deferoxamine has been researched along with Bone Loss, Osteoclastic in 13 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Dose-response studies supported the divergent effects of deferoxamine and dimethyloxalylglycine in RAW 264." | 1.46 | Effect of prolyl hydroxylase inhibitor-loaded collagen barrier membranes on osteoclastogenesis and osteoblastogenesis. ( Agis, H; Al-Habbal, D; Edelmayer, M; Janjić, K; Pensch, M, 2017) |
| "With regard to bone resorption and remodeling markers, the urinary excretion of pyridinium crosslinks was higher in patients with thalassemia for HP fraction (p < 0." | 1.33 | Chelation therapy and bone metabolism markers in thalassemia major. ( De Sanctis, V; Fornasari, PM; Fortini, M; Gamberini, MR; Marconi, S; Pratelli, L; Verri, E; Zolezzi, C, 2006) |
| "Inhibition of bone resorption in the isolated osteoclast system increased in parallel to the concentration of DMnC in cultures." | 1.28 | Nitroblue tetrazolium reduction and bone resorption by osteoclasts in vitro inhibited by a manganese-based superoxide dismutase mimic. ( Key, LL; Ries, WL; Rodriguiz, RM, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (15.38) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 1 (7.69) | 29.6817 |
| 2010's | 6 (46.15) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
| Authors | Studies |
|---|---|
| Sheng, H | 1 |
| Lao, Y | 1 |
| Zhang, S | 1 |
| Ding, W | 1 |
| Lu, D | 1 |
| Xu, B | 1 |
| Edelmayer, M | 1 |
| Al-Habbal, D | 1 |
| Pensch, M | 1 |
| Janjić, K | 1 |
| Agis, H | 1 |
| Zhang, J | 2 |
| Zheng, L | 1 |
| Wang, Z | 1 |
| Pei, H | 1 |
| Hu, W | 2 |
| Nie, J | 1 |
| Shang, P | 1 |
| Li, B | 1 |
| Hei, TK | 1 |
| Zhou, G | 1 |
| Guo, C | 2 |
| Yang, K | 2 |
| Yan, Y | 2 |
| Yan, D | 1 |
| Cheng, Y | 1 |
| Yan, X | 1 |
| Qian, N | 2 |
| Zhou, Q | 1 |
| Chen, B | 1 |
| Jiang, M | 1 |
| Zhou, H | 1 |
| Li, C | 2 |
| Wang, F | 2 |
| Qi, J | 2 |
| Xu, X | 2 |
| Deng, L | 2 |
| Ding, C | 1 |
| Yao, G | 1 |
| Zhao, H | 1 |
| Wu, S | 1 |
| Xu, Z | 1 |
| Sun, W | 1 |
| Li, Y | 2 |
| Ling, S | 1 |
| Zhao, C | 1 |
| Zhong, G | 1 |
| Zhao, D | 1 |
| Song, J | 1 |
| Song, H | 1 |
| Li, J | 1 |
| You, L | 1 |
| Nie, G | 1 |
| Chang, Y | 1 |
| Kang, H | 1 |
| Jia, P | 1 |
| Chen, H | 1 |
| Guo, L | 1 |
| Pratelli, L | 1 |
| Verri, E | 1 |
| Fortini, M | 1 |
| Marconi, S | 1 |
| Zolezzi, C | 1 |
| Fornasari, PM | 1 |
| Gamberini, MR | 1 |
| De Sanctis, V | 1 |
| Hall, TJ | 1 |
| Schaeublin, M | 1 |
| Jeker, H | 1 |
| Fuller, K | 1 |
| Chambers, TJ | 1 |
| Key, LL | 2 |
| Ries, WL | 2 |
| Glasscock, H | 1 |
| Rodriguiz, R | 1 |
| Jaffe, H | 1 |
| Rodriguiz, RM | 1 |
| Faugere, MC | 1 |
| Arnala, IO | 1 |
| Ritz, E | 1 |
| Malluche, HH | 1 |
| Hess, T | 1 |
| Gautschi, K | 1 |
| Jungbluth, H | 1 |
| Binswanger, U | 1 |
13 other studies available for deferoxamine and Bone Loss, Osteoclastic
| Article | Year |
|---|---|
Combined Pharmacotherapy with Alendronate and Desferoxamine Regulate the Bone Resorption and Bone Regeneration for Preventing Glucocorticoids-Induced Osteonecrosis of the Femoral Head.
Topics: Alendronate; Animals; beta Catenin; Bone Regeneration; Bone Resorption; Deferoxamine; Drug Therapy, | 2020 |
Effect of prolyl hydroxylase inhibitor-loaded collagen barrier membranes on osteoclastogenesis and osteoblastogenesis.
Topics: Alkaline Phosphatase; Amino Acids, Dicarboxylic; Animals; Biological Transport; Bone Resorption; Cel | 2017 |
Lowering iron level protects against bone loss in focally irradiated and contralateral femurs through distinct mechanisms.
Topics: Animals; Bone Resorption; Cancellous Bone; Cell Differentiation; Deferoxamine; Femur; Hepcidins; Iro | 2019 |
SF-deferoxamine, a bone-seeking angiogenic drug, prevents bone loss in estrogen-deficient mice.
Topics: Animals; Animals, Newborn; Biomechanical Phenomena; Bone and Bones; Bone Resorption; Cell Hypoxia; C | 2019 |
Deferoxamine inhibits iron-uptake stimulated osteoclast differentiation by suppressing electron transport chain and MAPKs signaling.
Topics: Animals; Bone Resorption; Cation Transport Proteins; Cell Differentiation; Cells, Cultured; Deferoxa | 2019 |
The regulation of iron metabolism by hepcidin contributes to unloading-induced bone loss.
Topics: Absorption, Physiological; Animals; Bone and Bones; Bone Resorption; Deferoxamine; Down-Regulation; | 2017 |
Desferrioxamine reduces ultrahigh-molecular-weight polyethylene-induced osteolysis by restraining inflammatory osteoclastogenesis via heme oxygenase-1.
Topics: Actins; Animals; Bone Resorption; Deferoxamine; Gene Expression Regulation; Heme Oxygenase-1; Inflam | 2016 |
Chelation therapy and bone metabolism markers in thalassemia major.
Topics: Adult; Alkaline Phosphatase; beta-Thalassemia; Bone and Bones; Bone Resorption; Case-Control Studies | 2006 |
The role of reactive oxygen intermediates in osteoclastic bone resorption.
Topics: Acetylcysteine; Animals; Animals, Newborn; Antioxidants; Bone Resorption; Cell Survival; Cells, Cult | 1995 |
Osteoclastic superoxide generation: taking control of bone resorption using modulators of superoxide concentrations.
Topics: Animals; Bone Resorption; Culture Techniques; Deferoxamine; Free Radical Scavengers; Humans; Interfe | 1992 |
Nitroblue tetrazolium reduction and bone resorption by osteoclasts in vitro inhibited by a manganese-based superoxide dismutase mimic.
Topics: Analysis of Variance; Animals; Bone Resorption; Cell Survival; Cells, Cultured; Culture Techniques; | 1992 |
Loss of bone resulting from accumulation of aluminum in bone of patients undergoing dialysis.
Topics: Adolescent; Adult; Aged; Aluminum; Bone and Bones; Bone Diseases; Bone Resorption; Child; Child, Pre | 1986 |
Incorporation of aluminium and effect of removal in experimental osteomalacia and fibro-osteoclasia.
Topics: Aluminum; Animals; Bone Resorption; Deferoxamine; Osteomalacia; Rats | 1985 |