Ge, HF; Guo, C; Li, CC; Tang, XQ; Wang, B; Wang, J; Xia, M; Yin, Y, 2021) |
| "These results indicate that membrane attack complex and erythrophagocytosis contribute to hematoma clearance after ICH, which can be altered by deferoxamine treatment." | 3.83 | Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage. ( Cao, S; Chen, G; Hua, Y; Keep, RF; Xi, G; Zheng, M, 2016) |
| " This study examined the role of deferoxamine (DFX) in brain injury and HT in a rat model of transient focal ischemia with hyperglycemia." | 3.75 | Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia. ( Hua, Y; Keep, RF; Xi, G; Xing, Y, 2009) |
| "Deferoxamine was used as an iron chelator." | 1.33 | Long-term effects of experimental intracerebral hemorrhage: the role of iron. ( Hoff, JT; Hua, Y; Keep, RF; Nakamura, T; Schallert, T; Wu, J; Xi, G, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Pandey, AS | 1 |
| Daou, BJ | 1 |
| Chaudhary, N | 1 |
| Xi, G | 4 |
| Wang, J | 1 |
| Tang, XQ | 1 |
| Xia, M | 1 |
| Li, CC | 1 |
| Guo, C | 1 |
| Ge, HF | 1 |
| Yin, Y | 1 |
| Wang, B | 1 |
| Chen, WX | 1 |
| Feng, H | 1 |
| Klebe, D | 1 |
| Krafft, PR | 1 |
| Hoffmann, C | 1 |
| Lekic, T | 1 |
| Flores, JJ | 1 |
| Rolland, W | 1 |
| Zhang, JH | 1 |
| Cao, S | 1 |
| Zheng, M | 1 |
| Hua, Y | 3 |
| Chen, G | 1 |
| Keep, RF | 3 |
| Xing, Y | 1 |
| Nakamura, T | 1 |
| Wu, J | 1 |
| Schallert, T | 1 |
| Hoff, JT | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Safety of Surgical Treatment In Severe Primary Pontine Hemorrhage Evacuation (STIPE): a Multicentric, Randomized, Controlled, Open-label Trial[NCT04647162] | 64 participants (Anticipated) | Interventional | 2022-01-01 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for deferoxamine and Brain Hemorrhage
| Article | Year |
|---|---|
A combination of Deferoxamine mesylate and minimally invasive surgery with hematoma lysis for evacuation of intracerebral hemorrhage.
Topics: Clinical Trials as Topic; Deferoxamine; Female; Humans; Intracranial Hemorrhages; Male; Minimally In | 2020 |
5 other studies available for deferoxamine and Brain Hemorrhage
| Article | Year |
|---|---|
Iron chelation suppresses secondary bleeding after intracerebral hemorrhage in angiotensin II-infused mice.
Topics: Angiotensin II; Animals; Cerebral Hemorrhage; Deferoxamine; Drug Combinations; Hemoglobins; Hyperten | 2021 |
Acute and delayed deferoxamine treatment attenuates long-term sequelae after germinal matrix hemorrhage in neonatal rats.
Topics: Animals; Animals, Newborn; Brain; Deferoxamine; Disease Models, Animal; Intracranial Hemorrhages; Ma | 2014 |
Hematoma Changes During Clot Resolution After Experimental Intracerebral Hemorrhage.
Topics: Animals; Complement Membrane Attack Complex; Deferoxamine; Disease Models, Animal; Hematoma; Hemolys | 2016 |
Effects of deferoxamine on brain injury after transient focal cerebral ischemia in rats with hyperglycemia.
Topics: Animals; Blood-Brain Barrier; Body Water; Brain; Brain Chemistry; Brain Edema; Deferoxamine; Hemoglo | 2009 |
Long-term effects of experimental intracerebral hemorrhage: the role of iron.
Topics: Animals; Atrophy; Behavior, Animal; Brain; Deferoxamine; Ferritins; Intracranial Hemorrhages; Iron; | 2006 |