deferoxamine has been researched along with Bone Diseases, Developmental in 11 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
Bone Diseases, Developmental: Diseases resulting in abnormal GROWTH or abnormal MORPHOGENESIS of BONES.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metaphyseal irregularity and abnormal vertebral bodies resembling a bone dysplasia were seen in two of five children with thalassemia major who were begun on a regimen of hypertransfusion and chelation with deferoxamine before the age of 3 years." | 7.68 | Deferoxamine-induced bone dysplasia in patients with thalassemia major. ( Brill, PW; Cunningham-Rundles, S; Giardina, PJ; Winchester, P, 1991) |
| "Metaphyseal irregularity and abnormal vertebral bodies resembling a bone dysplasia were seen in two of five children with thalassemia major who were begun on a regimen of hypertransfusion and chelation with deferoxamine before the age of 3 years." | 3.68 | Deferoxamine-induced bone dysplasia in patients with thalassemia major. ( Brill, PW; Cunningham-Rundles, S; Giardina, PJ; Winchester, P, 1991) |
| "Current thalassemia major treatment includes blood transfusion and iron chelation, which is associated with growth disturbances and radiographic changes in the long bone metaphyses." | 2.78 | Deferoxamine-induced dysplasia-like skeletal abnormalities at radiography and MRI. ( Esmail, RI; Lotfy, HM; Magdy, RE; Seif El Dien, HM, 2013) |
| "Thirty-five patients with homozygous ss-thalassemia major who were undergoing regular transfusions and chelation therapy underwent coronal T1-weighted MR imaging of the femur, including the femoral head and the distal femoral epiphysis." | 1.31 | Deferoxamine-induced bone dysplasia in the distal femur and patella of pediatric patients and young adults: MR imaging appearance. ( Chan, Y; Cheng, JC; Chik, KW; Chu, WC; Li, C; Pang, L, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 4 (36.36) | 29.6817 |
| 2010's | 1 (9.09) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Seif El Dien, HM | 1 |
| Esmail, RI | 1 |
| Magdy, RE | 1 |
| Lotfy, HM | 1 |
| Miller, TT | 1 |
| Caldwell, G | 1 |
| Kaye, JJ | 1 |
| Arkin, S | 1 |
| Burke, S | 1 |
| Brill, PW | 2 |
| Naselli, A | 1 |
| Vignolo, M | 1 |
| Di Battista, E | 1 |
| Garzia, P | 1 |
| Forni, GL | 1 |
| Traverso, T | 1 |
| Aicardi, G | 1 |
| De Sanctis, V | 1 |
| Stea, S | 1 |
| Savarino, L | 1 |
| Scialpi, V | 1 |
| Traina, GC | 1 |
| Chiarelli, GM | 1 |
| Sprocati, M | 1 |
| Govoni, R | 1 |
| Pezzoli, D | 1 |
| Gamberini, R | 1 |
| Rigolin, F | 1 |
| Chan, YL | 3 |
| Li, CK | 3 |
| Pang, LM | 3 |
| Chik, KW | 4 |
| Chan, Y | 1 |
| Li, C | 1 |
| Chu, WC | 1 |
| Pang, L | 1 |
| Cheng, JC | 2 |
| Chu, CW | 1 |
| Shing, MK | 1 |
| Borenstein, ZC | 1 |
| Hyman, CB | 1 |
| Rimoin, DL | 1 |
| Chapman, CL | 1 |
| Lachman, R | 1 |
| Winchester, P | 1 |
| Giardina, PJ | 1 |
| Cunningham-Rundles, S | 1 |
| Piomelli, S | 1 |
| Danoff, SJ | 1 |
| Becker, MH | 1 |
| Lipera, MJ | 1 |
| Travis, SF | 1 |
1 trial available for deferoxamine and Bone Diseases, Developmental
| Article | Year |
|---|---|
Deferoxamine-induced dysplasia-like skeletal abnormalities at radiography and MRI.
Topics: Adolescent; Adult; beta-Thalassemia; Bone Diseases, Developmental; Chelating Agents; Child; Child, P | 2013 |
10 other studies available for deferoxamine and Bone Diseases, Developmental
| Article | Year |
|---|---|
MR imaging of deferoxamine-induced bone dysplasia in an 8-year-old female with thalassemia major.
Topics: beta-Thalassemia; Bone Diseases, Developmental; Child; Deferoxamine; Female; Femur; Growth Plate; Hu | 1993 |
Long-term follow-up of skeletal dysplasia in thalassaemia major.
Topics: Adolescent; Adult; beta-Thalassemia; Blood Transfusion; Body Height; Bone Diseases, Developmental; D | 1998 |
Growth hormone secretion and bone histomorphometric study in thalassaemic patients with acquired skeletal dysplasia secondary to desferrioxamine.
Topics: Adolescent; beta-Thalassemia; Biopsy; Bone and Bones; Bone Diseases, Developmental; Cartilage; Child | 1998 |
Desferrioxamine-induced long bone changes in thalassaemic patients - radiographic features, prevalence and relations with growth.
Topics: Adolescent; Adult; beta-Thalassemia; Blood Transfusion; Body Height; Bone and Bones; Bone Diseases, | 2000 |
Deferoxamine-induced bone dysplasia in the distal femur and patella of pediatric patients and young adults: MR imaging appearance.
Topics: Adolescent; Adult; beta-Thalassemia; Bone Diseases, Developmental; Chelating Agents; Child; Deferoxa | 2000 |
Deferoxamine-induced dysplasia of the knee: sonographic features and diagnostic performance compared with magnetic resonance imaging.
Topics: Adolescent; beta-Thalassemia; Blood Transfusion; Bone Diseases, Developmental; Chelating Agents; Chi | 2001 |
Patterns of bone diseases in transfusion-dependent homozygous thalassaemia major: predominance of osteoporosis and desferrioxamine-induced bone dysplasia.
Topics: Adolescent; Adult; beta-Thalassemia; Blood Transfusion; Bone and Bones; Bone Diseases, Developmental | 2002 |
Case report 744. Deferoxamine-induced skeletal dysplasia.
Topics: beta-Thalassemia; Blood Transfusion; Bone Diseases, Developmental; Child; Deferoxamine; Female; Huma | 1992 |
Deferoxamine-induced bone dysplasia in patients with thalassemia major.
Topics: Adolescent; Age Factors; Blood Transfusion; Bone Diseases, Developmental; Child; Deferoxamine; Femal | 1991 |
Prevention of bone malformations and cardiomegaly in Cooley's anemia by early hypertransfusion regimen.
Topics: Blood Transfusion; Bone Diseases, Developmental; Cardiomyopathies; Child; Child, Preschool; Deferoxa | 1969 |