deferoxamine has been researched along with Becker Muscular Dystrophy in 2 studies
Deferoxamine: Natural product isolated from Streptomyces pilosus. It forms iron complexes and is used as a chelating agent, particularly in the mesylate form.
desferrioxamine B : An acyclic desferrioxamine that is butanedioic acid in which one of the carboxy groups undergoes formal condensation with the primary amino group of N-(5-aminopentyl)-N-hydroxyacetamide and the second carboxy group undergoes formal condensation with the hydroxyamino group of N(1)-(5-aminopentyl)-N(1)-hydroxy-N(4)-[5-(hydroxyamino)pentyl]butanediamide. It is a siderophore native to Streptomyces pilosus biosynthesised by the DesABCD enzyme cluster as a high affinity Fe(III) chelator.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Based on evidence that excess iron may increase oxidative stress and contribute to the inflammatory response, we investigated whether deferoxamine (DFX), a potent iron chelating agent, reduces oxidative stress and inflammation in the diaphragm (DIA) muscle of mdx mice (an experimental model of DMD)." | 3.81 | Reduction of Oxidative Damage and Inflammatory Response in the Diaphragm Muscle of mdx Mice Using Iron Chelator Deferoxamine. ( de Almeida Hermes, T; de Burgos, RR; de Faria, FM; Macedo, AB; Minatel, E; Moraes, LH, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moraes, LH | 2 |
| Bollineli, RC | 1 |
| Mizobuti, DS | 1 |
| Silveira, Ldos R | 1 |
| Marques, MJ | 1 |
| Minatel, E | 2 |
| de Burgos, RR | 1 |
| Macedo, AB | 1 |
| de Almeida Hermes, T | 1 |
| de Faria, FM | 1 |
2 other studies available for deferoxamine and Becker Muscular Dystrophy
| Article | Year |
|---|---|
Effect of N-acetylcysteine plus deferoxamine on oxidative stress and inflammation in dystrophic muscle cells.
Topics: Acetylcysteine; Aldehydes; Animals; Cells, Cultured; Deferoxamine; Hydrogen Peroxide; Inflammation; | 2015 |
Reduction of Oxidative Damage and Inflammatory Response in the Diaphragm Muscle of mdx Mice Using Iron Chelator Deferoxamine.
Topics: Animals; Blotting, Western; Body Weight; Deferoxamine; Diaphragm; Female; Inflammation; Injections, | 2015 |