deferoxamine has been researched along with Bladder Cancer in 8 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Therefore, three bladder cancer cell lines with distinct genetic and molecular backgrounds (T24, 5637 and HT1376) were submitted to hypoxia." | 1.43 | Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension. ( Amaro, T; Azevedo, R; Cotton, S; Fernandes, E; Ferreira, JA; Gaiteiro, C; Lima, L; Neves, M; Oliveira, MJ; Palmeira, C; Parreira, B; Peixoto, A; Rangel, M; Reis, CA; Santos, LL; Silva, AM; Soares, J; Tavares, A; Teixeira, F, 2016) |
| "Accordingly, three bladder cancer cell lines (T24, 5637, and HT1376) representative of two distinct carcinogenesis pathways to invasive cancer (FGFR3/CCND1 and E2F3/RB1) were used." | 1.43 | Reference Genes for Addressing Gene Expression of Bladder Cancer Cell Models under Hypoxia: A Step Towards Transcriptomic Studies. ( Ferreira, JA; Gaiteiro, C; Lima, L; Neves, M; Peixoto, A; Santos, LL; Soares, J, 2016) |
| " Of these, the Zn(II), Cu(II), and Fe(II) complexes were without toxic effect, whereas the Ca(II), Mn(II), and Mg(II) complexes remained cytotoxic." | 1.30 | Tumor cell cytotoxicity of a novel metal chelator. ( Brechbiel, MW; Park, G; Planalp, RP; Torti, FM; Torti, SV; Whitman, SP, 1998) |
| "We show here that bladder cancer cell proliferation in vitro is dependent on Tf-Fe." | 1.29 | Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation. ( Domenico, J; Gelfand, EW; Schleicher, RB; Seligman, PA; Siriwardana, G, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (37.50) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beckford Vera, DR | 1 |
| Smith, CC | 1 |
| Bixby, LM | 1 |
| Glatt, DM | 1 |
| Dunn, SS | 1 |
| Saito, R | 1 |
| Kim, WY | 1 |
| Serody, JS | 1 |
| Vincent, BG | 1 |
| Parrott, MC | 1 |
| Inoue, K | 2 |
| Fukuhara, H | 1 |
| Kurabayashi, A | 2 |
| Furihata, M | 2 |
| Tsuda, M | 1 |
| Nagakawa, K | 1 |
| Fujita, H | 2 |
| Utsumi, K | 2 |
| Shuin, T | 2 |
| Peixoto, A | 2 |
| Fernandes, E | 1 |
| Gaiteiro, C | 2 |
| Lima, L | 2 |
| Azevedo, R | 1 |
| Soares, J | 2 |
| Cotton, S | 1 |
| Parreira, B | 1 |
| Neves, M | 2 |
| Amaro, T | 1 |
| Tavares, A | 1 |
| Teixeira, F | 1 |
| Palmeira, C | 1 |
| Rangel, M | 1 |
| Silva, AM | 1 |
| Reis, CA | 1 |
| Santos, LL | 2 |
| Oliveira, MJ | 1 |
| Ferreira, JA | 2 |
| Karashima, T | 1 |
| Kamada, M | 1 |
| Sasaki, J | 1 |
| Iinuma, S | 1 |
| Farshi, SS | 1 |
| Ortel, B | 1 |
| Hasan, T | 1 |
| Seligman, PA | 1 |
| Schleicher, RB | 1 |
| Siriwardana, G | 1 |
| Domenico, J | 1 |
| Gelfand, EW | 1 |
| Torti, SV | 1 |
| Torti, FM | 1 |
| Whitman, SP | 1 |
| Brechbiel, MW | 1 |
| Park, G | 1 |
| Planalp, RP | 1 |
8 other studies available for deferoxamine and Bladder Cancer
| Article | Year |
|---|---|
Immuno-PET imaging of tumor-infiltrating lymphocytes using zirconium-89 radiolabeled anti-CD3 antibody in immune-competent mice bearing syngeneic tumors.
Topics: Animals; Antibodies; Butylhydroxybutylnitrosamine; CD3 Complex; CD4-Positive T-Lymphocytes; CD8-Posi | 2018 |
Photodynamic therapy involves an antiangiogenic mechanism and is enhanced by ferrochelatase inhibitor in urothelial carcinoma.
Topics: Aminolevulinic Acid; Angiogenesis Inhibitors; Animals; Apoptosis; Carcinoma, Transitional Cell; Cell | 2013 |
Hypoxia enhances the malignant nature of bladder cancer cells and concomitantly antagonizes protein O-glycosylation extension.
Topics: Adult; Aged; Aged, 80 and over; Antigens, CD; Antigens, Neoplasm; Carbonic Anhydrase IX; Cell Hypoxi | 2016 |
Reference Genes for Addressing Gene Expression of Bladder Cancer Cell Models under Hypoxia: A Step Towards Transcriptomic Studies.
Topics: Actins; beta 2-Microglobulin; Cell Line, Tumor; Deferoxamine; Electron Transport Complex II; Gene Ex | 2016 |
Regulation of 5-aminolevulinic acid-mediated protoporphyrin IX accumulation in human urothelial carcinomas.
Topics: Aminolevulinic Acid; beta-Alanine; Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone; Carcinoma, Tr | 2009 |
A mechanistic study of cellular photodestruction with 5-aminolaevulinic acid-induced porphyrin.
Topics: Aminolevulinic Acid; Animals; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Cell Division; | 1994 |
Effects of agents that inhibit cellular iron incorporation on bladder cancer cell proliferation.
Topics: Cell Transformation, Neoplastic; Deferoxamine; Gallium; Humans; Indium; Iron; Protein Binding; Trans | 1993 |
Tumor cell cytotoxicity of a novel metal chelator.
Topics: Alkylation; Antineoplastic Agents; Cations, Divalent; Cell Division; Cells, Cultured; Chelating Agen | 1998 |